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Showing 351–399 of 399 results

Advanced filters: Author: D W Ellison Clear advanced filters

How does SIRT1 affect metabolism, senescence and cancer?

The function of protein deacetylase SIRT1 in cancer is controversial: it has been shown to have oncogenic properties as well as tumour suppressor activity. How might these opposing functions be explained?

Christopher L. Brooks
Wei Gu
Reviews29 Dec 2008
Nature Reviews Cancer

Volume: 9, P: 123-128
Vascular permeability in a human tumour xenograft: molecular charge dependence

M Dellian
F Yuan
R K Jain
ResearchOpen Access04 Apr 2000
British Journal of Cancer

Volume: 82, P: 1513-1518
Urinary androgens and breast cancer risk: results from a long-term prospective study based in Guernsey

D Y Wang
D S Allen
M J Reed
ResearchOpen Access04 Apr 2000
British Journal of Cancer

Volume: 82, P: 1577-1584
Biological therapy: approaches in colorectal cancer

AP Zbar
NR Lemoine
WA Kmiot
Reviews01 Mar 1998
British Journal of Cancer

Volume: 77, P: 683-693
Clinical and molecular genetics of patients with the Carney–Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD

Barbara Pasini
Sarah R McWhinney
Constantine A Stratakis
Research01 Aug 2007
European Journal of Human Genetics

Volume: 16, P: 79-88
Treasures and traps in genome-wide data sets: case examples from yeast

Björn Grünenfelder
Elizabeth A. Winzeler
Reviews01 Sept 2002
Nature Reviews Genetics

Volume: 3, P: 653-661
Insights into the impact of sections and departments on your career: The APS-SPR Virtual Chat Series

Stephanie D. Davis
Jeffrey R. Fineman
Joseph W. St. Geme III
Research25 Nov 2021
Pediatric Research

Volume: 92, P: 662-670
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

Alison Hardcastle et al. report a genome-wide meta-analysis of keratoconus, a condition affecting the cornea that causes blurred vision and often leads to blindness. They identify 36 genomic regions associated with keratoconus, 31 of which are novel, and show that the genes in these regions implicate genetic pathways involved in collagen matrix integrity and cell differentiation.

Alison J. Hardcastle
Petra Liskova
Pirro G. Hysi
ResearchOpen Access01 Mar 2021
Communications Biology

Volume: 4, P: 1-13
Microbial legacies alter decomposition in response to simulated global change

Jennifer BH Martiny
Adam C Martiny
Steven D Allison
ResearchOpen Access14 Oct 2016
The ISME Journal

Volume: 11, P: 490-499
PIAS4 is associated with macro/microcephaly in the novel interstitial 19p13.3 microdeletion/microduplication syndrome

Julián Nevado
Jill A Rosenfeld
Pablo Lapunzina
Research08 Apr 2015
European Journal of Human Genetics

Volume: 23, P: 1615-1626
Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production

Kristin Kovach
Megan Davis-Fields
Vernita D Gordon
ResearchOpen Access23 Jan 2017
npj Biofilms and Microbiomes

Volume: 3, P: 1-9
Genome-wide analysis of diamondback moth, Plutella xylostella L., from Brassica crops and wild host plants reveals no genetic structure in Australia

Kym D. Perry
Michael A. Keller
Simon W. Baxter
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-15
Role of NAD⁺ and mitochondrial sirtuins in cardiac and renal diseases

Nicotinamide adenine dinucleotide (NAD⁺) depletion contributes to the pathogenesis of cardiac and renal diseases. Here, the authors review the roles of NAD⁺ in the heart and kidney and discuss the mechanisms by which NAD⁺supplementation might have therapeutic efficacy, with a focus on the role of mitochondrial sirtuins.

Kathleen A. Hershberger
Angelical S. Martin
Matthew D. Hirschey
Reviews06 Feb 2017
Nature Reviews Nephrology

Volume: 13, P: 213-225
Antimalarial drug discovery: efficacy models for compound screening

David A. Fidock
Philip J. Rosenthal
Solomon Nwaka
Reviews01 Jun 2004
Nature Reviews Drug Discovery

Volume: 3, P: 509-520
Identifying eighteenth century pigments at the Bodleian library using in situ Raman spectroscopy, XRF and hyperspectral imaging

R. Mulholland
D. Howell
K. Domoney
ResearchOpen Access18 Oct 2017
Heritage Science

Volume: 5, P: 1-19
Bacterial community dynamics in the hyporheic zone of an intermittent stream

Catherine M Febria
Paul Beddoes
D Dudley Williams
Research08 Dec 2011
The ISME Journal

Volume: 6, P: 1078-1088
Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase

O. Lidor
A. Al-Quntar
D. Steinberg
ResearchOpen Access23 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
Understanding what determines the frequency and pattern of human germline mutations

Mutations that arisede novoin the human germ line are rare, but they contribute significantly to disease. This Review discusses current methods of assessing mutation frequency and examines factors — from nucleotide context and gene function to parental sex and age — that influence mutation patterns.

Norman Arnheim
Peter Calabrese
Reviews01 Jul 2009
Nature Reviews Genetics

Volume: 10, P: 478-488
Global dataset of soil organic carbon in tidal marshes

Tania L. Maxwell
André S. Rovai
Thomas A. Worthington
ResearchOpen Access11 Nov 2023
Scientific Data

Volume: 10, P: 1-14
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases

This Review discusses the structure and function of the blood–brain barrier (BBB) and how brain tumours and brain metastases compromise BBB integrity. It also discusses the challenges the BBB poses for cancer therapy and how these might be overcome.

Costas D. Arvanitis
Gino B. Ferraro
Rakesh K. Jain
Reviews10 Oct 2019
Nature Reviews Cancer

Volume: 20, P: 26-41
Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis

Jared A. Weis
Jessica L. Rauh
Victoria G. Weis
ResearchOpen Access24 Jun 2024
Pediatric Research

Volume: 97, P: 169-177
A platform for interrogating cancer-associated p53 alleles

A D'Brot
P Kurtz
J M Abrams
Research21 Mar 2016
Oncogene

Volume: 36, P: 286-291
The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system

JC Fox
J England
S Little
Research01 Apr 1998
British Journal of Cancer

Volume: 77, P: 1267-1274
Author Correction: Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

Yasmine A. Valentin-Vega
Yong-Dong Wang
J. Paul Taylor
Amendments and CorrectionsOpen Access06 Jun 2024
Scientific Reports

Volume: 14, P: 1-3
The changing face of pathogen discovery and surveillance

The emergence of new microbial infections is ever more likely with the globalization of trade and travel, changes to agricultural practices and climate change. However, as Lipkin describes in this Essay, this threat is being met by dramatic technological advances in pathogen discovery, surveillance and modelling.

W. Ian Lipkin
Comments & Opinion03 Jan 2013
Nature Reviews Microbiology

Volume: 11, P: 133-141
CD3⁻CD4⁺ cells with a Th2-like pattern of cytokine production in the peripheral blood of a patient with cutaneous T cell lymphoma

D Brugnoni
P Airò
R Cattaneo
Correspondence01 Nov 1997
Leukemia

Volume: 11, P: 1983-1985
Discrepancies in reporting the CAG repeat lengths for Huntington's disease

Oliver W Quarrell
Olivia Handley
G Bernhard Landwehrmeyer
Research03 Aug 2011
European Journal of Human Genetics

Volume: 20, P: 20-26
Venezuelan equine encephalitis virus glycoprotein pseudotyping confers neurotropism to lentiviral vectors

A Trabalza
C Georgiadis
N D Mazarakis
Research22 Nov 2012
Gene Therapy

Volume: 20, P: 723-732
Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance

J C Lindsey
D Kawauchi
S C Clifford
Research22 Dec 2014
Oncogene

Volume: 34, P: 4746-4757
Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Nicholas W. Bateman
Tamara Abulez
G. Larry Maxwell
Amendments and CorrectionsOpen Access06 May 2024
npj Precision Oncology

Volume: 8, P: 1
Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma

J C Lindsey
M E Lusher
S C Clifford
ResearchOpen Access19 Jun 2007
British Journal of Cancer

Volume: 97, P: 267-274
Identification of factors that function in Drosophila salivary gland cell death during development using proteomics

C K McPhee
B M Balgley
E H Baehrecke
Research31 Aug 2012
Cell Death & Differentiation

Volume: 20, P: 218-225
Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1

A R Al-Yasi
M J Carroll
K E Britton
ResearchOpen Access12 Mar 2002
British Journal of Cancer

Volume: 86, P: 870-878
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

J W Trampush
M L Z Yang
T Lencz
ResearchOpen Access17 Jan 2017
Molecular Psychiatry

Volume: 22, P: 336-345
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency

M Ceccon
M E Boggio Merlo
C Voena
Research14 Dec 2015
Oncogene

Volume: 35, P: 3854-3865
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells

Ruben D Ramirez
Brittney-Shea Herbert
Jerry W Shay
Research22 Jan 2003
Oncogene

Volume: 22, P: 433-444
Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

Eric Lieberman Greer
Ben Becker
Yang Shi
Research22 Dec 2015
Cell Research

Volume: 26, P: 229-238
Roles of HAUSP-mediated p53 regulation in central nervous system development

N Kon
J Zhong
W Gu
Research25 Feb 2011
Cell Death & Differentiation

Volume: 18, P: 1366-1375
Neurotoxic effects of postnatal thimerosal are mouse strain dependent

M Hornig
D Chian
W I Lipkin
Research08 Jun 2004
Molecular Psychiatry

Volume: 9, P: 833-845
Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse

S H Kim
J W Steele
S Gandy
ResearchOpen Access12 Aug 2014
Molecular Psychiatry

Volume: 19, P: 1235-1242
Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma

W Wang
Q Zhong
R E George
Research22 Jul 2013
Oncogene

Volume: 33, P: 3316-3324
Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O⁶-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum

Linda E Sandercock
Melvin CH Kwok
Frank R Jirik
Research21 Jun 2004
Oncogene

Volume: 23, P: 5931-5940
Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells

R van Rensburg
I Beyer
A Lieber
Research22 Mar 2012
Gene Therapy

Volume: 20, P: 201-214
Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming

S Srinivasan
M Guha
N G Avadhani
Research06 Jul 2015
Oncogene

Volume: 35, P: 1585-1595
Whole-exome sequencing in undiagnosed genetic diseases: interpreting 119 trios

Xiaolin Zhu
Slavé Petrovski
David B. Goldstein
ResearchOpen Access15 Jan 2015
Genetics in Medicine

Volume: 17, P: 774-781
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression

Lauren D Wood
Tanya L Halvorsen
Tej K Pandita
Research12 Mar 2001
Oncogene

Volume: 20, P: 278-288
Switching cell fate, ncRNAs coming to play

D Guan
W Zhang
J C Izpisua Belmonte
ReviewsOpen Access17 Jan 2013
Cell Death & Disease

Volume: 4, P: e464
Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data

Andrew S Allen
Samuel F Berkovic
Melodie R Winawer
Research17 May 2017
European Journal of Human Genetics

Volume: 25, P: 894-899
Evolution of allelic dimorphism in malarial surface antigens

S W Roy
M U Ferreira
D L Hartl
Reviews04 Oct 2006
Heredity

Volume: 100, P: 103-110

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