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Showing 1–50 of 543 results

Advanced filters: Author: D Connolly Clear advanced filters

The bactericidal FabI inhibitor Debio 1453 clears antibiotic-resistant Neisseria gonorrhoeae infection in vivo

Debio 1453, a FabI inhibitor, shows potent activity against antibiotic-resistant Neisseria gonorrhoeae, rapidly killing bacteria in vitro and clearing infection in mice, supporting its potential for treating drug-resistant gonorrhoea.

Vincent Gerusz
Pierre Regenass
David R. Cameron
ResearchOpen Access18 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

C. Ruwende
S. C. Khoo
A. V. S. Hill
Research20 Jul 1995
Nature

Volume: 376, P: 246-249
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

A structure-guided fragment screen identified a compound, which interacts with a ligand-binding site of unknown function in eukaryotic initiation factor 4E (eIF4E). X-ray crystallography was used to characterise binding and target engagment was shown in cells.

Swee Y. Sharp
Marianna Martella
Paul A. Clarke
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

D. J. Mackay
A. John
D. S. Andersen
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-13
The variety and origin of materials accreted by Bennu’s parent asteroid

Bennu comprises components of intra- and extra-Solar System origins. The parent bodies of Bennu, Ryugu and CI chondrites likely formed from a shared but heterogeneous reservoir in the outer parts of the solar protoplanetary disk.

J. J. Barnes
A. N. Nguyen
D. S. Lauretta
ResearchOpen Access22 Aug 2025
Nature Astronomy

P: 1-18
Hydrogenation of Lipids by Rumen Protozoa

D. E. WRIGHT
Research19 Sept 1959
Nature

Volume: 184, P: 875-876
Carbon and the formation of reduced chondrules

Harold C. Connolly Jr
Roger H. Hewins
Michèle Bourot-Denise
Research08 Sept 1994
Nature

Volume: 371, P: 136-139
Seismotectonics of the Australian Continent

J. R. CLEARY
D. W. SIMPSON
Research26 Mar 1971
Nature

Volume: 230, P: 239-241
Structure and mechanism of copper, zinc superoxide dismutase

John A. Tainer
Elizabeth D. Getzoff
David C. Richardson
Research17 Nov 1983
Nature

Volume: 306, P: 284-287
Mineralogical evidence for hydrothermal alteration of Bennu samples

Samples returned from asteroid Bennu largely comprise hydrated sheet silicates with sulfides, magnetite and carbonate that indicate alteration by a fluid that evolved from neutral to alkaline, according to a micro- and nanoscale mineralogical study.

T. J. Zega
T. J. McCoy
D. S. Lauretta
ResearchOpen Access22 Aug 2025
Nature Geoscience

Volume: 18, P: 832-839
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

John A. Tainer
Elizabeth D. Getzoff
Wayne A. Hendrickson
Research08 Nov 1984
Nature

Volume: 312, P: 127-134
Space weathering effects in Bennu asteroid samples

Material from the Hokioi crater on asteroid Bennu experienced space weathering and suggests microcratering plays a more active role on carbonaceous bodies than initially thought, according to a study of OSIRIS-REx asteroid return samples.

L. P. Keller
M. S. Thompson
D. S. Lauretta
ResearchOpen Access22 Aug 2025
Nature Geoscience

Volume: 18, P: 825-831
Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Shilpa Singh
Catherine E. Gleason
Matthew G. Oser
ResearchOpen Access20 Aug 2025
Nature

P: 1-12
The X-ray structure of an anti-tumour antibody in complex with antigen

Philip D. Jeffrey
Jürgen Bajorath
Steven Sheriff
Research01 Jun 1995
Nature Structural Biology

Volume: 2, P: 466-471
Evolution of the Tasman Sea

J. G. JONES
W. D. ROOTS
Research13 Dec 1974
Nature

Volume: 252, P: 613-614
Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides

Yves Bourne
Barbara Bolgiano
Christian Cambillau
Research01 Dec 1994
Nature Structural Biology

Volume: 1, P: 863-870
Intracellular pH and cytoplasmic free Ca²⁺

W. Siffert
J. W. N. Akkerman
Research04 Jun 1987
Nature

Volume: 327, P: 376
Extractives from West African Members of the Family Meliaceae

C. W. L. BEVAN
D. E. U. EKONG
D. A. H. TAYLOR
Research26 Jun 1965
Nature

Volume: 206, P: 1323-1325
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Esha Madan
António M. Palma
Rajan Gogna
Research09 Dec 2024
Nature Biotechnology

P: 1-15
Lymphocyte Foot Appendage: Its Role in Lymphocyte Function and in Immunological Reactions

WILLIAM McFARLAND
DOROTHY H. HEILMAN
Research27 Feb 1965
Nature

Volume: 205, P: 887-888
Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts

David M. Lawson
Peter J. Artymiuk
Pauline M. Harrison
Research07 Feb 1991
Nature

Volume: 349, P: 541-544
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

Anthony W. Norman
Mathew T. Mizwicki
Derek P. G. Norman
Reviews01 Jan 2004
Nature Reviews Drug Discovery

Volume: 3, P: 27-41
Crystal structure of the apoptosis-inducing human granzyme A dimer

Clara Hink-Schauer
Eva Estébanez-Perpiñá
Dieter E Jenne
Research22 Jun 2003
Nature Structural & Molecular Biology

Volume: 10, P: 535-540
Elimination Of Non-Specific Antibodies From Rabbit Antisera Using Acetone-Precipitated Soluble Proteins

B. SCHMIDT
Y. HOSOKAWA
D. HARTMANN
Research02 Jul 1966
Nature

Volume: 211, P: 32-33
Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

Debra Weinstat-Saslow
Maria J. Merino
Patricia S. Steeg
Research01 Dec 1995
Nature Medicine

Volume: 1, P: 1257-1260
HER2 and urothelial carcinoma: current understanding and future directions

In this Review the authors explore the emerging role of HER2 in urothelial carcinoma, highlighting its biological and clinical significance, the challenges of using HER2 as a biomarker, and the variability and complexity of HER2 assessment. Evidence supporting HER2-targeted therapies and future directions for research and clinical applications are also discussed.

Daniele Raggi
Emanuele Crupi
Matthew D. Galsky
Reviews15 Aug 2025
Nature Reviews Urology

P: 1-23
Different receptors for distribution of peanut and ricin agglutinins between inner and outer segments of rod cells

C. D. B. Bridges
Shao-Ling Fong
Research01 Nov 1979
Nature

Volume: 282, P: 513-515
Mycoplasma pneumoniae adhesin localized to tip structure by monoclonal antibody

J. Feldner
U. Göbel
W. Bredt
Research19 Aug 1982
Nature

Volume: 298, P: 765-767
New type of POU domain in germ line-specific protein Oct-4

Hans R. Schöler
Siegfried Ruppert
Peter Gruss
Research29 Mar 1990
Nature

Volume: 344, P: 435-439
Limiting and realizable efficiencies of solar photolysis of water

James R. Bolton
Stewart J. Strickler
John S. Connolly
Reviews01 Aug 1985
Nature

Volume: 316, P: 495-500
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation

Joshua D. Miller
Heike Wilhelm
Peter Walter
Research25 Dec 1993
Nature

Volume: 366, P: 351-354
An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf
Steven W. Elmore
Saul H. Rosenberg
Research15 May 2005
Nature

Volume: 435, P: 677-681
Silicate dissolution boosts the CO₂ concentrations in subduction fluids

Current estimates of dissolved CO₂ in subduction-zone fluids based on thermodynamic models rely on a very sparse experimental data base. Here, the authors show that experimental graphite-saturated COH fluids interacting with silicates at 1–3 GPa and 800 °C display unpredictably high CO₂ contents.

S. Tumiati
C. Tiraboschi
S. Poli
ResearchOpen Access20 Sept 2017
Nature Communications

Volume: 8, P: 1-11
Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor

Joshua D. Miller
Harris D. Bernstein
Peter Walter
Research17 Feb 1994
Nature

Volume: 367, P: 657-659
Geomagnetic Polarity Change, Volcanic Maxima and Faunal Extinction in the South Pacific

J. P. KENNETT
N. D. WATKINS
Research29 Aug 1970
Nature

Volume: 227, P: 930-934
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model

Roberto Goya-Maldonado
Tracy Erwin-Grabner
Jan Ernsting
ResearchOpen Access03 Oct 2025
Molecular Psychiatry

P: 1-13
5-Hydroxytryptamine in the Circulation of the Dog

D. P. THOMAS
J. R. VANE
Research01 Oct 1967
Nature

Volume: 216, P: 335-338
Initiation of Immune Responses by Small Lymphocytes

J. L. GOWANS
D. D. McGREGOR
C. E. FORD
Research17 Nov 1962
Nature

Volume: 196, P: 651-655
Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

Yanming F. Wang
Stella E. Tsirka
Stuart A. Lipton
Research01 Feb 1998
Nature Medicine

Volume: 4, P: 228-231
Tau protein directly interacts with the amyloid β-protein precursor: Implications for Alzheimer's disease

M.A. Smith
S.L. Siedlak
G. Perry
Research01 Apr 1995
Nature Medicine

Volume: 1, P: 365-369
Structural and mechanistic mapping of a unique fumarate reductase

Paul Taylor
Sara L. Pealing
Malcolm D. Walkinshaw
Research01 Dec 1999
Nature Structural Biology

Volume: 6, P: 1108-1112
Formation of Acid Mucopolysaccharides by Fibroblasts and Serosal Cells

D. LOVELL
A. E. CLARK
R. C. CURRAN
Research11 Jun 1966
Nature

Volume: 210, P: 1173-1174
Colonization of Fresh Waters in the Republic of South Africa by Lymnaea columella Say (Mollusca : Gastropoda)

J. A. VAN EEDEN
D. S. BROWN
Research11 Jun 1966
Nature

Volume: 210, P: 1172-1173
Establishment of a Lunar Unipolar Generator and Associated Shock and Wake by the Solar Wind

C. P. SONETT
D. S. COLBURN
Research01 Oct 1967
Nature

Volume: 216, P: 340-343
Complex precipitation pathways in multicomponent alloys

Emmanuel Clouet
Ludovic Laé
Alexis Deschamps
Research21 May 2006
Nature Materials

Volume: 5, P: 482-488
Hydrogen-bonded frameworks for molecular structure determination

Single crystal X-ray diffraction is an invaluable tool for molecular structure determination, but growing single crystals is often an arduous process. Here the authors find that the structures of a wide array of molecules can be determined by SCXRD when included in hydrogen-bonded guanidinium organosulfonate host frameworks in a single-step crystallization.

Yuantao Li
Sishuang Tang
Michael D. Ward
ResearchOpen Access02 Oct 2019
Nature Communications

Volume: 10, P: 1-7
Biomimetic chiral hydrogen-bonded organic-inorganic frameworks

Assembly is an interesting strategy to build chiral hierarchies with premade properties and functionalities. Here, the authors present assembled chiral hydrogen-bonded organic-inorganic frameworks with dynamical chiroptical activities and employ them as powerful and recoverable platforms for enantioselective recognition of chiral aliphatic substrates.

Jun Guo
Yulong Duan
Yi Liu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-11
Cosmic Rays

G. D. ROCHESTER
Books & Arts17 Jun 1950
Nature

Volume: 165, P: 945-946
Lensing of supernova neutrinos?

John D. Barrow
K. Subramanian
Research04 Jun 1987
Nature

Volume: 327, P: 375
ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease

In human spinal ligament tissue exposed to high stress, fibrotic regions displaying elevated Rho-associated kinase signalling and an increased density of myofibroblasts expressing smooth muscle actin α contribute to degenerative spinal disease.

Muhamed Hadzipasic
Margaret S. Sten
Ganesh M. Shankar
Research29 May 2025
Nature Biomedical Engineering

P: 1-14

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