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Showing 1–50 of 245 results

Advanced filters: Author: D G Kirsch Clear advanced filters

Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer’s disease

This study reveals that excitatory–inhibitory imbalance in Alzheimer’s disease is diverse including both impaired long-range synaptic integration and altered local excitability, with distinct links to β-amyloid and tau pathology.

Kamalini G. Ranasinghe
Kiwamu Kudo
Srikantan S. Nagarajan
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-14
A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci

Christopher T. Denny
Yasunobu Yoshikai
Ilan R. Kirsch
Research10 Apr 1986
Nature

Volume: 320, P: 549-551
IQ variations across time and race are explained by literacy differences

David Marks
ResearchOpen Access07 Nov 2007
Nature Precedings

P: 1
IQ variations across time and race are explained by literacy differences

David Marks
ResearchOpen Access15 Nov 2007
Nature Precedings

P: 1
Independence of Amounts of Incorporation of Amino-Acids into Histones on the Amino-Acid Composition of these Proteins

A. S. KONIKOVA
A. V. POGOSOVA
M. G. KRITZMAN
Research13 Apr 1963
Nature

Volume: 198, P: 167-169
Multispecific antibodies

D. J. CAMERON
B. F. ERLANGER
Research01 Feb 1978
Nature

Volume: 271, P: 587-588
An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrids

Ulrich Zechner
Matthias Reule
Reinald Fundele
Research01 Apr 1996
Nature Genetics

Volume: 12, P: 398-403
Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene

Deborah J. Good
Forbes D. Porter
Ilan R. Kirsch
Research01 Apr 1997
Nature Genetics

Volume: 15, P: 397-401
Adjunct-to-insulin therapy using SGLT2 inhibitors in youth with type 1 diabetes: a randomized controlled trial

In a double-blind, randomized, placebo-controlled trial, dapagliflozin, as an adjunct to insulin, resulted in significant reductions in glomerular filtration rate and measures of glycemia when compared to placebo in youth with type 1 diabetes.

Farid H. Mahmud
Petter Bjornstad
David Z. I. Cherney
Research06 Jun 2025
Nature Medicine

Volume: 31, P: 2317-2324
Chromosomal and Serological Studies of the Caenolestidae and their Implications for Marsupial Evolution

D. L. HAYMAN
J. A. W. KIRSCH
P. F. WALLER
Research21 May 1971
Nature

Volume: 231, P: 194-195
The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

Hegazy and colleagues demonstrate that epithelial oncostatin M receptor expression drives gut inflammation and tumor formation.

Roodline Cineus
Yanjiang Luo
Ahmed N. Hegazy
ResearchOpen Access30 May 2025
Nature Immunology

Volume: 26, P: 837-853
Rate of the Reaction of S(3p⁴ ^ID₂) with OCS

R. J. DONOVAN
L. J. KIRSCH
D. HUSAIN
Research21 Jun 1969
Nature

Volume: 222, P: 1164-1165
Odd and even numbered hydrogen ion clusters

D. MATHUR
J. B. HASTED
Research01 Aug 1979
Nature

Volume: 280, P: 573-574
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

Marion M. Nau
Burke J. Brooks
John D. Minna
Research01 Nov 1985
Nature

Volume: 318, P: 69-73
X-ray and energetic neutral particle emission from Saturn's magnetosphere

E. Kirsch
S. M. Krimigis
G. Gloeckler
News & Views20 Aug 1981
Nature

Volume: 292, P: 718-721
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions

Kao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.

Yu-San Kao
Mario Lauterbach
Tim Sparwasser
ResearchOpen Access13 May 2025
Nature Metabolism

Volume: 7, P: 966-984
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

The tumor suppressor p53 is the guardian of the genome. Here, the authors use comprehensive approaches to demonstrate that transient p53 activity induces revival stem cells to promote the regeneration of severely irradiated intestinal epithelium in mice.

Clara Morral
Arshad Ayyaz
David G. Kirsch
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex

An analysis of the localization and intensity of intracortical microstimulation in three participants with cervical spinal cord injury shows that overlapping projected fields from multiple electrodes produce sensations that are more easily localizable.

Charles M. Greenspon
Giacomo Valle
Sliman J. Bensmaia
ResearchOpen Access06 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 935-951
Molecular detection of hybridization between sympatric kangaroo species in south-eastern Australia

L E Neaves
K R Zenger
M D B Eldridge
Research07 Oct 2009
Heredity

Volume: 104, P: 502-512
Ionic basis of the receptor potential in a vertebrate hair cell

D. P. Corey
A. J. Hudspeth
Research25 Oct 1979
Nature

Volume: 281, P: 675-677
Energetic ions in the close environment of Mars and particle shadowing by the planet

V. Afonin
S. McKenna-Lawlor
M. Witte
Research19 Oct 1989
Nature

Volume: 341, P: 616-618
Aberrant rearrangement of the κ light-chain locus involving the heavy-chain locus and chromosome 15 in a mouse plasmacytoma

Brian G. VanNess
Marjorie Shapiro
Frank Ruddle
Research03 Feb 1983
Nature

Volume: 301, P: 425-427
Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae

Soman N. Abraham
Daxi Sun
Edwin H. Beachey
Research15 Dec 1988
Nature

Volume: 336, P: 682-684
Minimum Heart Rates of Marsupials

J. E. KINNEAR
G. D. BROWN
Research30 Sept 1967
Nature

Volume: 215, P: 1501
Chemical modification of a titanium (IV) oxide electrode to give stable dye sensitisation without a supersensitiser

SUSAN ANDERSON
EDWIN C. CONSTABLE
RAYMOND D. WRIGHT
Research01 Aug 1979
Nature

Volume: 280, P: 571-573
Continuous and discontinuous protein antigenic determinants

D. J. Barlow
M. S. Edwards
J. M. Thornton
Research21 Aug 1986
Nature

Volume: 322, P: 747-748
Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Torben Schiffner
Ivy Phung
William R. Schief
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1073-1082
Dependence of Velocity of Structural Breakdown of Injured Cross-striated Muscle Fibres on Time of Denervation

ANNELORE BILSING
Research27 Aug 1966
Nature

Volume: 211, P: 986-987
Normal long bone growth and development in type X collagen-null mice

Rita Rosati
Gerald S. B. Horan
Richard R. Behringer
Research01 Oct 1994
Nature Genetics

Volume: 8, P: 129-135
The Menace to Civilisation: an Appeal to Men of Science

W. D. EVANS
Research15 Sept 1923
Nature

Volume: 112, P: 395-396
Three-dimensional architecture and gating mechanism of a K⁺ channel studied by EPR spectroscopy

Eduardo Perozo
D. Marien Cortes
Luis G. Cuello
Research01 Jun 1998
Nature Structural Biology

Volume: 5, P: 459-469
Genes for immunoglobulin heavy chains and for α₁-antitrypsin are localized to specific regions of chromosome 14q

Diane W. Cox
Vera D. Markovic
Ikuko E. Teshima
Research03 Jun 1982
Nature

Volume: 297, P: 428-430
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Exome sequencing within a structured diagnostic process for rare diseases in Germany shows how facial image analysis and machine learning can guide variant prioritization and uncover many ultrarare diseases.

Axel Schmidt
Magdalena Danyel
Matias Wagner
ResearchOpen Access22 Jul 2024
Nature Genetics

Volume: 56, P: 1644-1653
Rat spermatogenesis in mouse testis

David E. Clouthier
Mary R. Avarbock
Ralph L. Brinster
Research30 May 1996
Nature

Volume: 381, P: 418-421
T-cell apoptosis detected in situ during positive and negative selection in the thymus

Charles D. Surh
Jonathan Sprent
Research03 Nov 1994
Nature

Volume: 372, P: 100-103
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG

S. Amigorena
J. Salamero
C. Bonnerot
Research23 Jul 1992
Nature

Volume: 358, P: 337-341
Non-absorption dips in spectra of γ-ray bursts

J. P. Lasota
B. M. Belli
Research14 Jul 1983
Nature

Volume: 304, P: 139-141
Partial activation of CD8⁺ T cells by a self-derived peptide

Wuxiong Cao
Scott S. Tykodi
Thomas J. Braciale
Research16 Nov 1995
Nature

Volume: 378, P: 295-298
Evidence for a common origin of chloroplasts with light-harvesting complexes of different pigmentation

G. R. Wolfe
F. X. Cunningham
E. Gantt
Research10 Feb 1994
Nature

Volume: 367, P: 566-568
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors

Batista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize the requirements of 10E8 B cell precursors for entry and maturation in the germinal center.

Rashmi Ray
Torben Schiffner
Facundo D. Batista
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1083-1096
Bacterial symbionts support larval sap feeding and adult folivory in (semi-)aquatic reed beetles

Symbiotic microbes in insects can enable their hosts to access untapped nutritional resources. Here, the authors show that symbiotic bacteria in reed beetles can provide essential amino acids to sap-feeding larvae and help leaf-feeding adults to degrade pectin, respectively.

Frank Reis
Roy Kirsch
Martin Kaltenpoth
ResearchOpen Access11 Jun 2020
Nature Communications

Volume: 11, P: 1-15
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

Simon M. Hughes
Laura E. Lillien
Michael Sendtner
Research01 Sept 1988
Nature

Volume: 335, P: 70-73
Systematic position of Plesiadapis

PHILIP D. GINGERICH
Research10 Jan 1975
Nature

Volume: 253, P: 111-113
Upper-crustal strength inferred from stress measurements to 6 km depth in the KTB borehole

Mark D. Zoback
R. Apel
L. Vernik
Research01 Oct 1993
Nature

Volume: 365, P: 633-635
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Activating mutations in Interleukin-7 receptor alpha (IL7Ra) have been reported in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) but its role in leukaemogenesis is not clear. Here, the authors show that activation of IL7Ra in primary human hematopoietic progenitors initiates preleukaemia and cooperates with CDKN2A silencing to develop BCP-ALL.

Ifat Geron
Angela Maria Savino
Shai Izraeli
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-12
Immunoglobulin heavy-chain switching in pre-B leukaemias

Hiromi Kubagawa
Mitsufumi Mayumi
Max D. Cooper
Research27 Jan 1983
Nature

Volume: 301, P: 340-342
A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice

Takeshi Yagi
Shinichi Aizawa
Yoji Ikawa
Research30 Dec 1993
Nature

Volume: 366, P: 742-745
Cell type-specific enhancer element associated with a mouse MHC gene, E_β

Stephen D. Gillies
Virginia Folsom
Susumu Tonegawa
Research16 Aug 1984
Nature

Volume: 310, P: 594-597

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