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Showing 1–50 of 51 results

Advanced filters: Author: Chunlong Zhang Clear advanced filters

NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

Rapid detection of diverse biomarkers is crucial for public health. Here, the authors develop NAPTUNE, a versatile platform that identifies multiple nucleic acids and proteins targets within 45 minutes using a nuclease cascade.

Tao Hu
Xinxin Ke
Chunyi Hu
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

This work describes the identification of Cas13 proteins from two families by mining public metagenomic data. The newly identified Cas13X.1 shows efficient target knockdown and can be used to degrade SARS-CoV-2 and H1N1 genomes. In addition, the truncated Cas13X.1 offers an advantage in generating mini-RNA base editors.

Chunlong Xu
Yingsi Zhou
Hui Yang
Research03 May 2021
Nature Methods

Volume: 18, P: 499-506
Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

Guoling Li
Xue Dong
Yingsi Zhou
Amendments and CorrectionsOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1
Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model

Duchenne muscular dystrophy (DMD) results from mutations in the DMD. Here the authors report using adenine base editing of exon splice sites to restore dystrophin expression and muscle function in a humanized mouse model of DMD with exon 50 and 51 of mouse DMD gene replaced with human exon 50.

Jiajia Lin
Ming Jin
Guoling Li
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

Miniature gene editing tools are highly desired for efficient in vivo delivery and disease treatment. Here, the authors reported engineering hypercompact TnpB-ωRNA for robust gene editing with minimal off-target effect in cultured cells and use it to rescue fatal genetic liver disease in a tyrosinaemia mouse model.

Zhifang Li
Ruochen Guo
Chunlong Xu
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-11
Physiological and psychological symptom management based on electronic patient-reported outcomes: the TD-WELLBEING randomized clinical trial

Pengyu Jing
Ying Liang
Zhongping Gu
ResearchOpen Access07 Aug 2025
British Journal of Cancer

Volume: 133, P: 937-944
N⁷-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Deregulation of METTL1-mediated N7- methylguanosine tRNA modification can promote oncogenesis. Here, the authors report that this modification regulates the translation of proteins in both the mTOR and negative regulators of autophagy pathways, resulting in the progression of esophageal squamous cell carcinoma.

Hui Han
Chunlong Yang
Shuibin Lin
ResearchOpen Access18 Mar 2022
Nature Communications

Volume: 13, P: 1-15
An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma

Papillary thyroid carcinoma has a heterogenous outcome, particularly in paediatric patients. Here, the authors utilise machine learning to create a protein-based prognostic model to predict recurrence risk.

Zhihong Wang
He Wang
Yaoting Sun
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Self-focusing high-frequency ultrasonic transducers for non-destructive testing applications

Jianxin Zhao
Jialin Hao
Yintang Yang
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.

Huawei Tong
Jia Huang
Hui Yang
Research11 Aug 2022
Nature Biotechnology

Volume: 41, P: 108-119
Regional variations in plantar fascia elasticity and their association with pain in plantar fasciitis: a cross-sectional study

Jiping Zhou
Yuyi Lin
Yulong Wang
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice

Chen Zhang
Juan Li
Le Jia
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
The rising promise of organic photodetectors in emerging technologies

Built on the versatile chemistry of organic semiconductors, organic photodetectors offer efficient thin-film light absorption, mechanical flexibility, spectral tunability and biocompatibility. They are unlocking applications where conformability, seamless integration, human-centric integration and large-area processing are critical.

Kai Zhang
Junjiang Wu
Long Ye
Comments & Opinion12 Jun 2025
Nature Reviews Materials

Volume: 10, P: 487-489
Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

Engineered TadA variants in cytosine base editors (CBEs) offer advantages like smaller size and reduced off-target effects. Here, authors develop an advanced CBE (aTdCBE) through ortholog screening and protein engineering, successfully enabling exon skipping in Duchenne muscular dystrophy model.

Guoling Li
Xue Dong
Yingsi Zhou
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-10
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA for degradation and reducing protein levels in the brain of humanized MECP2-transgenic mice and nonhuman primates.

Dong Yang
Xiaoqing Wu
Hui Yang
Research12 Dec 2024
Nature Neuroscience

Volume: 28, P: 72-83
Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

Biomimetic membranes can be used for various applications such as sensors and separations. Here, Chen et al. report the assembly of lipid-like peptoids into stable and self-repairing 2D membrane nanomaterials that change in thickness when under external stimuli.

Haibao Jin
Fang Jiao
Chun-Long Chen
ResearchOpen Access12 Jul 2016
Nature Communications

Volume: 7, P: 1-8
Valley resolved dynamics of phonon bottleneck in semiconductor molybdenum ditelluride

The effect of multiple energy valleys in the conduction band of semiconductor molybdenum ditelluride on energy dissipation remains unclear. Here, the authors employ time resolved measurements to reveal the pathways and timescales of carrier relaxation and phonon dynamics in different valleys, identifying the phonon bottlenecks of such relaxation.

Zhong Wang
Yijie Shi
Wenxi Liang
ResearchOpen Access23 Aug 2025
Communications Physics

Volume: 8, P: 1-9
Pangenome analysis provides insight into the evolution of the orange subfamily and a key gene for citric acid accumulation in citrus fruits

De novo genome assemblies of 12 species from Aurantioideae and pangenome analyses provide insights into the origin and evolution of the orange subfamily and the genetic basis of flavor in citrus fruits.

Yue Huang
Jiaxian He
Qiang Xu
Research02 Oct 2023
Nature Genetics

Volume: 55, P: 1964-1975
CO₂ dissolution-diffusion in clay inhibitor/oil systems and synergistic CCUS-EOR effects in strongly water-sensitive reservoirs

Miaoxin Zhang
Jingchun Wu
Chunlong Zhang
ResearchOpen Access26 Jul 2025
Scientific Reports

Volume: 15, P: 1-20
Enabling fast-charging selenium-based aqueous batteries via conversion reaction with copper ions

Aqueous battery Se-based cathodes are based on a two-electron transfer electrochemical reaction and generally show inadequate rate capability behaviour. Here, the authors propose a four-electron Se chemistry with copper ions as charge carriers to enable fast-charging battery cycling.

Chunlong Dai
Linyu Hu
Liangti Qu
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-10
Reliability of shear-wave elastography in assessing thoracolumbar fascia elasticity in healthy male

Baizhen Chen
Hongzhou Zhao
Chunlong Liu
ResearchOpen Access17 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
A seamlessly integrated device of micro-supercapacitor and wireless charging with ultrahigh energy density and capacitance

Miniaturized energy storage devices integrated with wireless charging bring opportunities for next generation electronics. Here, authors report seamlessly integrated wireless charging micro-supercapacitors with high energy density capable of driving a model electrical car.

Chang Gao
Jiancheng Huang
Liangti Qu
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-10
Triboelectric effect-modulated varifocal liquid lens

Chunlong Fang
Yuanzhi Cao
Chi Zhang
ResearchOpen Access10 Aug 2020
Microsystems & Nanoengineering

Volume: 6, P: 1-9
Simultaneous determination of cis- and trans-palmitoleic acid in rat serum by UPLC–MS/MS

Wenwen Huang
Yiping Zhang
Zaiwang Zhang
ResearchOpen Access05 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Peroxidase mimics are currently being investigated as catalysts for lignin depolymerisation. In this article, the authors investigate a class of self-assembled and highly stable peptoid/hemin nanomaterials as peroxidase mimics that are highly stable and tuneable for the depolymerisation of a biorefinery lignin.

Tengyue Jian
Yicheng Zhou
Chun-Long Chen
ResearchOpen Access31 May 2022
Nature Communications

Volume: 13, P: 1-13
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

Xiao Xiao
Jiankai Liang
Guangmei Yan
ResearchOpen Access18 Oct 2018
Nature Communications

Volume: 9, P: 1-15
The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases

Haixiu Yang
Desi Shang
Xia Li
ResearchOpen Access27 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans

Transposons are accepted as evolutionary catalysts but how they do so remains less clear. Analyzing 100 animal genomes finds that terminal inverted repeat-type transposable elements catalyze new gene structures and new genes in animals via both transposition-independent and -dependent mechanisms.

Shengjun Tan
Huijing Ma
Yong E. Zhang
ResearchOpen Access13 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering

Peptoids are promising crystallization agents, as they offer the molecular recognition capabilities of proteins and peptides but with higher stability and synthetic tunability. Here, the authors show that sequence-defined peptoids can controllably template the formation and shape evolution of gold nanostructures with defined morphologies.

Feng Yan
Lili Liu
Chun-Long Chen
ResearchOpen Access13 Jun 2018
Nature Communications

Volume: 9, P: 1-8
Tuning crystallization pathways through sequence engineering of biomimetic polymers

AFM measurements of peptoids assembling into sheets and networks show that the crystallization mechanism is determined by the molecular structure, where the addition of a hydrophobic segment alters the crystal formation process into a two-step pathway.

Xiang Ma
Shuai Zhang
James J. De Yoreo
Research17 Apr 2017
Nature Materials

Volume: 16, P: 767-774
Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance

Jiantao Zhang
Yanmei Hu
Jun Wang
ResearchOpen Access15 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Fractal evolution characteristics of fracture meso-damage in uniaxial compression rock masses using bonded block model

Ming Lan
Yan He
Shuwen Zhang
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-20
Comprehensive analysis of the SLC16A gene family in pancreatic cancer via integrated bioinformatics

Shan Yu
Yanshuang Wu
Sheng Tai
ResearchOpen Access30 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Effects of using exposure footwear for firemen and fitness training shoes on lower limb biomechanics during walking

Jianwei Duan
Chunlong Xie
Shengnian Zhang
ResearchOpen Access21 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo

Guixiang Yang
Zixiang Yan
Kailun Fang
Research01 Feb 2023
Gene Therapy

Volume: 30, P: 801-806
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model

Fei Wang
Shuo Zhang
Jing Du
Research26 Jun 2024
Cancer Gene Therapy

Volume: 31, P: 1135-1150
Five hypoxia and immunity related genes as potential biomarkers for the prognosis of osteosarcoma

Dachang Liu
Ziwei Hu
Qingjun Wei
ResearchOpen Access31 Jan 2022
Scientific Reports

Volume: 12, P: 1-16
ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis

Junwei Han
Xinrui Shi
Xia Li
ResearchOpen Access12 Aug 2015
Scientific Reports

Volume: 5, P: 1-15
Chromatin modifications and genomic contexts linked to dynamic DNA methylation patterns across human cell types

Haidan Yan
Dongwei Zhang
Yan Zhang
ResearchOpen Access12 Feb 2015
Scientific Reports

Volume: 5, P: 1-12
Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

This study presents a novel Type I-A CRISPR-Cas3 variant for precise HPV diagnosis. It demonstrates dual activation modes and robustness without stand-alone Cas3 activity, enhancing CRISPR-Cas3 diagnostic applications.

Tao Hu
Quanquan Ji
Chunyi Hu
ResearchOpen Access13 Jul 2024
Communications Biology

Volume: 7, P: 1-12
LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method

Junwei Han
Siyao Liu
Xia Li
ResearchOpen Access20 Apr 2017
Scientific Reports

Volume: 7, P: 1-14
Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case

Wei Liu
Xuefeng Bai
Chunquan Li
ResearchOpen Access19 Aug 2015
Scientific Reports

Volume: 5, P: 1-15
Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network

Qianlan Yao
Yanjun Xu
Xia Li
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Tightly bound and room-temperature-stable excitons in van der Waals degenerate-semiconductor Bi₄O₄SeCl₂ with high charge-carrier density

Excitons – electron-hole bound states important for optoelectronics – are typically observed only in weakly-doped semiconductors or insulators. Here, an exciton with a large binding energy of 375 meV is observed in a highly-doped van der Waals degenerate semiconductor, remaining stable up to room temperature.

Yueshan Xu
Junjie Wang
Zhi-Guo Chen
ResearchOpen Access04 Sept 2023
Communications Materials

Volume: 4, P: 1-10
Deciphering transcriptomic determinants of the divergent link between PD-L1 and immunotherapy efficacy

Anlin Li
Linfeng Luo
Shaodong Hong
ResearchOpen Access11 Sept 2023
npj Precision Oncology

Volume: 7, P: 1-13
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei
Chunlong Xu
Meiling Zhang
CorrespondenceOpen Access01 Feb 2022
Cell Discovery

Volume: 8, P: 1-4
In vivo treatment of tyrosinaemia with hypercompact Cas12f1

Ruochen Guo
Zhifang Li
Chunlong Xu
CorrespondenceOpen Access18 Jul 2023
Cell Discovery

Volume: 9, P: 1-4
Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing

A protocol for quantitative genome-wide detection of replication initiation, fork progression and termination, based on purification and strand-specific sequencing of Okazaki fragments isolated from mammalian or yeast cells.

Xia Wu
Yaqun Liu
Nataliya Petryk
Protocols18 Jan 2023
Nature Protocols

Volume: 18, P: 1260-1295
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Chunlong Ma
Michael Dominic Sacco
Jun Wang
Research15 Jun 2020
Cell Research

Volume: 30, P: 678-692
Conditions and Regulation of Mixed Culture to Promote Shiraia bambusicola and Phoma sp. BZJ6 for Laccase Production

Wen Du
Chunlong Sun
Yanhui Fan
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-13

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