Treating pancreatic cancer can be challenging, as patients often have a poor prognosis and chemoresistance is common. As pancreatic cancer is fundamentally a genetic disease, the authors of this Review emphasize the complex mutational heterogeneity of pancreatic ductal adenocarcinomas and the importance of moving towards a model of tailoring therapies to the specific genetic characteristics of individual tumors.
- Nardin Samuel
- Thomas J. Hudson