Nature Search

Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth

Here the authors identify a nuclear short form of IL-18 in cancer cells that can enhance NK cell activation to promote tumor elimination.

Junchen Shen
Yu Zhang
Guangxun Meng
Research31 Jan 2025
Nature Immunology

Volume: 26, P: 416-428
Antiemetic drug fosaprepitant exerts anti-tumor effects against NSCLC by targeting FAK to inhibit AKT and JNK/c-Jun pathways

Ying Wang
Yu-na Shao
Ze-yi Liu
Research10 Sept 2025
Acta Pharmacologica Sinica

P: 1-15
Heat stress targets and degrades BCR::ABL1 oncoproteins to overcome drug-resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia

Chang Yang
Yuan-Yuan Kang
Hua Naranmandura
Research22 Jul 2025
Leukemia

Volume: 39, P: 2140-2151
Publisher Correction: Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Zhen Wei
Jinglue Song
Wei Yu
Amendments and CorrectionsOpen Access12 Feb 2019
Nature Communications

Volume: 10, P: 1
Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions

Cell membrane interface is mostly studied using synthetic bilayers and reconstituted cell membranes. Here the authors present a new cell fixation method in which the cytoskeleton is replaced by a synthetic hydrogel polymer network assembled inside the cell, thereby preserving the fluid membrane properties after cell death.

Jung-Chen Lin
Chen-Ying Chien
Che-Ming J. Hu
ResearchOpen Access05 Mar 2019
Nature Communications

Volume: 10, P: 1-11
Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover more efficient APC–Asef interaction inhibitors.

Jie Zhong
Yuegui Guo
Jian Zhang
ResearchOpen Access24 Aug 2022
Nature Communications

Volume: 13, P: 1-14
AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner

Weimin Xu
Zhebin Hua
Peng Du
Research29 Feb 2024
Cell Death & Differentiation

Volume: 31, P: 618-634
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis

Hippo signalling is often deregulated in cancers. Here the authors show that CK2 enhances the cooperation of HHEX with YAP-TEAD complex to promote colorectal tumorigenesis.

Yuegui Guo
Zhehui Zhu
Chen-Ying Liu
ResearchOpen Access25 Aug 2022
Nature Communications

Volume: 13, P: 1-17
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Serine hydroxymethyltransferase 2 (SHMT2) converts serine to glycine in mitochondria and is upregulated in a variety of cancers. Here the authors show that acetylation of the lysine-95 (K95) residue negatively regulates SHMT2 expression and activity and is deacetylated by SIRT3 in colorectal cancer.

Zhen Wei
Jinglue Song
Wei Yu
ResearchOpen Access26 Oct 2018
Nature Communications

Volume: 9, P: 1-16
YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer

Zhehui Zhu
Rui Ding
Chen-Ying Liu
ResearchOpen Access28 Jan 2025
Cell Death & Differentiation

Volume: 32, P: 911-925
Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKβ activity

Weimin Xu
Yuegui Guo
Peng Du
ResearchOpen Access03 Sept 2019
Mucosal Immunology

Volume: 12, P: 1291-1303
The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer

Wenbo Tang
Yiqing Yang
Chen-Ying Liu
ResearchOpen Access17 Sept 2024
Oncogene

Volume: 43, P: 3227-3239
Co-inhibition of BET proteins and NF-κB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions

Tingyu Wu
Guanghui Wang
Long Cui
ResearchOpen Access22 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-13
Effects of tumor-infiltrating lymphocytes on nonresponse rate of neoadjuvant chemotherapy in patients with invasive breast cancer

Xiao-Long Qian
Xiao-Qing Xia
Xiao-Jing Guo
ResearchOpen Access07 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer

Zhehui Zhu
Jinglue Song
Long Cui
Research12 May 2020
Oncogene

Volume: 39, P: 4666-4680
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

Xingyou Wan
Chao Wang
Wei Yu
ResearchOpen Access06 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-16
Electrically controlled non-volatile switching of magnetism in multiferroic heterostructures via engineered ferroelastic domain states

(a–c) Reciprocal space maps about (022) reflections of PZN-PT (011) under various poling states, exhibiting various ferroelastic strain states. (d) Electric impulse-induced non-volatile tuning of magnetic anisotropy between the distinct strain states A and B due to the ferroelectric partially coupled ferroelastic domain switching. (e) Hysteresis loops of magnetic resonance fields of FeGaB as a function of the electric field applied on PZN-PT (011), arising from the electric field-induced ferroelectric phase transition from rhombohedral to orthogonal (R–O).

Ming Liu
Tianxiang Nan
Nian X Sun
ResearchOpen Access30 Sept 2016
NPG Asia Materials

Volume: 8, P: e316

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