Nature Search

A monotopic aluminum telluride with an Al=Te double bond stabilized by N-heterocyclic carbenes

As the structure of bulk aluminium chalcogenides is composed of three dimensional networks their molecular congeners exhibit a strong tendency to oligomerize. Here, the authors describe the isolation of a monotopic aluminium telluride and probe its structural and bonding characteristics.

Daniel Franz
Tibor Szilvási
Shigeyoshi Inoue
ResearchOpen Access27 Nov 2015
Nature Communications

Volume: 6, P: 1-6
The subducted component in island arc lavas: constraints from Be isotopes and B–Be systematics

J. D. Morris
W. P. Leeman
F. Tera
Research01 Mar 1990
Nature

Volume: 344, P: 31-36
Intravenous L-Carnitine and Acetyl-L-Carnitine in Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency and Isovaleric Acidemia

J L K Van Hove
S G Kahler
C R Roe
Research01 Jan 1994
Pediatric Research

Volume: 35, P: 96-101
MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane

Microtubules that nucleate from the surface of the Golgi network are important for polarized trafficking and cell migration. Sato et al.find that these microtubules are crosslinked and stabilized by the microtubule-binding protein MTCL1, and show that this activity is required for Golgi structure and function.

Yoshinori Sato
Kenji Hayashi
Atsushi Suzuki
Research04 Nov 2014
Nature Communications

Volume: 5, P: 1-14
Partial radiogenic heat model for Earth revealed by geoneutrino measurements

Relative contributions to Earth’s total heat flux from the radioactive decay of isotopes versus primordial heat are debated. Measurements of geoneutrino particles emitted during radioactive decay in the Earth’s interior indicate that radiogenic isotopes contribute only about half of the total heat flux.

A. Gando
Y. Gando
M. P. Decowski
Research17 Jul 2011
Nature Geoscience

Volume: 4, P: 647-651
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia

Abdel-Wahab and colleagues perform immunophenotyping of AML cells to identify AML-specific surface antigens and show that the RNA helicase U5 snRNP200 represents a therapeutic target for antibody therapy with optimized Fc receptor binding.

Katherine Knorr
Jahan Rahman
Omar Abdel-Wahab
ResearchOpen Access23 Oct 2023
Nature Cancer

Volume: 4, P: 1675-1692
Photoelectrochemical pumping of enzymatic CO₂ reduction

Bruce A. Parkinson
Paul F. Weaver
Research10 May 1984
Nature

Volume: 309, P: 148-149
Carbon-doped SnS₂ nanostructure as a high-efficiency solar fuel catalyst under visible light

Photocatalytic reduction of CO₂ to hydrocarbons is a promising route to both CO₂ utilization and renewable fuel production. Here the authors identify that carbon-doped SnS₂ possesses a high catalytic efficiency towards CO₂ reduction owing to low photogenerated charge recombination rates.

Indrajit Shown
Satyanarayana Samireddi
Kuei-Hsien Chen
ResearchOpen Access12 Jan 2018
Nature Communications

Volume: 9, P: 1-10
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

Chemokine receptors are G protein-coupled receptors (GPCRs) involved in immune responses and characterized by ligand promiscuity Here, the authors characterize signaling through chemokine receptors CXCR4 and CXCR7, with insights into intrinsic-bias encoded in the CXCR4-CXCR7 system.

Parishmita Sarma
Carlo Marion C. Carino
Arun K. Shukla
ResearchOpen Access09 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Resonance region of a PC5 micropulsation examined by a dual auroral radar system

A. D. M. WALKER
R. A. GREENWALD
C. A. GREEN
Research22 Jun 1978
Nature

Volume: 273, P: 646-649
The shape, expansion rate and distance of supernova 1993J from VLBI measurements

N. Bartel
M. F. Bietenholz
R. J. Davis
Research14 Apr 1994
Nature

Volume: 368, P: 610-613
Quantum confinement and light emission in SiO₂/Si superlattices

Z. H. Lu
D. J. Lockwood
J.-M. Baribeau
Research16 Nov 1995
Nature

Volume: 378, P: 258-260
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdomain, thus defining subsequent AT1R phosphorylation patterns, β-arrestin conformation and functionality.

Kouki Kawakami
Masataka Yanagawa
Asuka Inoue
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-16
Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner

How stresses result in cellular senescence is not fully understood. Here, the authors show that cell stress induces the assembly of a polyglutamylated microtubule array connecting nucleus and cilium, which aids in transporting a senescence-inducing protein.

Jielu Hao Robichaud
Yingyi Zhang
Jinghua Hu
ResearchOpen Access12 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Identification of PSR1758 – 23 as a runaway pulsar from the supernova remnant W28

D. A. Frail
S. R. Kulkarni
G. Vasisht
Research09 Sept 1993
Nature

Volume: 365, P: 136-138
Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance

Statistical fine-mapping of mRNA and protein quantitative trait loci in blood samples from the Japan COVID-19 Task Force sheds light on regulatory mechanisms and disease associations.

Qingbo S. Wang
Takanori Hasegawa
Yukinori Okada
ResearchOpen Access24 Sept 2024
Nature Genetics

Volume: 56, P: 2054-2067
A ring-like accretion structure in M87 connecting its black hole and jet

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Ru-Sen Lu
Keiichi Asada
Chen-Yu Yu
ResearchOpen Access26 Apr 2023
Nature

Volume: 616, P: 686-690
Erratum: Changes in spinal cord reflexes after cross-anastomosis of cutaneous and muscle nerves in the adult rat

Stephen B. McMahon
Patrick D. Wall
Amendments and Corrections28 Dec 1989
Nature

Volume: 342, P: 958
Transparent composites for efficient neutron detection

Transparent composites are significant for various applications. Here, the authors propose the co-solidification strategy of crystal and glass melts for preparing transparent glass composite with high crystallinity and apply for neutron detection.

Shichao Lv
Dazhao Wang
Shifeng Zhou
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-9
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody

The cryoEM structures of a single protofilament of FtsZ from Klebsiella pneumoniae (KpFtsZ) in a polymerization-preferred conformation are presented and of a double-helical tube of the FtsZ–monobody complex that shows two parallel protofilaments.

Junso Fujita
Hiroshi Amesaka
Hiroyoshi Matsumura
ResearchOpen Access10 Jul 2023
Nature Communications

Volume: 14, P: 1-13
The radio nebula of the soft γ-ray repeater 1806 – 20

S. R. Kulkarni
D. A. Frail
G. Vasisht
Research10 Mar 1994
Nature

Volume: 368, P: 129-131
Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction

Systematic studies are needed to discover molecular determinants of blood brain barrier dysfunction in Alzheimer’s disease. This study identifies perturbed pericytic SMAD3-astrocytic VEGFA interactions as a potential driver of this dysfunction.

Özkan İş
Xue Wang
Nilüfer Ertekin-Taner
ResearchOpen Access20 Jun 2024
Nature Communications

Volume: 15, P: 1-23
Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist

Sphingosine 1-phosphate receptor 1 (S1PR1) is crucial for lymphocyte trafficking and a target in inflammatory diseases. Here, authors discover KSI6666, a competitive S1PR1 antagonist that suppresses inflammation through pseudoirreversible inhibition.

Yuya Maruyama
Yusuke Ohsawa
Taishin Akiyama
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Bound star clusters observed in a lensed galaxy 460 Myr after the Big Bang

JWST observations of the Cosmic Gems arc resolve the light of an infant galaxy into five gravitationally bound star clusters located in a region smaller than 70 pc.

Angela Adamo
Larry D. Bradley
Yoichi Tamura
ResearchOpen Access24 Jun 2024
Nature

Volume: 632, P: 513-516
Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity

Dietary quality is reported at the global, regional and national level across 185 countries. Though diet quality increased modestly since 1990 at the global level, in South Asia and Sub-Saharan Africa it did not improve. In some regions, children’s dietary quality is lower than that of adults.

Victoria Miller
Patrick Webb
Rubina Hakeem
ResearchOpen Access19 Sept 2022
Nature Food

Volume: 3, P: 694-702
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Hans Häcker
Vanessa Redecke
Michael Karin
Research23 Nov 2005
Nature

Volume: 439, P: 204-207
Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles

Calcineurin–PP1 and PKA acting at excitatory post-synapses reciprocally regulate sleep duration in mice, whereby PKA promotes wakefulness and calcineurin–PP1 promote sleep.

Yimeng Wang
Siyu Cao
Hiroki R. Ueda
Research06 Nov 2024
Nature

Volume: 636, P: 412-421
Mitosis: a history of division

T. J. Mitchison
E. D. Salmon
Reviews01 Jan 2001
Nature Cell Biology

Volume: 3, P: E17-E21
Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes

Brendan Lee
Maurice Godfrey
David W. Hollister
Research25 Jul 1991
Nature

Volume: 352, P: 330-334
Topotecan for Relapsed Small-cell Lung Cancer: Systematic Review and Meta-Analysis of 1347 Patients

Nobuyuki Horita
Masaki Yamamoto
Takeshi Kaneko
ResearchOpen Access21 Oct 2015
Scientific Reports

Volume: 5, P: 1-8
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy

Inherited GPI deficiency (IGD) is caused by PIGO mutations. Here, the authors generate a mouse model of IGD and show that AAV-mediate gene therapy, for knock-in as well as extra-chromosomal expression of Pigo cDNA, ameliorates pathology in the mice.

Ryoko Kuwayama
Keiichiro Suzuki
Yoshiko Murakami
ResearchOpen Access03 Jun 2022
Nature Communications

Volume: 13, P: 1-16
X-ray observations of the 1980 Cygnus X-1 ‘high state’

Y. Ogawara
K. Mitsuda
G. R. Ricker
Research25 Feb 1982
Nature

Volume: 295, P: 675-676
Red-shifting mutation of light-driven sodium-pump rhodopsin

Microbial rhodopsins are photoreceptive and widely used in optogenetics for which they should preferable function with longer-wavelength light. Here, authors achieve a 40-nm red-shift in the absorption wavelength of a sodium-pump rhodopsin (KR2) by altering the distribution of the retinal chromophore.

Keiichi Inoue
María del Carmen Marín
Hideki Kandori
ResearchOpen Access30 Apr 2019
Nature Communications

Volume: 10, P: 1-11
A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

Kathryn J. H. Robson
Jennifer R. S. Hall
D. J. Weatherall
Research01 Sept 1988
Nature

Volume: 335, P: 79-82
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication

Tanaka et al. generate human induced pluripotent stem cell-derived salivary gland organoids that serve as a model for salivary gland development and SARS-CoV-2 infection.

Junichi Tanaka
Hidenobu Senpuku
Kenji Mishima
Research17 Oct 2022
Nature Cell Biology

Volume: 24, P: 1595-1605
Phototrophy by antenna-containing rhodopsin pumps in aquatic environments

Light energy transfer from abundant hydroxylated carotenoids to the retinal moiety of widespread light-driven proton pumps is detected.

Ariel Chazan
Ishita Das
Oded Béjà
Research01 Mar 2023
Nature

Volume: 615, P: 535-540
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Liu and colleagues find differential effects of microglial apoE isoforms on brain function and microglial responses. ApoE3 enhances microglial responses, promoting brain function and reducing amyloid deposition and associated neurotoxicity, while the Alzheimer’s disease-associated apoE4 results in lipid droplet accumulation and impaired microglial responses, which are critical for limiting the development of amyloid pathology.

Chia-Chen Liu
Na Wang
Guojun Bu
Research19 Oct 2023
Nature Immunology

Volume: 24, P: 1854-1866
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Asymmetrical currents and sodium currents in Ranvier nodes exposed to DDT

J. M. DUBOIS
C. BERGMAN
Research21 Apr 1977
Nature

Volume: 266, P: 741-742
Rational design of chemically complex metallic glasses by hybrid modeling guided machine learning

Z. Q. Zhou
Q. F. He
Y. Yang
ResearchOpen Access23 Aug 2021
npj Computational Materials

Volume: 7, P: 1-10
LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates

His-C2-directed modification is chemically challenging and rarely occurs in nature due to the low reactivity of this position. Now, the prenlytransferase LimF has been discovered and applied for geranylation of histidine-containing peptides and imidazole-containing small molecules, showcasing the versatility of this biocatalyst.

Yuchen Zhang
Keisuke Hamada
Hiroaki Suga
Research15 Aug 2022
Nature Catalysis

Volume: 5, P: 682-693
Chromosomal polymorphism and patterns of viability in natural populations of Drosophila melanogaster from cellar and vineyard

A Taberner
A González
Research01 Dec 1991
Heredity

Volume: 67, P: 307-316
Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

The authors highlight the importance of kinetics in GPCR activation. Using solution NMR, they show that the transducer βarrestin1 and the β-arrestin1biased ligand ML314 kinetically tune the conformational ensemble of the neurotensin receptor 1.

Fabian Bumbak
James B. Bower
Joshua J. Ziarek
ResearchOpen Access07 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Selective inhibitors of biosynthesis of aminergic neurotransmitters

J. KOLLONITSCH
A. A. PATCHETT
S. D. ASTER
Research31 Aug 1978
Nature

Volume: 274, P: 906-908
Nucleation and growth of fibres and gel formation in sickle cell haemoglobin

Raymond E. Samuel
E. D. Salmon
Robin W. Briehl
Research28 Jun 1990
Nature

Volume: 345, P: 833-835
Expression and effects of the juvenile hormone esterase in a baculovirus vector

Bruce D. Hammock
Bryony C. Bonning
Susumu Maeda
Research29 Mar 1990
Nature

Volume: 344, P: 458-461
Anthropogenic chlorofluoromethanes in newly formed Labrador Sea Water

D. W. R. Wallace
J. R. N. Lazier
Research03 Mar 1988
Nature

Volume: 332, P: 61-63
Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A₂ at 2.2 Å resolution

J.-P Wery
R. W Schevitz
N. D Jones
Research04 Jul 1991
Nature

Volume: 352, P: 79-82

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