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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In order to predict the behaviours of self-propelled particles it is important to understand the fluid disturbances they generate. Here the authors measure the flow-fields around active particles and show that they are in agreement with theoretical predictions which take into account electrokinetic effects.

Chirality-induced quantum non-reciprocity of cross-channel correlations is demonstrated in a rubidium vapour system by flipping the flow direction of one of the circularly polarized laser beams. It can be extended to multicolour sidebands with Floquet engineering.

Turbulence modelling is an essential flow simulation tool, but is typically dependent on physical insight and engineering intuition. Novati et al. develop a multi-agent reinforcement learning approach for learning turbulence models that can generalize across grid sizes and flow conditions.

Two ‘outrigger’ telescopes were added to CHIME, leading to the localization at detection of FRB 20210603A. The burst originated from deep within the star-forming disk of its host galaxy.

Polymersomes are used as a delivery vehicle for protein, nucleic acid adjuvant and siRNA payloads by enhancing the encapsulation efficiency through copolymer design.

Coherent radio emission with a long (nearly 6.5 h) period has been detected from both magnetic poles of a rotating compact object, offering insights into the evolution and emission mechanism of compact radio transients.

Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally designed artificial FG-Nup that demonstrates that no specific spacer sequence nor a spatial segregation of different FG-motif types are needed to create selective NPCs.

Active flows in biological systems swirl. A coupling between active flows, elongated deformations and defect dynamics helps preserve self-organised structures against disordered swirling.

Polarimetry provides information about physical characteristics of cometary dust. Here, the authors show that the polarization of interstellar comet 2I/Borisov exceeds the typical values for comets, and this together with its polarimetrically homogenous coma suggests a more pristine nature of the object.

Early-Earth geometry models are presented, producing magnetic field intensity and morphologies agreeing with palaeomagnetic data in the deep past and demonstrating the negligible role of fluid viscosity in the Earth’s early geodynamo.

Microtubule asters are positioned precisely within cells by forces generated by molecular motors, but it is unclear how these are integrated in space and time. Here the authors perform in vivo drag measurements and genetic manipulations to determine the balance of forces that position microtubule asters in C. elegans zygotes.

Polarization measurements are reported for the blazar Mk501, revealing a degree of X-ray polarization that is more than twice the optical value and supporting the shock-accelerated energy-stratified electron population scenario.

The authors present 19 detections of coherent low-frequency radio emission from M dwarfs using the Low Frequency Array. The sample includes both chromospherically active and quiescent stars, but radio luminosities are independent of coronal and chromospheric activity indicators.

Shadow tomography is efficient for quantum state characterization. Here, the authors implement shadow tomography on photonic states with a single metasurface, which alleviates the complexity in measurement

Entacapone, a Parkinson’s disease medication, sequesters iron resulting in a selective inhibition of gut microbial activity.

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capillary–venous networks contribute to age-related hypoperfusion and white matter damage in mice.

Quantum control of an optically levitated nanoparticle with a mass of just one femtogram is demonstrated in a cryogenic environment by feedback-cooling the motion of the particle to the quantum ground state.

Structured light is shown to be robust against unitary perturbations.

Most current cell sorting methods are based on fluorescence detection with no imaging capability. Here the authors generate and use Raman image-activated cell sorting with a throughput of around 100 events per second, providing molecular images with no need for labeling.

Mepolizumab (anti-IL-5 therapy) has been shown to reduce type 2 inflammation in asthma. Here the authors use bulk transcriptomics from nasal samples before and after mepolizumab treatment to assess the changes and associations with treatment outcomes.

Non-classically correlated pairs of single photons and phonons are generated and read out from a nanomechanical resonator, demonstrating that such resonators could be used for light–matter quantum interfaces.

The classical description of viscous turbulent flows is based on a formulation of Navier-Stokes equations which assumes its solutions to remain smooth at all times. Saw et al. characterize velocity fields in experimental turbulent flows at dissipative scale, and link the results to the singularities.

X-ray polarization measurements of the Crab nebula and pulsar by the IXPE satellite reveal a global toroidal magnetic field with large variations in local polarization, suggesting a more complex turbulence distribution than anticipated.

Manifold-based model reduction often uses power series expansions that fail to converge on larger domains. Here, authors extend the reach of such approximations using global rational approximants. This enables the reduced models to capture previously inaccessible nonlinear dynamics.

Difficulties in experimentally achieving simultaneous structural sensitivity and time resolution have hindered the real-time mapping of the vibrational energy relaxation pathways in biomacromolecules. Now, using ultrashort light pulses to locally deposit excess energy in a protein-bound haem, the temporal evolution of the subsequent energy flow has been monitored, unravelling vibrational couplings that lead to mode-specific temperature changes.

In vivo imaging is facilitated by a bright, cyan-excitable orange fluorescent protein that is the basis of an improved bioluminescent protein.

The discovery of a long-period radio transient, GPM J1839–10, prompted a search of radio archives, thereby finding that this source has been repeating since at least 1988.

Here, the authors report large photothermal nonlinearity mediated by anapole states within subwavelength Si nanodisks, offering a mechanism for dynamic tuning of far-field radiation from multipolar modes. Nonlinear scattering is used to demonstrate the potential for far-field optical localization of Si nanostructures.

Measurements of an intense radio burst from a Galactic magnetar provide evidence that magnetars are the probable source of some fast radio bursts.

Remote quantum entanglement is demonstrated in a micromachined solid-state system comprising two optomechanical oscillators across two chips physically separated by 20 cm and with an optical separation of around 70 m.

Dissipative optomechanics, once limited to low frequencies, now operates in a sideband-resolved regime, reshaping optical and mechanical spectra and paving the way for the individual addressing of different mechanical modes in a single device.

How material properties affect the functional state of biocondensates is a long-standing question. Here the authors demonstrate how such properties are encoded in a disordered protein sequence and can be predicted from dilute phase conformations.

Here the authors identify a generic coupling in phase-separated liquids between motility and phase equilibria perturbations: phase-separated droplets swim to their dissolution. This suggests alternative transport mechanism for biomolecular condensates.

Turbulent flows are observed in atmosphere, ocean, and technology, with turbulent mixing due to stretching and folding of material elements. The authors analyze a geometric perspective of this process and uncover statistical properties of an ensemble of material loops in a turbulent environment.

An analysis of Zeeman measurements reveals that the reduction of magnetic flux relative to mass, which is necessary for star formation, seems to have occurred earlier than previously thought.

What is the physical limit on entropy production in a suspension of active microswimmers? In answer to this question, the authors derive a general theorem that provides an exact lower bound on the total, external and internal dissipation by a microswimmer and apply it to optimize swimmer shapes.

Rare-earth elements are effective for engineering the optical properties of materials for a range of applications from lasers to quantum information technologies. Here, the authors investigate the temperature-dependent properties of Er³⁺ photoluminescence in Er₂O₃ thin films, focusing on the Stark-Stark transitions and how their temperature-dependent behaviour results from electron-phonon interactions.

Pore-forming toxins are expressed as monomers and assemble into multimeric pores. Here, Benke et al. follow the kinetics of pore formation for the bacterial toxin ClyA with single-molecule methods and show that pore formation progresses through the assembly of oligomeric intermediates, rather than by the addition of monomers to a nascent pore.

One way to describe a particle is as a localised, 3-dimensional topological state, such as a skyrmion or hopfion. Here, the authors demonstrate and characterise particle-like skyrmionic hopfions in a free-space structured light beam.

Stimulated Raman scattering (SRS) microscopy is a quantitative, label-free imaging method to map fat distribution and accumulation with high spatial resolution and sensitivity at both cellular and organism levels.