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Deacetylase-independent HDAC1 condensation defines temozolomide response in glioblastoma

Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner. Disrupting the HDAC1 condensates with resminostat restores the sensitivity to temozolomide.

Qinkai Zhang
Ru Qiu
Wei Zhao
Research09 Jan 2026
Nature Chemical Biology

P: 1-13
Defining heterogeneity in core regulatory circuitry reveals HOXB3 condensation as a potential target in glioblastoma

Zhang et al. delineate the heterogeneity of core regulatory circuitry in glioblastoma and identify HOXB3 condensation as a vulnerability that may be targeted with a therapeutic peptide in mouse models.

Chuanxia Zhang
Yijing He
Wei Zhao
Research30 Sept 2025
Nature Cell Biology

Volume: 27, P: 1848-1862
NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

Rapid detection of diverse biomarkers is crucial for public health. Here, the authors develop NAPTUNE, a versatile platform that identifies multiple nucleic acids and proteins targets within 45 minutes using a nuclease cascade.

Tao Hu
Xinxin Ke
Chunyi Hu
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-16
NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis

The crosstalk between innate immunity and autophagy plays a critical role in cancer. Here, the authors report that an immune receptor NLRP6 potentiates the PI3K/AKT pathway by selective degradation of p85α. The NLRP6-p85α interaction offers a potential therapeutic target for tumor treatment.

Feng Zhi
Bowen Li
Jun Cui
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway

High-quality genomes and single-cell atlases of auditory cortices from microbat and megabat species identify neuronal populations related to ultrasound perception and implicate complexin-1 as a key component of ultrasound transmission in mammals.

Meiling Liu
Changliang Wang
Ji Dong
Research04 Jun 2024
Nature Genetics

Volume: 56, P: 1503-1515
AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma

Jiaming Yu
Chuanxia Zhang
Wei Zhao
ResearchOpen Access17 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-12
Next-generation AI framework for comprehensive oral leukoplakia evaluation and management

JingWen Li
YaFang Zhou
LiWu Zheng
ResearchOpen Access10 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-10
Activities of daily living mediate the association between balance and falls in middle aged and older adults

Jiaran Jiang
Quan Zhou
Keer Cong
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination

Jindong Zhang
Chuanxia Zhang
Rong-Fu Wang
ResearchOpen Access25 May 2017
Cell Death & Disease

Volume: 8, P: e2831

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Deacetylase-independent HDAC1 condensation defines temozolomide response in glioblastoma

Defining heterogeneity in core regulatory circuitry reveals HOXB3 condensation as a potential target in glioblastoma

NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis

Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway

AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma

Next-generation AI framework for comprehensive oral leukoplakia evaluation and management

Activities of daily living mediate the association between balance and falls in middle aged and older adults

TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination

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