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Achieving mono-selective palladium(II)-catalysed C–H activation of arenes with protein ligands

Molecular organometallic catalysts typically struggle to activate only one of two identical C–H bonds in arenes for mono-selective C–H activation. Now mono-selectivity has been achieved for Pd(II)-catalysed ortho- or meta-C–H activations using commercial proteins or designed peptides as ligands.

Hua-Jin Xu
Zhoulong Fan
Jin-Quan Yu
Research08 Sept 2025
Nature Catalysis

Volume: 8, P: 948-956
Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice: involvement of adjusting neurotransmitters and their metabolite changes in the brain

Bin-bin Wei
Ming-yan Liu
Min-jie Wei
Research11 Jan 2018
Acta Pharmacologica Sinica

Volume: 39, P: 616-625
Chemically gated artificial nanochannels for programmable subcellular signal modulated transport regulation

Biomimetic artificial nanochannels have potential applications in signal regulation and subcellular biosensing. Here authors present artificial nanochannels based on DNA-functionalized glass nanopipettes, which when targeted to mitochondria can be used to evaluate and manipulate the interaction network between mitochondria and other organelles.

Man-Sha Wu
Xi-Chen Du
Ruo-Can Qian
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Palladium-catalyzed allene synthesis enabled by β-hydrogen elimination from sp²-carbon

β-Hydrogen elimination is a fundamental reaction in palladium catalysis, however, the eliminated β-hydrogen is usually attached to a sp³-carbon. Here, the authors report a palladium-catalyzed cross-coupling reaction involving a β-vinylic hydrogen elimination from an allylic palladium intermediate.

Ge Zhang
Yi-Kang Song
Guo-Qiang Lin
ResearchOpen Access01 Feb 2021
Nature Communications

Volume: 12, P: 1-10
Density alteration in non-physiological cells

Ming Wang
Hai-Cheng Li
Jian-Ge Wei
ResearchOpen Access17 Oct 2011
Nature Precedings

P: 1
Bipartite reweight-annealing algorithm of quantum Monte Carlo to extract large-scale data of entanglement entropy and its derivative

Entanglement entropy is a crucial quantity in several research fields, yet its calculation in higher-dimensional systems remains challenging. Here the authors develop a quantum Monte Carlo-based algorithm to efficiently extract large-scale entanglement entropy data and apply it to quantum critical systems.

Zhe Wang
Zhiyan Wang
Zheng Yan
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-8
Mechanical force-induced interlayer sliding in interfacial ferroelectrics

Manipulation of controllable polarization evolutions is a big challenge. The authors fabricate the irregular moirés, identifying three distinct types of moiré domains with different patterns, modulating them by external mechanical force disturbing.

Zhao Guan
Lu-qi Wei
Ni Zhong
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-7
Robotic versus laparoscopic distal gastrectomy for resectable gastric cancer: a randomized phase 2 trial

Robotic surgery has been demonstrated to improve short-term outcomes for patients with gastric cancer who received a gastrectomy, but the long-term effects are less clear. Here, the authors report the survival outcomes of their phase 2 randomized controlled trial comparing robotic to laparoscopic distal gastrectomy in patients with resectable gastric cancer.

Jun Lu
Bin-bin Xu
Chang-Ming Huang
ResearchOpen Access31 May 2024
Nature Communications

Volume: 15, P: 1-10
Evidence for a brief appearance of gamma-ray periodicity after a compact star merger

A coherent 909-Hz quasi-periodic oscillation was potentially detected in GRB 230307A, the second brightest gamma-ray burst to date, indicating that a millisecond magnetar formed after the merger powered the burst.

Run-Chao Chen
Bin-Bin Zhang
Bing Zhang
Research19 Sept 2025
Nature Astronomy

Volume: 9, P: 1701-1713
Significant survival benefit of adjuvant chemotherapy after concurrent chemoradiotherapy in locally advanced high-risk nasopharyngeal carcinoma

Zhong-Guo Liang
Xiao-Qian Chen
Xiao-Dong Zhu
ResearchOpen Access02 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
Edge polarization topology integrated with sliding ferroelectricity in Moiré system

The authors reveal a complex polarization network in twisted bilayer h-BN, featuring edge polarization topology and sliding ferroelectricity, driven by the interplay of ferroelectric and piezoelectric effects.

Wen-Cheng Fan
Zhao Guan
Chun-Gang Duan
ResearchOpen Access15 Apr 2025
Nature Communications

Volume: 16, P: 1-8
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf^V600E inhibitors

Gui-min Wang
Xiang Wang
Jian Ding
Research17 Apr 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1059-1068
Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway

Yuan-chao Ye
Hong-ju Wang
Takashi Ikejima
Research30 Jul 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1055-1061
Locally collective hydrogen bonding isolates lead octahedra for white emission improvement

Low dimensional lead halide perovskites possess intriguing optical properties that are still under debate. Here Cui et al. use hydrogen bonds containing spacers to synthesize highly luminescent perovskites with fully isolated lead-bromide octahedras and shed light on the origin of the emission.

Bin-Bin Cui
Ying Han
Qi Chen
ResearchOpen Access15 Nov 2019
Nature Communications

Volume: 10, P: 1-8
Sampling reduced density matrix to extract fine levels of entanglement spectrum and restore entanglement Hamiltonian

The reduced density matrix enables extraction of entanglement-related quantities but computing it for large quantum systems is challenging. Mao et al. combine quantum Monte Carlo with exact diagonalization to efficiently extract the reduced density matrix and entanglement spectrum in large 1D and 2D systems.

Bin-Bin Mao
Yi-Ming Ding
Zheng Yan
ResearchOpen Access24 Mar 2025
Nature Communications

Volume: 16, P: 1-8
Unveiling key genes for intervertebral disc degeneration prediction and potential drug discovery

Tian-jie Li
Yuan-sheng Wang
Jian-wei Liu
ResearchOpen Access11 Dec 2025
Scientific Reports

Volume: 16, P: 1-10
Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats

Long-shan Zhao
Ran Yin
Kai-shun Bi
Research15 Oct 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1348-1352
Realization of topological Mott insulator in a twisted bilayer graphene lattice model

Magic-angle twisted bilayer graphene exhibits a quantum anomalous Hall effect at 3/4 filling; however, its mechanism is debated. Here, the authors show that such a phase can be realized in a lattice model of twisted bilayer graphene in the strong coupling limit, and interpret the results in terms of a topological Mott insulator phase.

Bin-Bin Chen
Yuan Da Liao
Zi Yang Meng
ResearchOpen Access16 Sept 2021
Nature Communications

Volume: 12, P: 1-7
Kosterlitz-Thouless melting of magnetic order in the triangular quantum Ising material TmMgGaO₄

TmMgGaO₄ is one of a number of recently-synthesized quantum magnets that are proposed to realize important theoretical models. Here the authors demonstrate the agreement between detailed experimental measurements and state-of-the-art predictions based on the 2D transverse-field triangular lattice Ising model.

Han Li
Yuan Da Liao
Wei Li
ResearchOpen Access28 Feb 2020
Nature Communications

Volume: 11, P: 1-8
Regulation of T cell function by microRNA-720

Yu Wang
Zheng Zhang
You-Wen He
ResearchOpen Access22 Jul 2015
Scientific Reports

Volume: 5, P: 1-10
Mild decrease in TBX20 promoter activity is a potentially protective factor against congenital heart defects in the Han Chinese population

Li-Wei Yu
Feng Wang
Hong-Yan Wang
ResearchOpen Access01 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne

Li-Li Hong
Hao-Bing Yu
Hou-Wen Lin
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

Lin Wang
Jia-Bao Cao
Jun Wang
ResearchOpen Access10 Nov 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
Dysivillosins A–D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa

Wei-Hua Jiao
Bao-Hui Cheng
Hou-Wen Lin
ResearchOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Increased BBB permeability contributes to EGCG-caused cognitive function improvement in natural aging rats: pharmacokinetic and distribution analyses

Bin-bin Wei
Ming-yan Liu
Min-jie Wei
Research15 May 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1490-1500
Design and characterization of high-performance energetic hydrogels with enhanced mechanical and explosive properties

Xi-chen Liu
Yi-min Luo
Bin-bin Wang
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway

Sha Li
Hong Yang
Jin-hua Wang
Amendments and Corrections25 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2450-2451
Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway

Wen-ya Ma
Rui-jie Song
Ben-zhi Cai
Research24 Aug 2020
Acta Pharmacologica Sinica

Volume: 42, P: 921-931
Spin-triplet pairing induced by near-neighbor attraction in the extended Hubbard model for cuprate chain

Recent experiments have identified the underlying model of one-dimensional cuprate chains as the extended Hubbard model with attractive near-neighbor interactions. Here, the authors use many-body calculations to create an exact ground-state phase diagram of this model, demonstrating a rich diversity of exotic quantum states, and providing valuable guidance for realizing unconventional superconductivity in the system.

Dai-Wei Qu
Bin-Bin Chen
Wei Li
ResearchOpen Access21 Oct 2022
Communications Physics

Volume: 5, P: 1-8
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis

Xiang-jin Zheng
Wen-lin Chen
Jin-hua Wang
Amendments and Corrections13 May 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2226-2227
Potentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis

Bin-bin Li
Dong-liang Li
Liang Zhu
ResearchOpen Access28 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis

Xiang-jin Zheng
Wen-lin Chen
Jin-hua Wang
Amendments and Corrections16 Aug 2022
Acta Pharmacologica Sinica

Volume: 43, P: 3011-3012
Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis

Xiang-jin Zheng
Wen-lin Chen
Jin-hua Wang
Research17 May 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2977-2992
Superatomic icosahedral-C_nB_12-n (n = 0, 1, 2) Stuffed mononuclear and binuclear borafullerene and borospherene nanoclusters with spherical aromaticity

Min Zhang
Wei-Ping Jia
Si-Dian Li
ResearchOpen Access17 Nov 2022
Scientific Reports

Volume: 12, P: 1-9
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway

Ya-xian Wu
Ying-ying Wang
Qing-feng Pang
Research20 Aug 2021
Acta Pharmacologica Sinica

Volume: 42, P: 2069-2081
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway

Sha Li
Hong Yang
Jin-Hua Wang
Research30 Mar 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2709-2722
Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans

Wei-min Kong
Bin-bin Sun
Xiao-dong Liu
Research22 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 852-865
Root and nitrate-N distribution and optimization of N input in winter wheat

Bin-Bin Guo
Bei-Cheng Liu
Tian-Cai Guo
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143

Hai-Jie Yang
Fei Ju
Mian Wang
ResearchOpen Access30 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Unusual shrinkage and reshaping of Earth’s magnetosphere under a strong northward interplanetary magnetic field

Open magnetic flux in the polar cap almost completely disappeared and the Earth’s magnetotail was compressed into a calabash shape during the 9th April 2015 coronal mass ejection, according to magnetohydrodynamic simulations and observations from DMSP and THEMIS.

Xiang-Yu Wang
Qing-He Zhang
Yong Wang
ResearchOpen Access13 Feb 2023
Communications Earth & Environment

Volume: 4, P: 1-8
Chlorogenic acid analogues from Gynura nepalensis protect H9c2 cardiomyoblasts against H₂O₂-induced apoptosis

Bang-wei Yu
Jin-long Li
He-yao Wang
Research05 Sept 2016
Acta Pharmacologica Sinica

Volume: 37, P: 1413-1422

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