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Enzymes present loops around active sites whose closing and opening dynamics are essential for its activity. Here the authors unveil the mechanism governing loop motion, showing that it involves an activated conformational rearrangement around a couple of torsional angles taking place under the strong friction exerted by the rest of loop torsions.

It is unclear where in the nucleus splicing takes place and how much occurs post-transcriptionally. Using antibodies raised against a phosphorylated splicing factor, Girardet al. show that the majority of splicing occurs co-transcriptionally and that post-transcriptional splicing occurs in nuclear speckles.

The understanding of nucleation and growth of nanostructures plays a key role in complex materials design. Here, the authors illustrate how X-ray in situ studies link transformation at the molecular- and macro- length scales during the emergence of cobalt oxide assemblies.

Controlled switching of the spin state of transition metal ions is key in many enzymatic reactions, but difficult to replicate in synthetic systems. Here the authors report on an iron(III) porphyrin with a photochromic axial ligand that, in solution, reversibly switches between low-spin and high-spin upon irradiation with two different wavelengths.

Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure.

Observing morphological changes of nanoparticles in solution requires advanced in-situ imaging methods. Here, the authors use X-ray ptychography to image the growth and hollowing of Cu₂O nanocubes in 3D.

Long noncoding RNAs regulate tissue-specific gene expression. Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs) and show a role of LEC-specific lncRNA, LETR1, in cell proliferation and migration.

It is commonly assumed that pro-environmental behaviour can be triggered by offering an extrinsic reward. Now research shows that acting pro-environmentally elicits positive feelings and leads people to feel warmer. In experiments, people who learn they act in an environmentally friendly way feel good about themselves and perceive a higher room temperature than people who learn their behaviour is environmentally unfriendly.

Previously documented record values of the fusion triple product in the stellarator Wendelstein 7-X are shown to be evidence for reduced neoclassical energy transport in this optimized device.

Rosenblatt et al. run over 900 million resampling-based simulations in functional and structural connectivity data to show that low and medium effect size predictions require training and external samples in the hundreds to thousands of participants.

East Asia contains “relict” plant species that persist under narrow climatic conditions after once having wider distributions. Here, using distribution records coupled with ecological niche models, the authors identify long-term stable refugia possessing past, current and future climatic suitability favoring ancient plant lineages.

Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure model results in improved cardiac function.

Results from the first experimental campaign of the Wendelstein 7-X stellarator demonstrate that its magnetic-field design grants good control of parasitic plasma currents, leading to long energy confinement times.

X-ray free electron lasers provide high photon flux to explore single particle diffraction imaging of biological samples. Here the authors present dynamic electronic structure calculations and benchmark them to single-particle XFEL diffraction data of sucrose clusters to predict optimal single-shot imaging conditions.

This article reviews recent findings on the optical, electro-optic, and optoelectronic properties of natural and chemically modified DNAs. This review specifically deals with photoluminescence and ET, lasing, NLO, organic light-emitting diode, and photovoltaic characteristics of various compositions based on natural and modified DNAs. Replacement of the Na⁺ counter-ions of natural DNA with functionalized cationic moieties is rapidly broadening the possible utilizations of DNA-based novel materials.

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

Squeezed states of light have been experimentally demonstrated to improve the performance of the Laser Interferometer Gravitational-wave Observatory (LIGO) in astrophysically relevant frequency regions. This enhanced performance may help to reach the sensitivity required for detecting gravitational waves.

Position dependent diffusion coefficients are often estimated indirectly through mean square displacement. The authors propose a diffusion model merging position-dependent coefficients and comb-like trapping mechanisms, revealing that particle trapping mitigates the impact of media heterogeneity and that thus caution is needed in experimental interpretations.

Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans.

‘Squeezed light’ enables quantum noise in one aspect of light to be reduced by increasing the noise, or more accurately the quantum uncertainty, of a complementary aspect. This has now been used to push the detectors at the heart of the GEO600 gravitational wave observatory to unprecedented levels of sensitivity.

A stochastic background of gravitational waves is expected to arise from a superposition of a large number of unresolved gravitational-wave sources and should carry unique signatures from the earliest epochs of the Universe. Limits on the amplitude of the stochastic gravitational-wave background are now reported using the data from a two-year science run of the Laser Interferometer Gravitational-wave Observatory. These limits rule out certain models of early Universe evolution.

Jeff Ross-Ibarra and colleagues report a population genomic analysis of maize evolution. They analyze genome-wide evidence for selection during the initial domestication of wild maize and during the improvement of landraces to modern inbred breeds. Their findings suggest stronger selection during domestication compared to improvement.