Nature Search

Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates

Sustained epigenetic silencing in monkeys is made more efficient with optimized regulators.

Shaoshuai Mao
Wenbo Peng
Changyang Zhou
Research01 Oct 2025
Nature Biotechnology

P: 1-9
Biomarkers of ageing of humans and non-human primates

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

Zeming Wu
Jing Qu
Guang-Hui Liu
Reviews11 Sept 2025
Nature Reviews Molecular Cell Biology

P: 1-22
RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer

Bone and blood lineage cells communicate each other to maintain skeletal homeostasis. Here authors show that osteolineage RIPK4 couples osteogenesis and myelopoiesis via MFN2 to regulate mitochondrial dynamics.

Peng Ding
Xing Wang
Changqing Zhang
ResearchOpen Access19 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Polar Solomon rings in ferroelectric nanocrystals

Polar Solomon rings in a ferroelectric nanocrystal have been observed and electrically manipulated, which consist of two intertwined vortices and are mathematically equivalent to a \({4}_{1}^{2}\) link in topology based on knots and links theory.

Jing Wang
Deshan Liang
Ce-Wen Nan
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-9
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer

Xiaozhou Xie
Yulong Zhao
Liang Shang
ResearchOpen Access07 Aug 2025
Cell Death & Disease

Volume: 16, P: 1-16
Erratum: A cell-cell communication signal integrates quorum sensing and stress response

Jasmine Lee
Jien Wu
Lian-Hui Zhang
Amendments and Corrections20 May 2013
Nature Chemical Biology

Volume: 9, P: 406
Erratum: Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Min Deng
Ling Wei
Xuejun Zhang
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 714
Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits

DNA methylation data of whole blood from Han Chinese individuals are used to map mQTLs, finding that cis- and trans-mQTLs show distinct patterns of East Asians (EA) ancestry-specific colocalization with complex trait variation.

Qianqian Peng
Xinxuan Liu
Sijia Wang
Research19 Apr 2024
Nature Genetics

Volume: 56, P: 846-860
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia

Zhong et al. show that the protein GP73 stimulates hepatic glucose production and is induced in response to infection with SARS-CoV-2 in vitro and in vivo, thus proposing a molecular mechanism underlying hyperglycemia associated with COVID-19.

Luming Wan
Qi Gao
Hui Zhong
Research06 Jan 2022
Nature Metabolism

Volume: 4, P: 29-43
Tracking CO₂ migration and accumulation in the Subei Basin using geochronology and fluid inclusion quantitative analysis

Yanlong Hu
Ruyue Wang
Yan Yi
ResearchOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1-21
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

Min Deng
Ling Wei
Xuejun Zhang
Research28 Apr 2013
Nature Genetics

Volume: 45, P: 697-700
Electrically and mechanically driven rotation of polar spirals in a relaxor ferroelectric polymer

Polar spirals induced in a relaxor ferroelectric can be quasi-continuously rotated by applying electric/mechanical fields, due to an asymmetric Coulomb interaction. The rotations are non-volatile with robust retention, and can be optically read out.

Mengfan Guo
Erxiang Xu
Yang Shen
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-9
A study on Chinese ancient jades with mercury alteration unearthed from Lizhou’ao Tomb

Yi Bao
Changqing Xu
Yuesheng Li
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Correction to: CCDC12 promotes tumor development and invasion through the Snail pathway in colon adenocarcinoma

Fengying Du
Lipan Peng
Jizhun Zhang
Amendments and CorrectionsOpen Access28 Mar 2022
Cell Death & Disease

Volume: 13, P: 1
A cell-cell communication signal integrates quorum sensing and stress response

IQS is a Pseudomonas aeruginosa quorum sensing molecule that functions during phosphate limitation and lies near the top of the QS signaling hierarchy.

Jasmine Lee
Jien Wu
Lian-Hui Zhang
Research31 Mar 2013
Nature Chemical Biology

Volume: 9, P: 339-343
Momentum-resolved visualization of electronic evolution in doping a Mott insulator

How a Mott insulating state evolves into a conducting or superconducting state is a central issue in doping a Mott insulator and important to understand the physics in high temperature cuprate superconductors. Here, the authors visualize the electronic structure evolution of a Mott insulator within the full Mott gap region and address the fundamental issues.

Cheng Hu
Jianfa Zhao
X. J. Zhou
ResearchOpen Access01 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Efficacy of pulmonary transplantation of engineered macrophages secreting IL-4 on acute lung injury in C57BL/6J mice

Huiying Liu
Yuan He
Changqing Bai
ResearchOpen Access11 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-10
The evolution and pathogenic mechanisms of the rice sheath blight pathogen

The rice sheath blight pathogen, Rhizoctonia solani, is an important fungal pathogen that can devastate rice and maize crops. Zheng and colleagues sequence and assemble the R. solani AG1 IA genome—the first to be sequenced from the Rhizoctoniagenus—using Illumina sequencing technology.

Aiping Zheng
Runmao Lin
Ping Li
ResearchOpen Access29 Jan 2013
Nature Communications

Volume: 4, P: 1-10
The effectiveness of child and adolescent sports engagement in China: an analysis of China’s results for the 2016–2022 Global Matrix report cards on physical activity

Changqing Xiang
Jie Zhao
Normala Ismail
ResearchOpen Access14 Dec 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-12
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

Gane Ka-Shu Wong
Bin Liu
HuanMing Yang
Research09 Dec 2004
Nature

Volume: 432, P: 717-722
Research on stress release and pressure relief mechanism of underlying coal and rock under protective layer mining

Wulin Lei
Jing Chai
Yongchun Gong
ResearchOpen Access15 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis

Juan Xia
Xiaoan Tao
Bin Cheng
ReviewsOpen Access15 Jul 2025
International Journal of Oral Science

Volume: 17, P: 1-14
Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis

Changqing Xie
Zaiye Li
Qianming Chen
ResearchOpen Access12 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-12
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis

Changqing Xie
Liang Zhong
Yongguang Tao
ResearchOpen Access20 Jun 2024
International Journal of Oral Science

Volume: 16, P: 1-14
Atomic origin of the coexistence of high critical current density and high T_c in CuBa₂Ca₃Cu₄O_10+δ superconductors

In this work, a high-T_c (~117 K) joined with a high-J_c (>10⁴ A/cm², 100 K) are reported in the CuBa₂Ca₃Cu₄O_10+δ (Cu-1234) superconductor. Studies have shown that the ordering vacancies and platelike 90° micro-domains serve as efficient microstructure pinning centers which suppress the vortex flux flow and enhance J_c. And plenty of holes with 2p_z symmetry owing to unique compressed [CuO₆] octahedrons decrease superconducting anisotropy and enhance the interlayer coupling that guarantee a high-J_c.

Xuefeng Zhang
Jianfa Zhao
Jing Zhu
ResearchOpen Access10 Jun 2022
NPG Asia Materials

Volume: 14, P: 1-8
CCDC12 promotes tumor development and invasion through the Snail pathway in colon adenocarcinoma

Fengying Du
Lipan Peng
Jizhun Zhang
ResearchOpen Access25 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-9
A novel 3’tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer

Huaiping Cui
Han Li
Leping Li
ResearchOpen Access18 May 2022
Cell Death & Disease

Volume: 13, P: 1-13
ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b

Keming Zhang
Qinbin Zhang
Changqing Li
ResearchOpen Access01 May 2019
Cell Death & Disease

Volume: 10, P: 1-13
The RhHB1/RhLOX4 module affects the dehydration tolerance of rose flowers (Rosa hybrida) by fine-tuning jasmonic acid levels

Youwei Fan
Jitao Liu
Changqing Zhang
ResearchOpen Access02 May 2020
Horticulture Research

Volume: 7, P: 1-13
Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

Penghui Yang
Yingze Zhao
Hai-Xi Sun
Correspondence26 Feb 2021
Cellular & Molecular Immunology

Volume: 18, P: 1064-1066
Liquid biopsy in gastric cancer: predictive and prognostic biomarkers

Zihao Zhang
Hao Wu
Leping Li
ReviewsOpen Access27 Oct 2022
Cell Death & Disease

Volume: 13, P: 1-13

Search

Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates

Biomarkers of ageing of humans and non-human primates

RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer

Polar Solomon rings in ferroelectric nanocrystals

ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer

Erratum: A cell-cell communication signal integrates quorum sensing and stress response

Erratum: Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits

GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia

Tracking CO₂ migration and accumulation in the Subei Basin using geochronology and fluid inclusion quantitative analysis

Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Electrically and mechanically driven rotation of polar spirals in a relaxor ferroelectric polymer

A study on Chinese ancient jades with mercury alteration unearthed from Lizhou’ao Tomb

Correction to: CCDC12 promotes tumor development and invasion through the Snail pathway in colon adenocarcinoma

A cell-cell communication signal integrates quorum sensing and stress response

Momentum-resolved visualization of electronic evolution in doping a Mott insulator

Efficacy of pulmonary transplantation of engineered macrophages secreting IL-4 on acute lung injury in C57BL/6J mice

The evolution and pathogenic mechanisms of the rice sheath blight pathogen

The effectiveness of child and adolescent sports engagement in China: an analysis of China’s results for the 2016–2022 Global Matrix report cards on physical activity

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

Research on stress release and pressure relief mechanism of underlying coal and rock under protective layer mining

Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis

Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis

Atomic origin of the coexistence of high critical current density and high T_c in CuBa₂Ca₃Cu₄O_10+δ superconductors

CCDC12 promotes tumor development and invasion through the Snail pathway in colon adenocarcinoma

A novel 3’tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer

ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b

The RhHB1/RhLOX4 module affects the dehydration tolerance of rose flowers (Rosa hybrida) by fine-tuning jasmonic acid levels

Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

Liquid biopsy in gastric cancer: predictive and prognostic biomarkers

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