Nature Search

Molecular analysis of promoter region of the SMN2 gene in the patients of spinal musculatr atrophy.

Atif Baig
Watihayati Shamsudin
Zilfalil Alwi
ResearchOpen Access30 Nov 2010
Nature Precedings

P: 1
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1

Zangari et al. show that d-cysteine targets NFS1, thus affecting Fe–S cluster biogenesis and impairing tumour growth.

Joséphine Zangari
Oliver Stehling
Jean-Claude Martinou
ResearchOpen Access12 Aug 2025
Nature Metabolism

Volume: 7, P: 1646-1662
Association of dystrophin and an integral membrane glycoprotein

Kevin P. Campbell
Steven D. Kahl
Research16 Mar 1989
Nature

Volume: 338, P: 259-262
Rapid evolution of a unique family of primate ribonuclease genes

Helene F. Rosenberg
Kimberly D. Dyer
Monica Gonzalez
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 219-223
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

Kaloyan M. Tsanov
Francisco M. Barriga
Scott W. Lowe
ResearchOpen Access25 Sept 2025
Nature Cancer

P: 1-18
Role of chiral quantum Hall edge states in nuclear spin polarization

Quantum Hall phases in two-dimensional systems have chiral edges, along which electrons propagate in one direction without backscattering. Here, the authors use nuclear magnetic resonance to demonstrate how chiral modes establish dynamical nuclear polarization in a quantum Hall ferromagnet.

Kaifeng Yang
Katsumi Nagase
Hongwu Liu
ResearchOpen Access20 Apr 2017
Nature Communications

Volume: 8, P: 1-7
The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Human RIF1 protein protects cells from DNA replication stress, through mechanisms that remain uncertain. Here the authors demonstrate that the RIF1-Long isoform interacts with BRCA1 upon extended replication stress, enabling RAD51-dependent repair of broken replication forks.

Qianqian Dong
Matthew Day
Anne D. Donaldson
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-18
A γ-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity

P. Moingeon
S. Jitsukawa
T. Hercend
Research19 Feb 1987
Nature

Volume: 325, P: 723-726
Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes

The authors identify thousands of genetic variants affecting RNA splicing in primary human chondrocytes and link several of them to osteoarthritis risk using genome editing and computational approaches.

Seyoun Byun
Jacqueline Shine
Douglas H. Phanstiel
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-17
An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription

Scott D. Putney
Paul Schimmel
Research25 Jun 1981
Nature

Volume: 291, P: 632-635
ACLY inhibition promotes tumour immunity and suppresses liver cancer

Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of care.

Jaya Gautam
Jianhan Wu
Gregory R. Steinberg
ResearchOpen Access30 Jul 2025
Nature

Volume: 645, P: 507-517
Solid phase transitions as a solution to the genome folding paradox

In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rather than liquid, phase properties.

Joan Pulupa
Natalie G. McArthur
Stavros Lomvardas
Research14 May 2025
Nature

Volume: 643, P: 820-829
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

David D. Schlaepfer
Steven K. Hanks
Peter van der Geer
Research29 Dec 1994
Nature

Volume: 372, P: 786-791
Cryo-EM reveals molecular mechanisms underlying the inhibitory effect of netrin-4 on laminin matrix formation

Netrin-4 is a tumor suppressor that interferes with laminin lattice formation. Here, Kulczyk et al. present a cryo-EM structure of the netrin-4-laminin γ1 complex. The structure reveals how netrin-4 inhibits laminin polymerization and disassembles the laminin matrix.

Arkadiusz W. Kulczyk
Karen K. McKee
Peter D. Yurchenco
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Recognition and initiation site for four late promoters of phage T7 is a 22-base pair DNA sequence

Nikos Panayotatos
Robert D. Wells
Research05 Jul 1979
Nature

Volume: 280, P: 35-39
Intron retention in the Drosophila melanogaster Rieske iron sulphur protein gene generated a new protein

Genomes evolve with time but the molecular mechanisms that underlie this process are poorly understood. Gontijoet al. describe a protein that was generated by the retention of an intron in the Drosophila melanogaster Rieske iron sulphur proteingene and show that the resulting protein is translated.

Alisson M. Gontijo
Veronica Miguela
Maria Dominguez
ResearchOpen Access24 May 2011
Nature Communications

Volume: 2, P: 1-12
Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB

TatA, B and C act together to translocate folded proteins across bacterial and chloroplast membranes, however the precise mechanism remains unclear. Fröbel and colleagues discover that TatC has unforeseen membrane insertase activity, while TatB prevents premature cleavage before translocation.

Julia Fröbel
Patrick Rose
Matthias Müller
ResearchOpen Access18 Dec 2012
Nature Communications

Volume: 3, P: 1-10
Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models

The (G4C2)-RNA hexanucleotide repeat expansion upstream of the start codon of the C9orf72 gene plays a critical role in familial ALS. The authors show that Sig1R, a ligand-regulated molecular chaperone, counteracts the aberrant nucleocytoplasmic distribution of Ran caused by the (G4C2)-RNA repeats.

Pin-Tse Lee
Jean-Charles Liévens
Tsung-Ping Su
ResearchOpen Access04 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

Shih-Feng Tsai
David I. K. Martin
Stuart H. Orkin
Research08 Jun 1989
Nature

Volume: 339, P: 446-451
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

Kazunori Sango
Shoji Yamanaka
Richard L. Proia
Research01 Oct 1995
Nature Genetics

Volume: 11, P: 170-176
Induction of c-fos gene and protein by growth factors precedes activation of c-myc

Rolf Müller
Rodrigo Bravo
Tom Curran
Research20 Dec 1984
Nature

Volume: 312, P: 716-720
Expression of chimaeric genes transferred into plant cells using a Ti-plasmid-derived vector

Luis Herrera-Estrella
Ann Depicker
Jeff Schell
Research19 May 1983
Nature

Volume: 303, P: 209-213
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats

Jingyi Hui
Karl Stangl
Albrecht Bindereif
Research25 Nov 2002
Nature Structural Biology

Volume: 10, P: 33-37
Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target

Despite their differences, the rarer sarcoma CIC::DUX4 sarcoma (CDS) is typically treated with therapies developed for Ewing Sarcoma (EwS) with limited success. Here, the authors develop a co-clinical drug response profiling platform to establish patient-derived CDS and EwS tumoroids, identifying MCL1 inhibition as a promising therapeutic approach in CDS.

Willemijn Breunis
Eva Brack
Marco Wachtel
ResearchOpen Access21 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

The engulfment receptor Draper is known to promote glial clearance of degenerating neurons in Drosophila, and this action of Draper is mediated by Src kinase. This study now shows that one of three Draper isoforms, namely Draper-II, negatively regulates glial clearance and acts in opposition to pro-clearance Draper-I.

Mary A Logan
Rachel Hackett
Marc R Freeman
Research18 Mar 2012
Nature Neuroscience

Volume: 15, P: 722-730
Stabilisation of half MCM ring by Cdt1 during DNA insertion

During pre-Replication Complex, eukaryotic cells load two MCMs into a head-to-head Double Hexamer around duplex DNA (DH). Here the authors preRC assembly assay with purified proteins to reveal insights into S. cerevisiae’s first steps that lead to the DH formation.

Marina Guerrero-Puigdevall
Narcis Fernandez-Fuentes
Jordi Frigola
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-11
Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria

Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native sites, thereby advancing therapeutic antibody development in this host.

Belen Sotomayor
Thomas C. Donahue
Matthew P. DeLisa
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing

This study introduces SDR-seq, a droplet-based single-cell DNA–RNA sequencing platform, enabling the study of gene expression profiles linked to both noncoding and coding variants.

Dominik Lindenhofer
Julia R. Bauman
Lars M. Steinmetz
ResearchOpen Access01 Sept 2025
Nature Methods

Volume: 22, P: 2032-2041
Asymmetric gene conversion at inserted segments on yeast mitochondrial DNA

R. L. Strausberg
R. D. Vincent
R. A. Butow
Research07 Dec 1978
Nature

Volume: 276, P: 577-583
Protection against UV-induced pyrimidine dimerization in DNA by triplex formation

Victor I. Lyamichev
Maxim D. Frank-Kamenetskii
Valery N. Soyfer
Research05 Apr 1990
Nature

Volume: 344, P: 568-570
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

Gabriella D'Orazi
Barbara Cecchinelli
Silvia Soddu
Research03 Dec 2001
Nature Cell Biology

Volume: 4, P: 11-19
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

The CHAMP1 complex, consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin, but its role was unclear. Here, the authors demonstrate that the CHAMP1 complex promotes heterochromatin assembly and homology-directed repair, with its dysfunction linked to CHAMP1 syndrome.

Feng Li
Tianpeng Zhang
Alan D. D’Andrea
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-17
Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

Christian Brechot
Christine Pourcel
Pierre Tiollais
Research31 Jul 1980
Nature

Volume: 286, P: 533-535
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27^Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

Giuseppe Viglietto
Maria Letizia Motti
Massimo Santoro
Research16 Sept 2002
Nature Medicine

Volume: 8, P: 1136-1144
A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization

Atique Ahmed
Jill Thompson
Richard G Vile
Research08 Jun 2003
Nature Biotechnology

Volume: 21, P: 771-777
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

Eukaryotic cells contain membrane-bound organelles that can undergo fusion with each other in a regulated manner; this is thought to be mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors). Here, the complete reconstitution of endosome fusion using Rab5 and SNARE proteins highlights the functional relationship between these two machineries.

Takeshi Ohya
Marta Miaczynska
Marino Zerial
Research20 May 2009
Nature

Volume: 459, P: 1091-1097
Recognition sequence of bacteriophage ΦX174 gene A protein — an initiator of DNA replication

A. D. M. van Mansfeld
S. A. Langeveld
J. H. van Boom
Research11 Dec 1980
Nature

Volume: 288, P: 561-566
Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon

A molecular beacon engineered to be activated by the enzyme apurinic/apyrimidinic endonuclease 1 in inflammatory cells enables the specific and sensitive optical detection of inflammation in live mice.

Chuangui Sheng
Jian Zhao
Lele Li
Research01 Sept 2022
Nature Biomedical Engineering

Volume: 6, P: 1074-1084
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Wulf Tonnus
Francesca Maremonti
Andreas Linkermann
ResearchOpen Access13 Aug 2025
Nature

Volume: 645, P: 1011-1019
A novel mode of RBD-protein recognition in the Y14–Mago complex

Sébastien Fribourg
David Gatfield
Elena Conti
Research05 May 2003
Nature Structural & Molecular Biology

Volume: 10, P: 433-439
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.

K. L. Jønsson
A. Laustsen
M. R. Jakobsen
ResearchOpen Access10 Feb 2017
Nature Communications

Volume: 8, P: 1-17
Adenovirus–mediated in vivo gene transfer and expression in normal rat liver

H. A. Jaffe
C. Danel
R. G. Crystal
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 372-378
Formation of a 2′-phosphomonoester, 3′,5′-phosphodiester linkage by a novel RNA ligase in wheat germ

Maria Konarska
Witold Filipowicz
Hans J. Gross
Research10 Sept 1981
Nature

Volume: 293, P: 112-116
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

Guo-Liang Yu
John D. Bradley
Elizabeth H. Blackburn
Research08 Mar 1990
Nature

Volume: 344, P: 126-132
The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease

Frank Hennecke
Harald Kolmar
Hans-Joachim Fritz
Research24 Oct 1991
Nature

Volume: 353, P: 776-778
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia

In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD⁺ cofactor of UDP-xylose synthase in conditions of low NAD⁺.

Jean Jacobs
Hristiana Lyubenova
Guido T. Bommer
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 218-226
Metastasis-associated protein 1 is an integral component of the circadian molecular machinery

Mammalian circadian clocks modulate the daily cycles of many cellular processes. Here the authors find that metastasis-associated protein 1, which is upregulated in human cancers, is an intrinsic regulator of the mammalian molecular clock.

Da-Qiang Li
Suresh B. Pakala
Rakesh Kumar
Research03 Oct 2013
Nature Communications

Volume: 4, P: 1-13
Primary structure and functional expression from complementary DNA of a brain calcium channel

Yasuo Mori
Thomas Friedrich
Shosaku Numa
Research04 Apr 1991
Nature

Volume: 350, P: 398-402
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

Patricia-E. Falkenburg
Christian Haass
Burkhardt Dahlmann
Research01 Jan 1988
Nature

Volume: 331, P: 190-192
An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution

Understanding the brain’s diversity requires spatially resolved maps of transcripts and proteins. Here, the authors construct an integrated molecular atlas of the mouse hippocampus revealing local enrichment profiles and compartmental organization.

Eva Kaulich
Quinn Waselenchuk
Erin M. Schuman
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-22

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