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Showing 1–18 of 18 results
Advanced filters: Author: Caroline Bret Clear advanced filters

  • The combination of engineered probes and spectral phasor analysis overcomes long-standing challenges associated with bioluminescence detection at the microscale, enabling multiplexed, real-time imaging of cellular features without the need for excitation light.

    • Zi Yao
    • Caroline K. Brennan
    • Jennifer A. Prescher
    Research
    Nature Methods
    Volume: 19, P: 893-898

  • Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor subtype preference.

    • Madelyn N. Moore
    • Kelsey L. Person
    • Lauren M. Slosky
    ResearchOpen Access
    Nature
    Volume: 648, P: 229-238

  • Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targets. This study provides valuable insights into GID4 functions and a powerful tool for advancing new targeted protein degradation strategies.

    • Dominic D. G. Owens
    • Matthew E. R. Maitland
    • Cheryl H. Arrowsmith
    Research
    Nature Chemical Biology
    Volume: 20, P: 1164-1175

  • Engineering protein biosensors that respond to biomolecules by triggering cellular responses has largely relied on binding rigid molecules. Here, the authors develop a computational strategy for designing signaling complexes between conformationally dynamic proteins and peptides.

    • Robert E. Jefferson
    • Aurélien Oggier
    • Patrick Barth
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Our annual survey highlights startups tackling intractable viruses with new vaccine design, engineering a reliable source of platelets, universalizing cell therapies, improving cancer screening, developing RNA-editing platforms and targeting protein–RNA interactions. Michael Eisenstein, Ken Garber, Caroline Seydel and Laura DeFrancesco report.

    • Michael Eisenstein
    • Ken Garber
    • Laura DeFrancesco
    Special Features
    Nature Biotechnology
    Volume: 38, P: 546-554

  • Cagrilintide is a long-acting agonist of amylin and calcitonin receptors in late phase trials for obesity. Here, authors present structures of cagilintide with each target receptor, revealing the molecular basis for its non-selective action.

    • Jianjun Cao
    • Matthew J. Belousoff
    • Patrick M. Sexton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A multi-ancestry genome-wide association study for age at menarche followed by fine mapping and downstream analysis implicates 665 pubertal timing genes, such as the G-protein-coupled receptor 83 (GPR83) and other genes expressed in the ovaries involved in the DNA damage response.

    • Katherine A. Kentistou
    • Lena R. Kaisinger
    • Ken K. Ong
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1397-1411

  • CDK11 associates with SF3B1 and phosphorylates threonine residues at the N terminus of SF3B1 during spliceosome activation, and the inhibition of CDK11 blocks the activation and leads to widespread intron retention and the accumulation of non-functional spliceosomes on pre-mRNAs and chromatin.

    • Milan Hluchý
    • Pavla Gajdušková
    • Dalibor Blazek
    Research
    Nature
    Volume: 609, P: 829-834

  • Comprehensive mapping of binary protein-protein interactions requires to combine several complementary assays. Here, the authors show that complete coverage could be reached with a minimal number of assays as long as they explore various experimental conditions.

    • Soon Gang Choi
    • Julien Olivet
    • Yves Jacob
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

    • Cyril Pottier
    • Fahri Küçükali
    • Rosa Rademakers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • To perch safely, large birds minimize the distance flown after stalling when swooping up from a dive to a perch, but not the time or energy required.

    • Marco KleinHeerenbrink
    • Lydia A. France
    • Graham K. Taylor
    ResearchOpen Access
    Nature
    Volume: 607, P: 91-96

  • Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

    • Alexandra L Young
    • Razvan V Marinescu
    • Ansgar J Furst
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16