Nature Search

Nature of the Variation in Flower Colour in Vicia

R. C. PECKET
Research25 Mar 1967
Nature

Volume: 213, P: 1240-1241
Lithium deficiency and the onset of Alzheimer’s disease

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Liviu Aron
Zhen Kai Ngian
Bruce A. Yankner
ResearchOpen Access06 Aug 2025
Nature

Volume: 645, P: 712-721
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

Abbie S. Ireland
Daniel A. Xie
Trudy G. Oliver
ResearchOpen Access17 Sept 2025
Nature

P: 1-11
Mr. J. T. Davey and Mr. H. J. Morris

T. H. C. TAYLOR
Comments & Opinion10 Oct 1959
Nature

Volume: 184, P: 1104-1105
Nature of the Renal Lesions induced by Intravenous Injection of Carrageenan

J. C. MORARD
A. FRAY
L. ROBERT
Research25 Apr 1964
Nature

Volume: 202, P: 401-402
Naturally occurring antibodies devoid of light chains

C. Hamers-Casterman
T. Atarhouch
R. Hammers
Research03 Jun 1993
Nature

Volume: 363, P: 446-448
A knock-in mouse model for GABRG2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

Dingding Shen
Jiali Wan
Qi Zhang
ResearchOpen Access06 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-17
Reduced Atlantic reef growth past 2 °C warming amplifies sea-level impacts

An analysis of coral reefs in the tropical western Atlantic suggests that nearly all will be eroding by 2100 if global warming exceeds 2 °C, which will worsen the effects of sea-level rise.

Chris T. Perry
Didier M. de Bakker
William F. Precht
ResearchOpen Access17 Sept 2025
Nature

P: 1-8
citrOgen: a synthesis-free polysaccharide and protein antigen-presentation to antibody-induction platform

Bacterial antigens, such as lipopolysaccharides, are complex structures which remain difficult to synthesise or purify for antibody generation. Here, authors present a platform technology using Citrobacter rodentium - an enteric mouse pathogen - to both produce and present complex antigens for antibody generation.

Joshua L. C. Wong
Julia Sanchez-Garrido
Gad Frankel
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-18
The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities

Type 2 diabetes predisposes individuals to multiple comorbidities, but causal mechanisms are unclear. Here, the authors use Mendelian randomisation to show that distinct genetic pathways underlie diabetes-related risks, with ancestry-specific differences.

Ana Luiza Arruda
Ozvan Bocher
Eleftheria Zeggini
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-14
ANTXR1 blockade enhances cardiac function in preclinical models of heart failure

Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.

Nicola Boccella
GuoJun Yu
Brad St. Croix
ResearchOpen Access02 Oct 2025
Nature Cardiovascular Research

P: 1-18
Search strategy analysis of Tg4-42 Alzheimer Mice in the Morris Water Maze reveals early spatial navigation deficits

Nadine Curdt
Franziska W. Schmitt
Yvonne Bouter
ResearchOpen Access31 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice

Zhang et al. identify GLP-1 receptor agonists mitigating Alzheimer’s disease-related cognitive decline and amyloid pathology in a transgenic mouse model via promoting phagocytosis and through activation of the CaMKK2–AMPK signaling pathway.

Yun Zhang
Huaqiu Chen
Weihong Song
Research20 May 2025
Nature Aging

Volume: 5, P: 1097-1113
Natural and inducible T_H17 cells are regulated differently by Akt and mTOR pathways

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

Jiyeon S Kim
Tammarah Sklarz
Gary A Koretzky
Research05 May 2013
Nature Immunology

Volume: 14, P: 611-618
Higher mortality following SARS-CoV-2 infection in rural versus urban dwellers persists for two years post-infection

People living in rural areas of the United States have poorer outcomes from acute COVID-19. Here, the authors show that higher mortality rates among rural dwellers persist for up to two years after the initial infection, even after accounting for baseline risk factors.

A. Jerrod Anzalone
Michael T. Vest
Christopher G. Chute
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-18
FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

Follicle stimulating hormone (FSH) has been shown to Alzheimer’s disease like pathology in rodent models. Here the authors show using cellular and animal models that ApoE4 and FSH collectively act to trigger AD-like pathogenesis, by activating C/EBPβ/δ-secretase signalling.

Jing Xiong
Seong Su Kang
Keqiang Ye
ResearchOpen Access18 Oct 2023
Nature Communications

Volume: 14, P: 1-17
Astrocytic adenosine receptor A_2A and G_s-coupled signaling regulate memory

The authors show that astrocytes produce high levels of the adenosine receptor A2A in Alzheimer brains. Reducing the levels of astrocytic A2A boosted memory in young and aging mice and mouse models of Alzheimer disease, whereas activating a related molecular pathway impaired memory. Thus, astrocytes regulate memory and abnormal receptor activity in these cells may contribute to memory disorders.

Anna G Orr
Edward C Hsiao
Lennart Mucke
Research26 Jan 2015
Nature Neuroscience

Volume: 18, P: 423-434
Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Mitotic block and epigenetic repression underlie neurodevelopmental defects and neurobehavioral deficits in congenital heart disease

Mouse modeling shows neurodevelopmental defects associated with complex congenital heart disease can arise independent of the cardiac defects, with microcephaly and autism occurring with incomplete penetrance subject to epigenetic regulation.

George C. Gabriel
Hisato Yagi
Cecilia W. Lo
ResearchOpen Access07 Jan 2025
Nature Communications

Volume: 16, P: 1-19
A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry

Microbes drive the Earth’s biogeochemical cycles. Here, Li et al. present a framework for integrating genome-inferred microbial kinetic traits into ecosystem mechanistic models, and use it to benchmark predictions against observed greenhouse gas emissions at an Arctic wetland.

Zhen Li
William J. Riley
Eoin L. Brodie
ResearchOpen Access04 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Annual Rhythm of Wool Growth

J. W. BENNETT
J. C. D. HUTCHINSON
MANIKA WODZICKA-TOMASZEWSKA
Research19 May 1962
Nature

Volume: 194, P: 651-652
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Rate and noise in human amygdala drive increased exploration in aversive learning

Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.

Tamar Reitich-Stolero
Kristoffer C. Aberg
Rony Paz
Research27 Aug 2025
Nature

P: 1-10
Evidence for polycyclic aromatic hydrocarbons detected in sulfates at Jezero crater by the Perseverance rover

The Perseverance rover detected polycyclic aromatic hydrocarbons preserved within sulfates in the fan and floor of Jezero crater on Mars, offering new insights into past habitability and the preservation of organic matter on Mars.

Teresa Fornaro
Sunanda Sharma
Amy J. Williams
Research04 Sept 2025
Nature Astronomy

P: 1-14
Nature Study in Elementary Schools; a Manual for Teachers

L. C. M.
Books & Arts10 Feb 1898
Nature

Volume: 57, P: 340
A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease

The mechanisms that underlie cognitive resilience during aging are poorly understood. Here, the authors describe a neurodegeneration checkpoint response mediated by the transcription factor REST that protects against the onset of Alzheimer’s disease.

Liviu Aron
Chenxi Qiu
Bruce A. Yankner
ResearchOpen Access02 Nov 2023
Nature Communications

Volume: 14, P: 1-22
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Clozapine induces perineuronal net remodeling in a developmental mouse model exhibiting schizophrenia-relevant phenotypes

Susana García-Cerro
Ana Gómez-Garrido
Benedicto Crespo-Facorro
Research25 Sept 2025
Neuropsychopharmacology

P: 1-14
Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice

Gut dysbiosis contributes to Alzheimer’s disease (AD) pathogenesis, and Bacteroides strains are commonly enriched in AD gut microbiota. Here, the authors show that Bacteroides fragilis and its metabolites 12-hydroxy-heptadecatrienoic acid (12-HHTrE) and Prostaglandin E2 (PGE2) can mediate activation of microglia and induce AD pathogenesis in neuronal C/EBPβ transgenic mice.

Yiyuan Xia
Yifan Xiao
Keqiang Ye
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-20
The Electron Affinity of Atomic Oxygen

L. M. BRANSCOMB
Research26 Jul 1958
Nature

Volume: 182, P: 248-249
Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

LRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for cognitive function in mice.

Karen Perez de Arce
Adema Ribic
Thomas Biederer
ResearchOpen Access28 Jan 2023
Nature Communications

Volume: 14, P: 1-18
Nicotine rebalances NAD⁺ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

Nicotine, a metabolite of the NAD+ metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remained unknown. Here, the authors show that low-dose nicotine promotes SIRT1 deacetylation of NAMPT and enhanced NAMPT activity which boosts NAD generation and improves age related symptoms.

Liang Yang
Junfeng Shen
Xiang Li
ResearchOpen Access17 Feb 2023
Nature Communications

Volume: 14, P: 1-17
Estimation of Electron Affinities of Oxygen by Extrapolations of Ionization Potentials

D. F. C. MORRIS
H. N. SCHMEISING
Research15 Feb 1958
Nature

Volume: 181, P: 469-470
Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent T_reg–microglia crosstalk

Nasal anti-CD3 therapy shows promise for treating traumatic brain injury by reducing neuroinflammation and aiding recovery in mice. It induces interleukin-10-producing regulatory T cells that enhance microglial phagocytic activity and reduce chronic inflammation, potentially aiding brain repair.

Saef Izzy
Taha Yahya
Howard L. Weiner
ResearchOpen Access27 Feb 2025
Nature Neuroscience

Volume: 28, P: 499-516
Evidence for Asymmetry of Jupiter's Van Allen Belt

J. A. ROBERTS
M. M. KOMESAROFF
Research22 Aug 1964
Nature

Volume: 203, P: 827-830
Long-term gene therapy in the CNS: Reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin

Brad J. Geddes
Tom C. Harding
James B. Uney
Research01 Dec 1997
Nature Medicine

Volume: 3, P: 1402-1404
RSPO3 is important for trabecular bone and fracture risk in mice and humans

Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.

Karin H. Nilsson
Petra Henning
Claes Ohlsson
ResearchOpen Access13 Aug 2021
Nature Communications

Volume: 12, P: 1-18
Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment

Splicing dysfunction has been observed in Alzheimer’s disease but it remains unclear whether splicing defects have a causal role. Here the authors generate a mouse model with perturbed U1 snRNP activity, recapitulating RNA splicing defects, neuron hyperexcitability, neurodegeneration and synergy with the amyloid cascade when crossed with 5xFAD mice.

Ping-Chung Chen
Xian Han
Junmin Peng
Research12 Oct 2022
Nature Aging

Volume: 2, P: 923-940
Leucoanthocyanins from the Leaves of European Larch (Larix decidua, Mill)

H. G. C. KING
Research27 Aug 1966
Nature

Volume: 211, P: 944-945
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

Mechanisms of cognitive resilience against Tau pathology are unknown. The authors show that inactivation of the microglial cGAS–interferon axis confers such resilience by preserving the neuronal expression of myocyte enhancer factor 2c.

Joe C. Udeochu
Sadaf Amin
Li Gan
ResearchOpen Access24 Apr 2023
Nature Neuroscience

Volume: 26, P: 737-750
Instructional Film Research in Pennsylvania

C. DENIS PEGGE
Research19 Sept 1959
Nature

Volume: 184, P: 866-867
Morphology and Development of Respiratory Syncytial Virus in Cell Cultures

J. A. ARMSTRONG
H. G. PEREIRA
R. C. VALENTINE
Research22 Dec 1962
Nature

Volume: 196, P: 1179-1181
The B-Vitamins in Wheat: The Unique Aleurone Layer

J. J. C. HINTON
F. G. PEERS
B. SHAW
Research28 Nov 1953
Nature

Volume: 172, P: 993-995
Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model

Darshpreet Kaur
Amarjot Kaur Grewal
Gaber El-Saber Batiha
ResearchOpen Access07 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Erratum: Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

M. Mishina
T. Takai
B. Sakmann
Research03 Jul 1986
Nature

Volume: 322, P: 90
Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice

Here the authors show in female mice at mid-life that deletion of estrogen receptor β in astrocytes induced cognitive impairment, hippocampal atrophy, glial activation and synaptic loss. ERβ ligand treatment restored cognition and decreased neuropathology in these animals.

Noriko Itoh
Yuichiro Itoh
Rhonda R. Voskuhl
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Corrigendum: Near-ultraviolet and visible spectrophotometry of comet Halley from Vega 2

G. Moreels
M. Gogoshev
V. Vanysek
Research03 Jul 1986
Nature

Volume: 322, P: 90
Energy Pathways of Hepatoma No. 5123

ALAN C. AISENBERG
HAROLD P. MORRIS
Research23 Sept 1961
Nature

Volume: 191, P: 1314-1315
Inclusions of Mucopolysaccharide in the Lymphocytes of Patients with Gargoylism

URSULA MITTWOCH
Research23 Sept 1961
Nature

Volume: 191, P: 1315-1316

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