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PROTAC development has surged in popularity, however our ability to characterize PROTAC specificity in living cells has lagged behind. Here, the authors develop ProtacID, a flexible proximity-dependent biotinylation (BioID)-based approach to identify PROTAC-protein interactions in living cells.

Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action studies identified LolCDE as its molecular target.

In June 2022, the IXPE satellite observed a shock passing through the jet of active galaxy Markarian 421. The rotation of the X-ray-polarized radiation over a 5-day period revealed that the jet contains a helical magnetic field.

The accretion geometry of X-ray binary Cygnus X-3 is determined here from IXPE observations. X-ray polarization reveals a narrow funnel with reflecting walls, which focuses emission, making Cyg X-3 appear as an ultraluminous X-ray source.

X-ray polarimetry observations with the Imaging X-ray Polarimetry Explorer constrain the accretion geometry in an X-ray pulsar and provide evidence for a misalignment of the spin, magnetic and orbital axes in Her X-1.

Fluid shear stress plays a role in medulloblastoma metastasis through a PIEZO2-actomyosin-GLUT1 signalling cascade.

X-ray polarization measurements of the Crab nebula and pulsar by the IXPE satellite reveal a global toroidal magnetic field with large variations in local polarization, suggesting a more complex turbulence distribution than anticipated.

Engineering strain in semiconductor structures provides additional control over the optical and electronic properties, which is promising for device applications. Fluegel et al. show that electronic Raman scattering provides a route to sensitively measure the degree of strain in thin semiconductor layers.

Polarization measurements are reported for the blazar Mk501, revealing a degree of X-ray polarization that is more than twice the optical value and supporting the shock-accelerated energy-stratified electron population scenario.

Polarization can exceed 60% at the leading edge of the inner part of the Vela pulsar wind nebula; in contrast with the case of the supernova remnant, the electrons in the pulsar wind nebula are accelerated with little or no turbulence in a highly uniform magnetic field.

Oblique line scan microscopy achieves nanoscale spatial and sub-millisecond temporal resolution across a large field of view, enabling improved and robust single-molecule biophysical measurements and single-molecule tracking in both cells and solution.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A sensitive Breakthrough Listen search for technosignatures towards Proxima Centauri has resulted in a viable narrowband signal. The observational approach, using the Parkes Murriyang telescope, is described here, while the signal of interest is analysed in a companion paper by Sheikh et al.

Lanthanide-doped upconverting nanoparticles exhibiting a 33,000 times increase in brightness and a 100 times increase in efficiency over bare upconverting nanoparticles are demonstrated. The findings are relevant in fields from solar energy to biophotonics.

A study reports the measurement of the polarization degree and angle of X-rays from Sagittarius A^* reflected off a nearby cloud, indicating an X-ray flare about 200 years ago.

Quantum teleportation has been previously demonstrated between objects of the same nature, such as light pulses or material particles. But this paper demonstrates teleportation between objects of a different nature: a quantum state encoded in a light pulse is teleported onto an atomic ensemble containing 10¹² caesium atoms.

In this work the authors use coherent anti-Stokes Raman scattering to study collisional vibrational excitation in highly rotationally excited CO2 molecules prepared in an optical centrifuge.

Integrins are promising targets in the treatment of conditions that range from cancer to acute coronary syndromes. However, the partial agonism exhibited by RGD ligand–based drugs can result in life-threatening complications. A new study provides the structural basis for pure antagonism by a high-affinity integrin ligand and suggests a path to the design of safer integrin inhibitors.

Nuclear pore complexes (NPCs) serve as gateways between the nucleus and cytoplasm and allow only the transport of selected macromolecules across the nuclear envelope. NPCs are comprised of a scaffold that anchors proteins called FG-nucleoporins, which contain disordered regions that line the inner surface of the pore and extend into the lumen. This study reports the design of an artificial membrane that functions as a selective filter in allowing efficient passage of transport factors and transport factor carrying cargo that specifically bind to FG-nucleoporins.

The mechanism by which proteins become polarized to a specific cortical site in budding yeast cells has been a topic of recent debate. Slaughter et al.show that differing diffusion rates of Cdc42 within plasma membrane environments sustain the polarized state.

Adiabatic processes are useful in quantum control, but they are slow. A way around this is to exploit shortcuts to adiabaticity, which can speed things up — for instance, by boosting stimulated Raman adiabatic passage.

Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib, and report heterogeneous erlotinib delivery to intracranial tumors to be inadequate to inhibit EGFR signaling.

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Increased visceral adipose tissue has been associated with metabolic dysfunction but the origin of the progenitors that give rise to this tissue, and whether they are the same as the progenitors contributing to the protective subcutaneous adipose tissue, was unclear. Hastie and colleagues have found that Wt1-positive mesothelial cells contribute to visceral adipocytes.

Resistance to turbulence is an ongoing challenge for point-to-point freespace communications. Here the authors present a protocol for encoding a large amount of information in vector beams that are transmittable through a moderately strong turbulent channel without adaptive beam compensation.

Theoretically predicted in 1979, hyper-Raman optical activity is now experimentally observed through chirality conferral from the electromagnetic field of chiral plasmonic gold nanohelices to crystal violet molecules that are achiral, sparking new science at the organic–inorganic interface.

Using a neural network trained on bacterial growth inhibition data, in silico prediction of molecules with activity against Acinetobacter baumannii led to the identification of the narrow-spectrum abaucin, which perturbs lipoprotein trafficking.

Odour motion contains valuable directional information that is absent from the airflow alone, and Drosophila use this directional information to shape their navigational decisions.

It is generally believed that rapid dissipation means that spatially precise heating is not feasible via thermoplasmonic means. Here, the authors induce highly localized heating around plasmonic nanostructures by pulsed laser irradiation, which effects chemical modification of surface bound molecules.

A stylized model of the climate–social system could help to understand policy and emissions futures.

Polarization-second harmonic microscopy was utilized to investigate whether collagen ultrastructure in thyroid due to four carcinoma types and Graves’ disease could be differentiated in human histopathology samples. Three parameters were extracted, revealing that the degree of linear polarization and χ⁽²⁾_zzz/χ⁽²⁾_zxx were effective in differentiating some diseases, while the parameter χ⁽²⁾_xyz/χ⁽²⁾_zxx was less effective.

The speed and efficiency of transportation and energy systems, including airplanes, ships, and wind turbines can be limited by skin-friction drag. The authors describe a pathway to drag reduction by controlling the large-scale turbulent eddies occurring away from the surface for improved function.

The influence of contaminants is one of the factors hindering self-sustained thermonuclear burn in inertial confinement fusion. Here, the authors present evidence, through simulations and experiments, that contaminants do not fully reach thermal equilibrium, and thus their amount is usually underestimated.

Semiconducting metal oxide gas sensors with a linear response, broad dynamic range and high baseline stability can be created with the help of a dielectric excitation technique.

Researchers identified 7 biological group of diffuse large B-cell lymphoma, one with poor prognosis. They developed a gene expression classifier to detect these groups, potentially improving prognosis and future treatments for the high-risk patients.

The ionosphere can give rise to irregularities that can interfere with radio communication, navigation and satellite systems. Here the authors present unique observations from the Arecibo Radio Observatory in Puerto Rico to reveal the existence of plasma irregularities occur in the mid-latitude F-region.