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Showing 1–50 of 198 results

Advanced filters: Author: D Farrar Clear advanced filters

Trastuzumab deruxtecan in HER2-low metastatic breast cancer: long-term survival analysis of the randomized, phase 3 DESTINY-Breast04 trial

This prespecified updated survival and exploratory subgroup efficacy analysis of the phase 3 DESTINY-Breast04 trial shows that trastuzumab deruxtecan treatment in patients with HER2-low metastatic breast cancer leads to continuous survival benefit irrespective of estrogen receptor or hormone receptor status.

Shanu Modi
William Jacot
David Cameron
ResearchOpen Access08 Oct 2025
Nature Medicine

P: 1-9
Disentangling degradation pathways of narrow bandgap lead-tin perovskite material and photovoltaic devices

The poor stability of narrow bandgap lead-tin perovskites hinders their implementation in multi junction cells. Here, the authors reveal that device performance degradation is caused by an increase in either mobile ion or background hole density, depending on the hole transport material used.

Florine M. Rombach
Akash Dasgupta
Henry J. Snaith
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Force and Oxygen Consumption in the Immature Rabbit Heart

Mark D Parrish
Scott Farrar
Research01 May 1990
Pediatric Research

Volume: 27, P: 476-482
A gene for Stargardt's disease (fundus flavimaculatus) maps to the short arm of chromosome 1

Josseline Kaplan
Sylvie Gerber
Arnold Munnich
Research01 Nov 1993
Nature Genetics

Volume: 5, P: 308-311
Forest-killing diffuse CO₂ emission at Mammoth Mountain as a sign of magmatic unrest

C. D. Farrar
M. L. Sorey
J. R. Southon
Research24 Aug 1995
Nature

Volume: 376, P: 675-678
Caledonian Magmatism in North Wales

J. E. THOMAS
M. H. DODSON
G. FERRARA
Research26 Feb 1966
Nature

Volume: 209, P: 866-868
Effect of IFN-γ on the immune response in vivo and on gene expression in vitro

Masataka Nakamura
Tim Manser
Malcolm L. Gefter
Research26 Jan 1984
Nature

Volume: 307, P: 381-382
Detection of ⁴He in stratospheric particles gives evidence of extraterrestrial origin

R. S. RAJAN
D. E. BROWNLEE
R. A. BRITTEN
Research12 May 1977
Nature

Volume: 267, P: 133-134
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation

Farrar and colleagues perform an extensive analysis of Ncor1/2 function in B cell development. Loss of both genes results in defective pre-BCR signaling, increased accessibility of STAT5 chromatin motifs and inappropriate Rag gene expression, leading to accelerated leukemic transformation.

Robin D. Lee
Todd P. Knutson
Michael A. Farrar
Research31 Oct 2022
Nature Immunology

Volume: 23, P: 1763-1776
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA_A receptor α₁ subtype

R. M. McKernan
T. W. Rosahl
P. J. Whiting
Research01 Jun 2000
Nature Neuroscience

Volume: 3, P: 587-592
Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

Vikram R. Rao
George B. Cohen
Daniel D. Oprian
Research17 Feb 1994
Nature

Volume: 367, P: 639-642
γ-Interferon is one of several direct B cell-maturing lymphokines

Charles L. Sidman
Jan D. Marshall
Howard M. Johnson
Research28 Jun 1984
Nature

Volume: 309, P: 801-804
Early Precambrian oxygen: a case against photosynthesis

Kenneth M. Towe
Research17 Aug 1978
Nature

Volume: 274, P: 657-661
Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

J. David Farrar
Janice D. Smith
Kenneth M. Murphy
Research01 Jul 2000
Nature Immunology

Volume: 1, P: 65-69
Charles Gaine (1827-1914) - an orthodontic pioneer in Brighton and Bath

Chris Stephens
Sophie Riches
Research13 Aug 2021
British Dental Journal

Volume: 231, P: 191-196
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Reversible mitochondrial stress leading to improved mitochondrial function (mitohormesis) has been reported as an anti-aging mechanism. Here the authors report that harmol (a beta-carboline compound) induces mitohormesis in peripheral organs, alleviates aging-related phenotypes in mice, and extends lifespan in invertebrate models.

Luis Filipe Costa-Machado
Esther Garcia-Dominguez
Pablo J. Fernandez-Marcos
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-22
Response of the Vaginal Epithelium of the Ovariectomized Mouse to the Systemic and Local Administration of Œstrone

J. D. BIGGERS
Research22 Nov 1952
Nature

Volume: 170, P: 895-896
Rapid Reduction of Portal Blood Ammonia

O. W. WENDEL
E. M. BROPHY
Research04 Feb 1961
Nature

Volume: 189, P: 404-405
Solution for the Sherborne problem

C. B. Stringer
F. d'Errico
R. Hedges
Research30 Nov 1995
Nature

Volume: 378, P: 452
An Apparatus for Low-Temperature Dialysis

J. S. FALCONER
D. B. TAYLOR
Research15 Jul 1944
Nature

Volume: 154, P: 87-88
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival

Transcription factors compete for superenhancer sites and have antagonist functions. Farrar and colleagues identify regulatory competition between STAT5 and IKAROS or NF-κB in B cells and show that the ratio of STAT5 to IKAROS or to NF-κB can serve as a prognostic marker of disease severity of the leukemia B-ALL.

Casey D S Katerndahl
Lynn M Heltemes-Harris
Michael A Farrar
Research03 Apr 2017
Nature Immunology

Volume: 18, P: 694-704
Behaviour and speciation of dissolved selenium in estuarine waters

C. I. MEASURES
J. D. BURTON
Research25 May 1978
Nature

Volume: 273, P: 293-295
Do Whales Descend to Great Depths?

F. D. OMMANNEY
Research16 Mar 1935
Nature

Volume: 135, P: 429-430
An Earthquake Investigation Committee

D. KIKUCHI
Research01 Sept 1892
Nature

Volume: 46, P: 418
Prehistoric Epochs

EDMOND BORDAGE
Research01 Sept 1892
Nature

Volume: 46, P: 418
Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

Gordon Keller
Christopher Paige
Erwin F. Wagner
Research14 Nov 1985
Nature

Volume: 318, P: 149-154
Kinetics of the Polymerization of Styrene by Friedel–Crafts Catalysts

D. O. JORDAN
A. R. MATHIESON
Research31 Mar 1951
Nature

Volume: 167, P: 523-524
Effect of Temperature on the R_F Values of the Amino-acids during Paper Chromatography with Solvents completely Miscible with Water

D. P. BURMA
Research29 Sept 1951
Nature

Volume: 168, P: 565-566
Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.

David Porciani
Leah N. Cardwell
Donald H. Burke
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-13
Flexibility and function in HIV-1 protease

Linda K. Nicholson
Toshimasa Yamazaki
Chong-Hwan Chang
Research01 Apr 1995
Nature Structural Biology

Volume: 2, P: 274-280
Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer

Kevin D. Bunting
Mark Y. Sangster
Brian P. Sorrentino
Research01 Jan 1998
Nature Medicine

Volume: 4, P: 58-64
Antibodies targeting Cancer stem cells, A novel pattern in Immunotherapy

Sarfaraz Alam
ResearchOpen Access23 Dec 2010
Nature Precedings

P: 1
Free histidine as a metal chelator in plants that accumulate nickel

Ute Krämer
Janet D. Cotter-Howells
J. Andrew C. Smith
Research15 Feb 1996
Nature

Volume: 379, P: 635-638
Early sCD8 plasma levels during subcutaneous rIl-2 therapy in patients with renal cell carcinoma correlate with response

A Martens
RAJ Janssen
L de Leij
Research01 May 1993
British Journal of Cancer

Volume: 67, P: 1118-1121
Specificity in chaperonin-mediated protein folding

Guoling Tian
Irina E. Vainberg
Nicholas J. Cowan
Research18 May 1995
Nature

Volume: 375, P: 250-253
Pragmatics

S. D. Isard
Books & Arts10 Mar 1977
Nature

Volume: 266, P: 200
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Koen B. Pouwels
David W. Eyre
Chris Cunningham
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Somatostatin-induced inhibition of neuronal Ca²⁺ current modulated by cGMP-dependent protein kinase

Stephen D. Meriney
D. Bruce Gray
Guillermo R. Pilar
Research26 May 1994
Nature

Volume: 369, P: 336-339
Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

Brad H. Nelson
James D. Lord
Philip D. Greenberg
Research26 May 1994
Nature

Volume: 369, P: 333-336
Archaean cratonic roots, mantle shear zones and deep electrical anisotropy

M. Mareschal
R. L. Kellett
R. C. Bailey
Research11 May 1995
Nature

Volume: 375, P: 134-137
A multinational Delphi consensus to end the COVID-19 public health threat

A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Jeffrey V. Lazarus
Diana Romero
Anne Øvrehus
ResearchOpen Access03 Nov 2022
Nature

Volume: 611, P: 332-345
Hydroxyl radical scavengers inhibit human natural killer cell activity

Manikkam Suthanthiran
Scott D. Solomon
Kurt H. Stenzel
Research19 Jan 1984
Nature

Volume: 307, P: 276-278
Milankovitch theory viewed from Devils Hole

J. Imbrie
A. C. Mix
D. G. Martinson
Research10 Jun 1993
Nature

Volume: 363, P: 531-533
Presynaptic Inhibition in Primate Lateral Geniculate Nucleus

JORGE PECCI-SAAVEDRA
PAUL D. WILSON
ROBERT W. DOTY
Research14 May 1966
Nature

Volume: 210, P: 740-742
Repression of c-fos promoter by MyoD on muscle cell differentiation

Didier Trouche
Mikhaïl Grigoriev
Annick Harel-Bellan
Research06 May 1993
Nature

Volume: 363, P: 79-82
A publicly available pharyngitis dataset and baseline evaluations for bacterial or nonbacterial classification

Negar Shojaei
Habib Rostami
Leila Gonbadi
ResearchOpen Access13 Aug 2025
Scientific Data

Volume: 12, P: 1-8
Rb–Sr dating of sphalerites from Tennessee and the genesis of Mississippi Valley type ore deposits

Shun'ichi Nakai
Alex N. Halliday
Henry D. Jones
Research26 Jul 1990
Nature

Volume: 346, P: 354-357
Improving enzyme–electrode contacts by redox modification of cofactors

Azalla Riklin
Eugenii Katz
Andreas F. Bückmann
Research24 Aug 1995
Nature

Volume: 376, P: 672-675
Temporal dynamics of the multi-omic response to endurance exercise training

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

David Amar
Nicole R. Gay
Elena Volpi
ResearchOpen Access01 May 2024
Nature

Volume: 629, P: 174-183
Open-circuit and short-circuit loss management in wide-gap perovskite p-i-n solar cells

A mismatch between quasi-Fermi level splitting and open-circuit voltage is detrimental to wide bandgap perovskite pin solar cells. Here, through theoretical and experimental approaches, the authors optimize n- and p-type interfaces to achieve open-circuit voltage of 1.29 V and T80 of 3500 h at 85 °C.

Pietro Caprioglio
Joel A. Smith
Henry J. Snaith
ResearchOpen Access20 Feb 2023
Nature Communications

Volume: 14, P: 1-13

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