Nature Search

Precision estimates of longitudinal brain aging capture unexpected individual differences in one year

Repeated rapid structural MRI scans substantially improve the precision of individual differences in brain change. This allowed for individualized insight into subtle differences in the detected rates of brain aging and neurodegeneration to be detected.

Maxwell L. Elliott
Jingnan Du
Randy L. Buckner
ResearchOpen Access05 Feb 2026
Nature Communications

P: 1-16
Author Correction: Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Neguine Rezaii
Bonnie Wong
Kathy Newell
Amendments and CorrectionsOpen Access31 Dec 2025
npj Dementia

Volume: 1, P: 1
Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Neguine Rezaii
Bonnie Wong
Kathy Newell
ResearchOpen Access03 Nov 2025
npj Dementia

Volume: 1, P: 1-11
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

Cyril Pottier
Fahri Küçükali
Rosa Rademakers
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Correction: Corrigendum: Amygdala volume and social network size in humans

Kevin C Bickart
Christopher I Wright
Lisa Feldman Barrett
Amendments and Corrections26 Aug 2011
Nature Neuroscience

Volume: 14, P: 1217
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Evidence for a large-scale brain system supporting allostasis and interoception in humans

Kleckner et al. use monkey and human data to identify an intrinsic brain system that supports interoception (that is, sensations from within the body) and allostasis (that is, the process by which the brain maintains energy regulation in the body).

Ian R. Kleckner
Jiahe Zhang
Lisa Feldman Barrett
Research24 Apr 2017
Nature Human Behaviour

Volume: 1, P: 1-14
[¹¹C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

The link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression.

Tharick A. Pascoal
Mira Chamoun
Pedro Rosa-Neto
ResearchOpen Access19 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Rowan Saloner
Adam M. Staffaroni
Kaitlin B. Casaletto
Amendments and CorrectionsOpen Access07 Jul 2025
Nature Aging

Volume: 5, P: 1372
Amygdala volume and social network size in humans

The volume of the human amygdala correlates with the size and complexity of individual social networks, reports this study. This correlation still exists after correcting for intracranial volume, and seems to be specific to the amygdala and not other subcortical structures.

Kevin C Bickart
Christopher I Wright
Lisa Feldman Barrett
Research26 Dec 2010
Nature Neuroscience

Volume: 14, P: 163-164
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311

A M Burger
T C Jenkins
M C Bibby
ResearchOpen Access27 Aug 1999
British Journal of Cancer

Volume: 81, P: 367-375
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Saloner et al. used large-scale cerebrospinal fluid proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression.

Rowan Saloner
Adam M. Staffaroni
Kaitlin B. Casaletto
ResearchOpen Access16 May 2025
Nature Aging

Volume: 5, P: 1143-1158
Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes in tauopathy patient-derived neurons.

M. Catarina Silva
Ghata A. Nandi
Stephen J. Haggarty
ResearchOpen Access26 Jun 2020
Nature Communications

Volume: 11, P: 1-18
Author Correction: [¹¹C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Tharick A. Pascoal
Mira Chamoun
Pedro Rosa-Neto
Amendments and CorrectionsOpen Access03 Oct 2022
Nature Communications

Volume: 13, P: 1
Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

Plasma pTau181 concentrations are elevated specifically in patients diagnosed with Alzheimer’s disease compared to those diagnosed with frontotemporal lobar degeneration or elderly controls, supporting its further development as a blood-based biomarker for AD.

Elisabeth H. Thijssen
Renaud La Joie
Bradford C. Dickerson
Research02 Mar 2020
Nature Medicine

Volume: 26, P: 387-397
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

Chialin Cheng
Surya A. Reis
Stephen J. Haggarty
ResearchOpen Access23 Aug 2021
Scientific Reports

Volume: 11, P: 1-21
The Episodic Memory System: Neurocircuitry and Disorders

Bradford C Dickerson
Howard Eichenbaum
Reviews23 Sept 2009
Neuropsychopharmacology

Volume: 35, P: 86-104
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Patterns of attendances to the hospital emergency eye care service: a multicentre study in England

Ian De Silva
Mervyn G. Thomas
Seema Verma
Research30 Nov 2021
Eye

Volume: 36, P: 2304-2311
Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia

Christine E Marx
Richard S E Keefe
Lawrence J Shampine
Research01 Apr 2009
Neuropsychopharmacology

Volume: 34, P: 1885-1903
Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus

Analysis of functional MRI data from the Human Connectome Project and Brain Genomics Superstruct Project reveals common functional gradients among the human isocortex, cerebellum, and hippocampus.

Yuta Katsumi
Jiahe Zhang
Lisa Feldman Barrett
ResearchOpen Access12 Apr 2023
Communications Biology

Volume: 6, P: 1-13
Intrinsic Functional Connectivity is Organized as Three Interdependent Gradients

Jiahe Zhang
Olamide Abiose
Lisa Feldman Barrett
ResearchOpen Access04 Nov 2019
Scientific Reports

Volume: 9, P: 1-14
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

Delnaz Roshandel
Eric J. Sanders
Helen Cockerill
ResearchOpen Access28 Sept 2023
npj Genomic Medicine

Volume: 8, P: 1-11

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