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Electrocatalytic co-reduction of CO₂ and nitrate to synthesize urea is a sustainable and promising option to the alternative conventional Bosch-Meiser. Here, the authors report a CeO_x-integrated diatomic electrocatalyst overcomes the traditional trade-off between urea yield and Faradaic efficiency.

This study shows that keto-enol tautomerism in 2,4,6-trihydroxybenzaldehyde (Tp) imine COFs acts as variable electron/hole traps, boosting exciton dissociation and charge transfer. Tp COF (TpBpy) achieves an photocatalytic H₂O₂ generation rate of 8350 μmol h^-1 g^-1 under simulated light, and a solar-to-chemical conversion efficiency of 0.038% in a flow reactor under natural sunlight.

Geometric quantum gates—engineered evolution paths for qubit control—promise noise resilience but have shown limited fidelity in prior implementations in semiconductor quantum computation. Here the authors demonstrate high-fidelity single-qubit gates in a single-hole quantum dot in Ge, outperforming conventional dynamical gates.

Chirality has long fascinated chemists, but asymmetric synthesis has largely focused on central, axial, and helical chirality to date. Here, the authors synthesize dianthranilides with planar chirality, via cinchona alkaloid-catalyzed (dynamic) kinetic resolution.

Single-atom catalysts can exhibit improved catalytic performance with respect to their bulk counterparts. Now, the authors introduce a yolk@shell catalyst with spatially separated Pd and Fe single sites that simultaneously catalyse nitroaromatic hydrogenation and alkene epoxidation reactions, leading to a cascade synthesis of amino alcohols.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Here the authors show that China’s carbon neutrality may mitigate global warming by 0.48 °C and 0.40 °C, which account for 14% and 9% of the global warming over the long term under the shared socioeconomic pathway (SSP) 3-7.0 and 5-8.5 scenarios, respectively.

Universal control of the state of qubits on timescales much shorter than the coherence time is necessary for quantum computation. The authors demonstrate electrical control of a charge qubit in quantum dots on the picosecond scale, which is orders of magnitude faster than previously reported.

Charge separation determines the efficiency of semiconductor-based photocatalysts. Here Li et al. show that, in BiVO4, photogenerated electrons and holes accumulate on different crystal facets and the targeted deposition of cocatalysts increases the efficiency of photocatalytic water oxidation.

Establishing multi-degree-of-freedom entangled memories is important for high-capacity quantum communications and computing. Here, authors experimentally demonstrate hyper- and hybrid entanglement between two atomic ensembles in multiple degrees of freedom including path and orbital angular momentum.

A well-designed national coal phase-out pathway in China that considers diverse technology portfolios and plant-level sequential decision-making processes can save over 700 billion dollars and elevate mitigation potential.

Photonic quantum memories are necessary for quantum information networks and can be built using cold atomic gases. In this work, Ding et al. show the first storage and retrieval of single photons carrying orbital angular momentum using electromagnetically induced transparency in a cold rubidium ensemble.

Quantum memories are key components for quantum communication, but current storage times are still too short. Here, the authors use the atomic frequency comb protocol in a zero-first-order-Zeeman field to coherently store an optical pulse for an hour in a cryogenically cooled rare-earth doped crystal.

Edge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.

This study uncovers how seasonal temperature variations influence organic carbon burial in lake sediments. The authors predict that a decline in temperature seasonality will significantly slow or reduce organic carbon burial in lake sediments, leading to carbon emissions and amplified global warming.

A round-robin differential phase shift protocol, in which monitoring of the signal disturbance is unnecessary, has been experimentally realized. With 65 pulses in each packet, the system can distribute a secret key over a distance of 90 km.

Excessive production of reactive oxygen species (ROS) in cancer cells can induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that intermetallics modified with glucose oxidase and soybean phospholipid as nano-inducers promote cancer cell pyroptosis and disulfidptosis, resulting in ICD and anti-tumor immunity in preclinical models.

Synthetically replicating transmembrane protein signal transduction is a gaol of synthetic biology. Here, the authors show how the dimerization of synthetic transmembrane DNA receptors can be used to engineer sensing and actuation cascades in response to external molecular signals.

A quantum memory based on a Raman scheme is implemented for photonic qubits encoded in the path and polarization of single photons. The performance is quantified before and after storage in cold atomic ensembles and the storage bandwidth is ∼140 MHz.

A van der Waals crystal, niobium oxide dichloride, with vanishing interlayer electronic coupling and considerable monolayer-like excitonic behaviour in the bulk, as well as strong and scalable second-order optical nonlinearity, is discovered, which enables a high-performance quantum light source.

The mechanisms directing chromatin remodeling complexes to genomic regions have remained elusive. Here, the authors show that lncRNAs direct SWI/SNF to cell type-specific enhancers, investigating an RNA-mediated layer of targeting specificity.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

B cell activation and differentiation entails metabolic remodelling, involving differential utilisation of monocarboxylates such as L-lactate and pyruvate. Here authors show by B-cell-specific genomic deletion of monocarboxylate transporter 1 (MCT1) that the consequential scarcity of pyruvate results in decreased acetylation of Histone H3 at K27, leading to decreased AID transcription and deficient class switching to IgG.

Divacancy color centers in SiC are promising candidates for a spin-photon interface, but typically show charge-state instability under optical excitation. Here the authors show that modified divacancies created by a focused helium ion beam are robust against photoionization and have promising properties.

Ceramide metabolism has garnered increasing attention in liver diseases, but its role in cholestatic liver injury remains unclear. Here the authors show that targeting ACER3, a ceramidase upregulated in cholestatic liver, alleviates liver injury in mice by enhancing bile acid sulfation to reduce bile acid overload through unsaturated ceramide-activated LXRβ signaling.

Reconfigurable neuromorphic transistors are important for creating compact and efficient neuromorphic computing networks. Here, Li et al. introduce an optoelectronic electrolyte-gated transistor to perform multimodal recognition.

Full-fledged quantum communication networks would allow distributed quantum computing across multiple remote nodes, but typical implementations are stuck at meters-scale distances. Here the authors demonstrate teleportation-based nonlocal CNOT gates, distributed Deutsch-Jozsa algorithm and quantum phase estimation across 7 km space separation.

Detecting genomic structural variants (SVs) using long-read sequencing remains challenging. Here the authors introduce a hybrid pipeline for precise haplotype-resolved SV discovery that outperforms current tools across diverse long-read sequencing datasets.

A van der Waals epitaxial strategy is reported for growing intrinsic quantum dots (QDs) by modulating interfacial couplings on van der Waals surfaces. This method overcomes lattice mismatch constraints and produces versatile III–V and IV–VI QDs with controllable morphologies, broadening near-infrared photoresponse in InSb QDs/MoS₂ by efficient interlayer charge transfer.

MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

Design of all-optical devices rely on large numbers of optical elements and precise control makes this approach challenging. The authors demonstrate that optical devices such as quantum memory and optical filters can be realized using synthetic orbital angular momentum lattices in a single main degenerate cavity.

A wide variety of interesting phenomena arise in 2D systems subject to external gauge fields, but these are sometimes challenging to verify experimentally. Here the authors propose a setup to simulate 2D physics with a 1D arrangement of cavities, by exploiting the orbital angular momentum of trapped photons.

High-throughput computational screening of multicomponent molecular photocatalytic systems offers a strategy to minimize the screening of large numbers of photosensitizer–catalyst combinations. Here a machine learning-accelerated approach using multiple descriptors shows strong predictive power in experimentally validated systems for CO₂ reduction.

Long-read sequencing can greatly improve detection of genomic structural variants (SVs), and numerous methods have been developed to identify SVs using long-read data. Here the authors compare the performance of these methods and provide guidelines to aid users in selecting the most suitable tools for various scenarios.

Crystal structures of PAFR in complex with the antagonist SR 27417 and the inverse agonist ABT-491, together with accompanying experiments, provide insight into recognition of PAF and reveal an unusual ligand-dependent conformation of helical bundle.

The prefrontal cortex is involved in cocaine abuse disorders. Here, the authors show that cocaine suppresses frontal association cortex (FrA) in awake mice and induces locomotor sensitization through a dopamine dependent VTA-vmPFC-FrA pathway.

The NAD⁺ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase, which restricts the virion incorporation of viral proteins and underpins its antiviral effect

Tailoring topological physics in optical cavity is a challenge that would allow new possibilities for the design optical components. In this paper, the authors, harnessing the potential of synthetic dimensions, experimentally demonstrate a degenerate cavity containing many optical angular momenta.

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Bridging the biocatalytic repertoire and the effective environmental remediation remains a great challenge. Here, inspired by the dehalogenases, the authors designed a single atom Co catalyst on carbon doped boron nitride that exhibits high stability and selectivity in dechlorination.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Practical anticounterfeiting labels should possess both high-capacity and robustness, and should allow easy fabrication and readout. Here, the authors show how to heterogeneously grow robust and stable chaotic pattern of diamond microparticles - containing SiV defects - on silicon substrates.

Angle tunability in twisted bilayer graphene is crucial in promoting its applications of twistronics. Here an angle replication strategy is developed to obtain centimetre-scale bilayer graphene with arbitrary twist angles.

Twin-field (TF) quantum key distribution (QKD) over a secure distance of 833.8 km is demonstrated even in the finite-size regime. To this end, an optimized four-phase TF-QKD protocol and a high-speed low-noise TF-QKD system are developed.

Cells contain isolated compartments that spatially confine different enzymes, enabling high-efficiency enzymatic cascade reactions. Herein, the authors report a cell-inspired design of biomimetic cascade catalysis system by immobilizing Fe single atoms and Au nanoparticles on the inner and outer layers of three-dimensional nanocapsules, respectively, to enable highly selective colorimetric glucose detection.

HD-fMOST is a microscopy technique for imaging large samples at high throughput and with high definition, which is achieved with a line-illumination modulation approach. The technology is illustrated by imaging fluorescently labeled neurons in whole mouse brains.

Quantum repeaters are critical components for distributing entanglement over long distances, and they can be improved by the elimination of multi-photon-pair events. Here, the authors demonstrate the storage of single photons emitted by a quantum dot in a polarization maintaining solid-state memory.