Nature Search

Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress

Raj and colleagues show that ERX-41 inhibits lipase-independent functions of LIPA and induces ER stress in different tumor types, providing a therapeutic strategy in PDX models of pancreas, ovarian and triple-negative breast cancer.

Xihui Liu
Suryavathi Viswanadhapalli
Ganesh V. Raj
ResearchOpen Access02 Jun 2022
Nature Cancer

Volume: 3, P: 866-884
The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion

In the adrenal cortex, cholesterol used for steroid production is stored in lipid droplets. The authors demonstrate here the importance of the transcription factor HHEX in maintaining glucocorticoid levels and protecting lipid droplets from androgen-induced lipid depletion.

Typhanie Dumontet
Kaitlin J. Basham
Gary D. Hammer
ResearchOpen Access11 Jan 2026
Nature Communications

Volume: 17, P: 1-24
Substrate-assisted enzymatic formation of lysinoalanine in duramycin

During the biosynthesis of the lanthipeptide duramycin, DurN catalyzes stereospecific lysinoalanine formation by preorganizing the reactive conformation of the substrate, such that one of the substrate’s own residues serves as the catalytic base.

Linna An
Dillon P. Cogan
Wilfred A. van der Donk
Research03 Sept 2018
Nature Chemical Biology

Volume: 14, P: 928-933
Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver

Simone Carotti
Daniele Lettieri-Barbato
Umberto Vespasiani-Gentilucci
ResearchOpen Access18 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-10
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Alternatively activated (M2) macrophages use fatty acid oxidation for their metabolic needs. Pearce and colleagues show that triacylglycerols metabolized by lysosomal acid lipase are required for the M2 activation of and function of macrophages.

Stanley Ching-Cheng Huang
Bart Everts
Edward J Pearce
Research03 Aug 2014
Nature Immunology

Volume: 15, P: 846-855
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila

Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with neurons links brain function with the need for rest and sleep.

Andres Flores-Valle
Ivan Vishniakou
Johannes D. Seelig
ResearchOpen Access21 Apr 2025
Nature Neuroscience

Volume: 28, P: 1226-1240
Genetic Variation of Lysosomal Acid Lipase

J A Cortner
P M Coates
J D Schnatz
Research01 Nov 1976
Pediatric Research

Volume: 10, P: 927-932
Observations on Space Irradiation of Individual Crystals of Gas-rich Meteorites

D. LAL
R. S. RAJAN
Research19 Jul 1969
Nature

Volume: 223, P: 269-271
Development and optimization of a female-specific Biomechanical model for biodynamic response analysis: a comparison with male biomechanical models

Veeresalingam Guruguntla
Bonda Atchuta Ganesh Yuvaraju
Hari Prasadarao Pydi
ResearchOpen Access22 Jan 2026
Scientific Reports

Volume: 16, P: 1-17
The global extent of the grassland biome and implications for the terrestrial carbon sink

By combining satellite observations with ground-based data and expert validation, this analysis demonstrates considerable misestimation of grassland extent and thereby carbon stock estimates in previous global assessments based on remote sensing.

A. S. MacDougall
B. Vanzant
M. B. Siewert
Research27 Jan 2026
Nature Ecology & Evolution

Volume: 10, P: 246-257
Natural occurrence of silicon carbide in a diamondiferous kimberlite from Fuxian

Irene Leung
Wenxiang Guo
Jim Gleason
Research26 Jul 1990
Nature

Volume: 346, P: 352-354
Super-heavy Elements in Extraterrestrial Samples

N. BHANDARI
S. G. BHAT
V. S. VENKATAVARADAN
Research26 Mar 1971
Nature

Volume: 230, P: 219-224
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α

The peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) is implicated in regulating the morphology and function of the neuromuscular junction. Here, Arnold et al.show that PGC-1α promotes the remodeling of pre- and postsynaptic neuromuscular junction sites, even in the absence of physical activity.

Anne-Sophie Arnold
Jonathan Gill
Christoph Handschin
Research01 Apr 2014
Nature Communications

Volume: 5, P: 1-11
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Primitive Low-energy Particle Irradiation of Meteoritic Crystals

P. PELLAS
G. POUPEAU
J. AUDOUZE
Research19 Jul 1969
Nature

Volume: 223, P: 272-274
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

Volume: 32, P: 527-544
A competitive disinhibitory network for robust optic flow processing in Drosophila

Navigation relies on detecting left versus right body asymmetries for gaze and course stability. A central three-layer optic flow-sensitive network with competitive lateral disinhibition extracts asymmetries from complex motion patterns.

Mert Erginkaya
Tomás Cruz
M. Eugenia Chiappe
ResearchOpen Access01 May 2025
Nature Neuroscience

Volume: 28, P: 1241-1255
‘Dating’ Ground Waters of Ages Younger than 1,000–1,500 Years Using Natural Silicon-32

V. N. NIJAMPURKAR
B. S. AMIN
D. LAL
Research30 Apr 1966
Nature

Volume: 210, P: 478-480
A Plasmodium-derived nanoparticle vaccine elicits sterile protection against malaria in mice

Plasmodium falciparum proteins were engineered to create a nanoparticle vaccine platform capable of displaying multiple antigens at 48 sites. Displaying a designed malaria circumsporozoite protein immunogen on this platform achieves full sterile protection in mice.

Dashuang Shi
Rui Ma
Niraj H. Tolia
Research19 Dec 2025
Nature Microbiology

Volume: 11, P: 67-80
Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes

A multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human populations.

Xueqing Zoe Zou
Fengyuan Hu
Keren Carss
ResearchOpen Access04 Feb 2026
Nature

P: 1-11
Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo

Here the authors report that brown adipocyte-derived vaspin reduces heat-producing activity in brown fat by blocking adrenergic signals, helping to regulate energy expenditure and maintain metabolic balance.

Inka Rapöhn
Helen Broghammer
Juliane Weiner
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 16, P: 1-15
A Three-Component Radio Source Containing a Well-Aligned Magnetic Field

F. F. GARDNER
R. D. DAVIES
Research11 Jan 1964
Nature

Volume: 201, P: 144-146
Solar flare irradiation records in Antarctic meteorites

J. N. Goswami
Research10 Sept 1981
Nature

Volume: 293, P: 124-125
Health-economic evaluation of a novel personalized digital avatar-based anemia management software in hemodialysis patients

Afschin Gandjour
Dana Kendzia
Jovana Petrovic Vorkapic
ResearchOpen Access03 Jan 2026
npj Digital Medicine

Volume: 9, P: 1-9
Secretory IgM regulates gut microbiota homeostasis and metabolism

Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.

Yang Ding
Alvaro Fernández-Montero
J. Oriol Sunyer
Research23 May 2025
Nature Microbiology

Volume: 10, P: 1431-1446
Cosmogenic ¹⁰Be in Zaire alluvial diamonds: implications for ³He contents of diamonds

D. Lal
K. Nishiizumi
H. Craig
Research09 Jul 1987
Nature

Volume: 328, P: 139-141
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Activation of T cells results in metabolic reprogramming to favour glycolysis. Here, Patsoukis et al. show that the surface receptor PD-1 inhibits glycolysis and increases the metabolism of lipids, providing a potential mechanism for the blockade of T effector functions but also for the longevity accompanying T cell exhaustion.

Nikolaos Patsoukis
Kankana Bardhan
Vassiliki A. Boussiotis
ResearchOpen Access26 Mar 2015
Nature Communications

Volume: 6, P: 1-13
Growth Retardation and Zinc Nutrition

Noel W Solomons
Robert L Rosenfield
Harold H Sandstead
Research01 Nov 1976
Pediatric Research

Volume: 10, P: 923-927
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
A Strong Suppressor Specific for UGA

J. F. SAMBROOK
D. P. FAN
S. BRENNER
Research14 Apr 1967
Nature

Volume: 214, P: 452-453
Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

In this work, authors utilise a prefractionation natural product extract screening platform, which uncovers coniotins, lipopeptaibiotics with broad antifungal activity and a mechanism of action that targets fungal cell wall β-glucan.

Xuefei Chen
Kalinka Koteva
Gerard D. Wright
ResearchOpen Access08 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Chemical Composition of Nuclei of Z > 22 in Cosmic Rays using Meteoritic Minerals as Detectors

D. LAL
R. S. RAJAN
A. S. TAMHANE
Research04 Jan 1969
Nature

Volume: 221, P: 33-37
Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study

G. de-Thé
A. Geser
W. Henle
Research24 Aug 1978
Nature

Volume: 274, P: 756-761
The oxygen isotope effect in Ba_0.625K_0.375BiO₃

D. G. Hinks
D. R. Richards
A. W. Mitchell
Research29 Sept 1988
Nature

Volume: 335, P: 419-421
Propagation of Pulses of Second Sound in Liquid Helium II

D. V. OSBORNE
Research07 Aug 1948
Nature

Volume: 162, P: 213-214
Biological Activity of Masked Endotoxin

Harald Schwarz
Jan Gornicec
Jutta Horejs-Hoeck
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Cosmogenic ³²P and ³³P used as tracers to study phosphorus recycling in the upper ocean

D. Lal
T. Lee
Research23 Jun 1988
Nature

Volume: 333, P: 752-754
Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa

Muhammad Yasir
Debarun Dutta
Mark D. P. Willcox
ResearchOpen Access08 May 2019
Scientific Reports

Volume: 9, P: 1-12
Experimental Decomposition of Algae in Seawater and Early Diagenesis

DONALD C. THORSTENSON
FRED T. MACKENZIE
Research31 Dec 1971
Nature

Volume: 234, P: 543-545
Fossil Tracks in the Meteorite Angra dos Reis: a Predominantly Fission Origin

N. BHANDARI
S. BHAT
V. S. VENKATAVARADAN
Research31 Dec 1971
Nature

Volume: 234, P: 540-543
The sequential use of IVF disposable devices doesn’t cause cumulative toxicity unless a defective device compromises the entire procedure

Lucie Delaroche
Lucile Besnard
Nuno Costa-Borges
ResearchOpen Access20 Jan 2026
Scientific Reports

Volume: 16, P: 1-13
Atmospheric P CO₂ changes recorded in lake sediments

D. Lal
R. Revelle
Research22 Mar 1984
Nature

Volume: 308, P: 344-346
Synthesis of Methane from Water for Tritium Measurement

J. S. ANAND
D. LAL
Research22 Feb 1964
Nature

Volume: 201, P: 775-777
Porosity of the Mouse Placenta to Maternal Cells

MAUREEN TUFFREY
N. P. BISHUN
R. D. BARNES
Research15 Mar 1969
Nature

Volume: 221, P: 1029-1030
Measurements of atmospheric BrO_x radicals in the tropical and mid-latitude atmosphere

O. N. Singh
R. Borchers
B. H. Subbaraya
Research18 Aug 1988
Nature

Volume: 334, P: 593-595
Lake Bonney, Taylor Valley, Antarctica: a Natural Solar Energy Trap

R. A. HOARE
K. B. POPPLEWELL
A. T. WILSON
Research30 May 1964
Nature

Volume: 202, P: 886-888
Comparative connectomics of Drosophila descending and ascending neurons

Three electron microscopy datasets are combined to provide a complete connectomic description of the neural circuitry that makes up the neck connective in Drosophila, including the descending neurons, ascending neurons and sensory ascending neurons.

Tomke Stürner
Paul Brooks
Katharina Eichler
ResearchOpen Access30 Apr 2025
Nature

Volume: 643, P: 158-172
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

Moore and colleagues show that Mycobacterium tuberculosis induces miR-33 and miR-33* in macrophages to inhibit integrated pathways involved in autophagy, lysosomal function and fatty acid oxidation, and to support bacterial replication.

Mireille Ouimet
Stefan Koster
Kathryn J Moore
Research18 Apr 2016
Nature Immunology

Volume: 17, P: 677-686
Measuring metamorphic history of unequilibrated ordinary chondrites

D. W. Sears
J. N. Grossman
A. A. Mills
Research30 Oct 1980
Nature

Volume: 287, P: 791-795

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