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The interaction between single spins and mechanical motion has been demonstrated in solid-state platforms, though limited to low-frequency modes. Here, the authors realize the coupling between an electron spin in a double quantum dot and a high-frequency mechanical mode in a suspended carbon nanotube device.

Strong lasing effects similar to those in the optical regime can occur at 1.5–2.1 Å wavelengths during high-intensity XFEL-driven Kα₁ lasing of copper and manganese.

Intratumor heterogeneity (ITH) has been mainly studied at the genomic level. Here, the authors integrate multi-region proteomics of 280 tumor regions from 33 patients, exome sequencing, and imaging-based immune and stromal profiling to investigate functional spatial proteomic ITH in breast cancer and the interactions of cancer cells and the tumor microenvironment during cancer progression.

How do fluctuations alter the dynamics of phase transitions in crystal near a mechanical instability? To answer this question, here Mao et al. present a square lattice-based analytic model showing that large entropic effects can take place at nonzero temperature near the transition.

Global sea-level rise during Meltwater Pulse 1A followed sequential ice loss from the Laurentide, Eurasian and then West Antarctic ice sheets, according to a fingerprinting approach.

Polariton interferometry reveals flat-band ultrastrong coupling between phonons and surface plasmon polaritons over a large wavevector range.

Phonon engineering with anisotropic Lorentz-type dielectric oscillations enables the creation of hyperbolic asymptotic line polaritons, achieving broadband diffraction-free propagation.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Using two-photon intravital imaging, the authors show that mechanical stress in skin triggers fluid-filled “stress vesicles” in epidermal cells, altering Piezo1-dependent calcium signals to drive stem cell differentiation and protect tissue integrity.

Phonon polaritons are promising for mid-infrared photonics but only longitudinal optical phonons are directly accessed by electrical currents. Here, the authors predict and experimentally confirm hybrid longitudinal-transverse excitations. This could lead to phonon polariton-based electrically pumped mid-infrared emitters.

Lasing with multi-pass gain is achieved in a diamond-based X-ray cavity at the European XFEL, opening a path to next-generation X-ray science.

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Most space plasmas are in turbulent state and turbulence plays an essential role in transferring energy from large to small scales. Here, the authors show direct measurements of ion cyclotron damping in the Earth’s turbulent magnetosheath plasma and the resulting ion and electron energization rates.

HIV remission of more than 6 years was achieved in a patient with functional viral co-receptors after CCR5 wild-type/Δ32 allogeneic stem cell transplantation, providing evidence of other mechanisms that can be harnessed to attain long-term remission.

The order in which driver mutations of colorectal cancer occur in intestinal epithelium can determine whether clones are positively or negatively selected and can shape subsequent tumour development.

Detection of single nanoparticles or molecules often relies on the attachment of fluorescent labels. Here, the authors demonstrate trapping a single nanoparticle on a bowtie nanoantenna and monitoring via second harmonic generation from the particle.

Multiferroics can exhibit directional dichroism, which means that they can exhibit different absorption for light travelling forward and backward. Here, the authors show that in multiferroics with a strong optical magnetoelectric effect magnetically controlled one-way transparency can be realized.

Inertial confinement fusion experiments reveal a departure from the expected hydrodynamic behaviour of a plasma when the fusion reactions become the primary source of plasma heating.

Here the authors propose a scheme for observing axion topology in 3D photonic crystals. Exploiting gyromagnetism, they demonstrate topological switching of axionic channels of light, outlining a way to realize axion topology in Weyl semimetal domain walls.

Synthesizing Se-based nanocrystals with large diameters remains challenging. Here, a reactivity-controlled epitaxial growth strategy was demonstrated to synthesize nanocrystals of ZnSe, CdSe and PbSe with average diameters of 35 nm, 76 nm and 87 nm, respectively. The large ZnSe nanocrystals emitted pure blue light, which is important for display technology.

By utilizing a microstructured optical waveguide around a microsphere, an optical anlogue of the effects of gravity on the motion of light rays is demonstrated. Both far-field gravitational-lensing effects and the critical phenomenon that occurs close to the photon sphere of astrophysical objects under hydrostatic equilibrium are experimentally demonstrated.

The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.

The authors achieve a high electrocaloric effect in barium titanate ceramics with a defect dipole engineering strategy. As a result, defect dipole engineering enables BaTiO₃ to achieve an electrocaloric effect over a wide temperature range.

Useful materials must satisfy multiple objectives. The Pareto front expresses the trade-offs of competing objectives. This work uses a self-driving laboratory to map out the Pareto front for making highly conductive coatings at low temperatures.

The coherence time during which two energetic states in a semiconductor are synchronized can be very short. Here, the authors demonstrate that despite their brief coherence times, coherent control of such states can be achieved at room temperature.

Large subduction zone earthquakes like the M 9.0 Tohoku earthquake of 2011 are followed by transient surface deformation. Here, the authors show this to be caused by rapid flow taking place in the asthenosphere due to temporarily decreased viscosity because of coseismic stress.

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics and enhance central nervous system tumor subtype classification.

This work experimentally demonstrates that light-field spatial modulation can be harnessed to substantially increase the forces used to optically levitate nanoparticles in vacuum.

Researchers use pulse front curvature and temporal chirp to control the group velocity of a soft X-ray laser pump beam, resulting in improved energy extraction and reduced pulse duration.

Trans-organ analysis of gene co-expression networks in different tissues provides a unique method for uncovering long-distance regulation.

CRISPR-Cas9 technology holds the potential to treat a wide spectrum of genetic diseases. Here, the authors describe a modular platform for extracellular vesicle-based Cas9 delivery, using MS2-based RNA-binding domains and UV-cleavable linkers, suitable for various Cas9-based moieties.

The spin–orbit interaction can be used to optically generate and control terahertz electric photocurrents in metallic ferromagnetic heterostructures.

Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling within 24 hours.

Magnetoelectrics are materials where intrinsic magnetism and ferroelectricity are coupled. Here, Khomskii argues that owing to this coupling, magnetoelectrics can have magnetic textures around electrical charges with properties analogue to magnetic monopoles.