Nature Search

Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

Biomarkers predictive of response to T cell therapy remain to be better defined. This study identifies potential predictive and pharmacodynamic markers of response to NY-ESO-1 T-cell therapy in a solid tumor that may inform lymphodepletion, cell dose, and strategies to enhance anticancer efficacy.

Alexandra Gyurdieva
Stefan Zajic
Ioanna Eleftheriadou
ResearchOpen Access08 Sept 2022
Nature Communications

Volume: 13, P: 1-18
Night-time reception of solar radio events

N. D'ANGELO
Research02 Jun 1977
Nature

Volume: 267, P: 412
Why measure astrophysical X-ray spectra? (reply)

I. J. D. CRAIG
J. E. BROWN
Research02 Jun 1977
Nature

Volume: 267, P: 411-412
Unified mass imaging maps the lipidome of vertebrate development

uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.

Halima Hannah Schede
Leila Haj Abdullah Alieh
Gioele La Manno
ResearchOpen Access03 Sept 2025
Nature Methods

Volume: 22, P: 1981-1994
Proper solar wind power estimation and planetary radiometric efficiencies (reply)

M. D. DESCH
M. L. KAISER
Research25 Apr 1985
Nature

Volume: 314, P: 756
Proper solar wind power estimation and planetary radiometric efficiencies

D. N. BAKER
L. F. BARGATZE
Research25 Apr 1985
Nature

Volume: 314, P: 755-756
Intake of total and selected carotenoids and colorectal cancer risk: An Italian case-control study

Arianna Natale
Angela D’Angelo
Marta Rossi
ResearchOpen Access17 Sept 2025
European Journal of Clinical Nutrition

P: 1-6
LncRNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation

Cardiomyopathies are linked to dysregulated gene expression. Here, the authors identify the human long noncoding RNA HSCHARME as a disease-associated regulator of cardiomyocyte differentiation, acting through alternative splicing control.

Giulia Buonaiuto
Fabio Desideri
Monica Ballarino
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Potentiation of Narcotic Action by the Brain treated with an Electric Shock

UGO CERLETTI
PAOLO CERLETTI
CARMINE D'ANGELO
Research12 May 1962
Nature

Volume: 194, P: 582-583
Evidence of an upper ionospheric electric field perturbation correlated with a gamma ray burst

Gamma-ray bursts (GRBs) are known to have impact on Earth’s lower ionosphere, but GRB impacts on the upper ionosphere was not observed before. Here, the authors show strong electric field variation at 500 km in the ionosphere caused by GRB221009A.

Mirko Piersanti
Pietro Ubertini
Paolo Zuccon
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-10
Behaviors of lunar regolith simulants under varying gravitational conditions

Ian P. Madden
Sathyashri Muruganandam
Suman Sinha-Ray
ResearchOpen Access01 Oct 2025
npj Microgravity

Volume: 11, P: 1-12
Stress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation

Roberto Tonelli
Raffaella Rizzoni
Alessandro Marchioni
ResearchOpen Access07 Jun 2024
Scientific Reports

Volume: 14, P: 1-13
Effect on the Thyroid Gland of Protracted Administration of Posterior Hypothalamic Extracts

D. BACHRACH
A. LÁSZLÓ
B. KORPÁSSY
Research12 May 1962
Nature

Volume: 194, P: 583
A New Red-Cell Autoantibody in NZB Mice

E. J. HOLBOROW
R. D. S. BARNES
MAUREEN TUFFREY
Research01 Aug 1965
Nature

Volume: 207, P: 601-604
Meta-vinculin—a vinculin-related protein with solubility properties of a membrane protein

Janet D'Angelo Siliciano
Susan W. Craig
Research09 Dec 1982
Nature

Volume: 300, P: 533-535
Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB

CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca²⁺ handling and fusion dynamics are impaired, revealing their dependence on CLPB.

Donato D’Angelo
Víctor H. Sánchez-Vázquez
György Hajnóczky
ResearchOpen Access21 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4⁺ T cell homeostasis

D’Angelo and colleagues show that the nucleoporin Nup210 plays a specific role in naïve CD4⁺ T cell homeostasis by regulating expression of Caveolin-2, which is required for tonic TCR signaling.

Joana Borlido
Stephen Sakuma
Maximiliano A. D’Angelo
Research07 May 2018
Nature Immunology

Volume: 19, P: 594-605
Filopodia are essential for steroid release

Here they show that specialized filopodia are essential for steroid hormone secretion in fruit flies, highlighting a vesicle-mediated mechanism adjusted by filopodia dynamics that challenges a simple secretory diffusion model.

Eléanor Simon
Raphaël Bonche
Nuria Magdalena Romero
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
A computational approach to evaluate how molecular mechanisms impact large-scale brain activity

A computational framework is introduced to study how molecular changes impact brain activity, using biophysically grounded mean-field models to evaluate how drugs acting on synaptic receptors lead to emergent changes in large-scale brain activity.

Maria Sacha
Federico Tesler
Alain Destexhe
ResearchOpen Access28 May 2025
Nature Computational Science

Volume: 5, P: 405-417
Somatosensory cortical-evoked responses after feline experimental spinal cord injury

Philip A Singer
Leon D Prockop
Douglas K Anderson
Research01 Aug 1977
Spinal Cord

Volume: 15, P: 160-165
Nanochemistry at the atomic scale revealed in hydrogen-induced semiconductor surface metallization

Vincent Derycke
Patrick G. Soukiassian
Mathieu G. Silly
Research16 Mar 2003
Nature Materials

Volume: 2, P: 253-258
Prolonged Expiratory Duration with Elevated Lung Volume in Newborn Infants

Ann R Stark
Ivan D Frantz III
Research01 Apr 1979
Pediatric Research

Volume: 13, P: 261-264
The multilayered transcriptional architecture of glioblastoma ecosystems

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

Masashi Nomura
Avishay Spitzer
Itay Tirosh
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1155-1167
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive heterogeneity and microenvironmental co-evolution.

Avishay Spitzer
Kevin C. Johnson
Mario L. Suvà
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1168-1178
Dynamic ice–ocean pathways along the Transpolar Drift amplify the dispersal of Siberian matter

Year-round tracer data from the MOSAiC expedition reveal strong variability in Siberian matter dispersal along the Arctic Transpolar Drift, driven by shifting river inputs and ice–ocean exchange, underscoring complex dynamics in a changing Arctic

Georgi Laukert
Dorothea Bauch
Stephanie S. Kienast
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Unveiling a large fraction of hidden organosulfates in ambient organic aerosol

Solid-phase extraction combined with charged aerosol detection is demonstrated to allow quantification of organosulphates in ambient aerosols without reliance on authentic standards.

Jialiang Ma
Natalie Reininger
Alexander L. Vogel
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-11
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility

L Garzia
A D'Angelo
M Zollo
Research01 Oct 2007
Oncogene

Volume: 27, P: 1853-1864
Mesenchymal cells in health and disease

On 3–8 June 2022, the First International Aegean Conference on Mesenchymal Cells in Health & Disease took place in Chania, Crete, and brought together clinicians and scientists who work on mesenchymal or stromal cell biology across different fields including immunity, inflammation and cancer.

Vasiliki Koliaraki
Gian-Paolo Dotto
George Kollias
News & Views26 Sept 2022
Nature Immunology

Volume: 23, P: 1395-1398
Event-driven figure-ground organisation model for the humanoid robot iCub

Inspired by the primate visual system, this work implements an event-driven, bio-inspired architecture for figure-ground segmentation on the neuromorphic robot iCub, bridging neuromorphic algorithms and software. Its performance is benchmarked on the Berkeley Segmentation Data Set and validated in real-world scenarios.

Giulia D’Angelo
Simone Voto
Chiara Bartolozzi
ResearchOpen Access22 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Glioma tumours are known to be heterogenous in mutation and gene expression patterns, but sampling limitations can lead to inaccurate detection of evolutionary events. Here, the authors carry out multi-omics analysis of multi-regional biopsies from 68 patients and show differential mutations in non-enhancing regions.

Leland S. Hu
Fulvio D’Angelo
Nhan L. Tran
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-20
Morphological Changes following Transplantation and Chronic Obstruction of the Rabbit Appendix

J. A. WILLIAMS
W. O. GRIFFEN JUN.
A. SHARMA
Research02 Dec 1961
Nature

Volume: 192, P: 877-878
Dual-component NMDA receptor currents at a single central synapse

E. D'Angelo
P. Rossi
J. Garthwaite
Research02 Aug 1990
Nature

Volume: 346, P: 467-470
Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: Implications for increased vascular risk

Peck Lin Lip
Andrew D Blann
Gregory Y H Lip
Research01 Mar 1998
Eye

Volume: 12, P: 245-251
Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission

Stefano Masoli
Martina Francesca Rizza
Egidio D’Angelo
ResearchOpen Access12 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
Transforming growth factor–β3 is required for secondary palate fusion

Gabriele Proetzel
Sharon A. Pawlowski
Thomas Doetschman
Research01 Dec 1995
Nature Genetics

Volume: 11, P: 409-414
Phosphatidylinositol-3-OH kinase direct target of Ras

Pablo Rodriguez-Viciana
Patricia H. Warne
Julian Downward
Research18 Aug 1994
Nature

Volume: 370, P: 527-532
Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

Current databases of V genes for antibody repertoire have limitations. Here Corcoran et al. develop a computational approach named IgDiscover that can identify germline V gene sequences from expressed antibody repertoires to high specificity and completeness.

Martin M. Corcoran
Ganesh E. Phad
Gunilla B. Karlsson Hedestam
ResearchOpen Access20 Dec 2016
Nature Communications

Volume: 7, P: 1-14
Reef-building corals farm and feed on their photosynthetic symbionts

Long-term experiments show that corals acquire dissolved inorganic nitrogen and phosphorus by feeding on symbiont cells, which provide essential nutrients enabling their success in nutrient-poor waters.

Jörg Wiedenmann
Cecilia D’Angelo
Amatzia Genin
ResearchOpen Access23 Aug 2023
Nature

Volume: 620, P: 1018-1024
Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

The activity of PD-1 blockade in patients with sarcoma has been modest so far. Here, the authors report the results of a pilot clinical trial to assess the efficacy and safety of bempegaldesleukin, a CD122-preferential interleukin-2 (IL-2) pathway agonist, in combination with the PD1 blockade (nivolumab) in patients with locally advanced or metastatic high-grade sarcoma.

Sandra P. D’Angelo
Allison L. Richards
William D. Tap
ResearchOpen Access16 Jun 2022
Nature Communications

Volume: 13, P: 1-11
An early origin of iron–sulfur cluster biosynthesis machineries before Earth oxygenation

Iron–sulfur (Fe–S) clusters are cofactors essential for life. Combining large-scale phylogenomic analyses with biochemical validation, the authors identify two ancestral minimal Fe–S cluster biogenesis systems and show that they originated before Earth oxygenation.

Pierre Simon Garcia
Francesca D’Angelo
Frédéric Barras
Research15 Sept 2022
Nature Ecology & Evolution

Volume: 6, P: 1564-1572
A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies

The most potent neutralizing antibodies are typically generated from convalescent patients and immunized animals. Here, the authors show it is possible to generate highly potent human neutralizing antibodies against the SARS-CoV-2 spike protein directly from a semisynthetic naïve antibody library.

Fortunato Ferrara
M. Frank Erasmus
Andrew R. M. Bradbury
ResearchOpen Access24 Jan 2022
Nature Communications

Volume: 13, P: 1-12
Global disruption of coral broadcast spawning associated with artificial light at night

This global analysis reveals that artificial light from cities is associated with the disruption of synchronised egg release by corals. This situation could reduce coral reproductive health, hindering conservation efforts in the face of climate change and other anthropogenic impacts.

Thomas W. Davies
Oren Levy
Tim Smyth
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-7
Single-cell lipidomics reveals the organizing principle of cell fate decision

In this Tools of the Trade article, Laura Capolupo (at D’Angelo lab) describes the approach to study cell-to-cell heterogeneity in lipid content and its correspondence to cell identity.

Laura Capolupo
Research Highlights13 Mar 2023
Nature Reviews Molecular Cell Biology

Volume: 24, P: 377
An explainable longitudinal multi-modal fusion model for predicting neoadjuvant therapy response in women with breast cancer

Deep learning for medical image analysis is a promising new avenue to predict treatment response, however the clinical application of these methods has been so far limited. Here, the authors propose a model to predict chemotherapy response in breast cancer in real world clinical settings.

Yuan Gao
Sofia Ventura-Diaz
Ritse Mann
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Predictions for Uranus from a radiometric Bode's law

M. D. Desch
M. L. Kaiser
Research30 Aug 1984
Nature

Volume: 310, P: 755-757
Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

Zafar I. Bashir
Simon Alford
Graham L. Collingridge
Research10 Jan 1991
Nature

Volume: 349, P: 156-158
Rapid eruption of the Deccan flood basalts at the Cretaceous/Tertiary boundary

R. A. Duncan
D. G. Pyle
Research30 Jun 1988
Nature

Volume: 333, P: 841-843
Polarized sorting of glypiated proteins in hippocampal neurons

Carlos G. Dotti
Robert G. Parton
Kai Simons
Research10 Jan 1991
Nature

Volume: 349, P: 158-161
Constancy of oceanic deposition of ¹⁰Be as recorded in manganese crusts

T. L. Ku
M. Kusakabe
I. Nowikow
Research16 Sept 1982
Nature

Volume: 299, P: 240-242
Author Correction: Reef-building corals farm and feed on their photosynthetic symbionts

Jörg Wiedenmann
Cecilia D’Angelo
Amatzia Genin
Amendments and CorrectionsOpen Access11 Sept 2023
Nature

Volume: 621, P: E44

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