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Showing 101–150 of 183 results

Advanced filters: Author: D. van Rooij Clear advanced filters

Genome-wide association study identifies 74 loci associated with educational attainment

A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational attainment, highlights candidate genes and pathways for further study.

Aysu Okbay
Jonathan P. Beauchamp
Daniel J. Benjamin
Research11 May 2016
Nature

Volume: 533, P: 539-542
Integrated multi-omic characterization of congenital heart disease

Single-nuclear transcriptomic and proteomic analyses identify molecular characteristics shared by multiple classes of congenital heart disease, including phenotypes associated with insulin resistance.

Matthew C. Hill
Zachary A. Kadow
James F. Martin
Research22 Jun 2022
Nature

Volume: 608, P: 181-191
Small non-coding RNAs in animal development

Our understanding of the biological functions of small non-coding RNAs has been fostered by the analysis of genetic deletions of individual microRNAs (miRNAs) in mammals. These studies show that miRNAs are key regulators of animal development and are potential human disease loci.

Giovanni Stefani
Frank J. Slack
Reviews01 Mar 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 219-230
Position-specific oxidation of miR-1 encodes cardiac hypertrophy

The 8-oxoguanine modification of the microRNA miR-1 results in redirected recognition and silencing of target genes and leads to cardiac hypertrophy in mice.

Heeyoung Seok
Haejeong Lee
Sung Wook Chi
Research05 Aug 2020
Nature

Volume: 584, P: 279-285
Successful treatment of post-traumatic stress disorder reverses DNA methylation marks

Christiaan H. Vinkers
Elbert Geuze
Marco P. Boks
Research23 Oct 2019
Molecular Psychiatry

Volume: 26, P: 1264-1271
DNA methylation signatures of educational attainment

Jenny van Dongen
Marc Jan Bonder
Bastiaan T. Heijmans
ResearchOpen Access23 Mar 2018
npj Science of Learning

Volume: 3, P: 1-14
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Jenny van Dongen
Fiona A. Hagenbeek
Dorret I. Boomsma
ResearchOpen Access08 Jan 2021
Molecular Psychiatry

Volume: 26, P: 2148-2162
Photodynamic diagnosis of breast tumours after oral application of aminolevulinic acid

D P Ladner
R A Steiner
H Walt
ResearchOpen Access03 Jan 2001
British Journal of Cancer

Volume: 84, P: 33-37
Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer

Q.-F. Yang
T. Sakurai
K. Kakudo
Research01 Nov 2000
Journal of Human Genetics

Volume: 45, P: 363-366
Variability of urinary concentrations of polycyclic aromatic hydrocarbon metabolite in general population and comparison of spot, first-morning, and 24-h void sampling

Zheng Li
Lovisa C Romanoff
Andreas Sjödin
Research26 Aug 2009
Journal of Exposure Science & Environmental Epidemiology

Volume: 20, P: 526-535
A linear mixed-model approach to study multivariate gene–environment interactions

StructLMM is a new method to identify genotype–environment interactions (G×E) that involve multiple exposures or environments. When applied to UK Biobank and eQTL data, StructLMM discovers new G×E signals.

Rachel Moore
Francesco Paolo Casale
Oliver Stegle
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 180-186
Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Willem B. Bruin
Luke Taylor
Guido A. van Wingen
ResearchOpen Access08 Oct 2020
Translational Psychiatry

Volume: 10, P: 1-12
Author Correction: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema
Daan van Rooij
Clyde Francks
Amendments and CorrectionsOpen Access08 Dec 2021
Nature Communications

Volume: 12, P: 1
A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Klaasjan G. Ouwens
Rick Jansen
Dorret I. Boomsma
Research26 Sept 2019
European Journal of Human Genetics

Volume: 28, P: 253-263
Individual prediction of psychotherapy outcome in posttraumatic stress disorder using neuroimaging data

Paul Zhutovsky
Rajat M. Thomas
Elbert Geuze
ResearchOpen Access02 Dec 2019
Translational Psychiatry

Volume: 9, P: 1-10
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra
Rainer Malik
Stephanie Debette
Amendments and CorrectionsOpen Access14 Nov 2022
Nature

Volume: 612, P: E7
High-throughput methods to help understand heart disease

Recent developments in high-throughput, in-depth sequencing platforms are providing opportunities to improve our understanding of biology and disease. Here, Kuppe et al. use a combinatorial approach to relate transcriptional changes to translational and functional implications for the heart in response to myocardial infarction.

Martijn Wehrens
Louk T. Timmer
Eva van Rooij
News & Views29 Aug 2022
Nature Cardiovascular Research

Volume: 1, P: 798-799
Sensitivity, specificity and predictive values of breast imaging in the detection of cancer

LEM Duijm
GL Guit
D Willebrand
Research01 Aug 1997
British Journal of Cancer

Volume: 76, P: 377-381
Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia

Chaja F. Jacobs
Fleur S. Peters
Helga Simon-Molas
ResearchOpen Access04 Mar 2025
Cellular & Molecular Immunology

Volume: 22, P: 485-500
Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system

Z Culig
J Hoffmann
H Klocker
ResearchOpen Access27 Aug 1999
British Journal of Cancer

Volume: 81, P: 242-251
The gut microbiota during tamoxifen therapy in patients with breast cancer

Lars E. Hillege
David J. M. Barnett
Marjolein L. Smidt
ResearchOpen Access06 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.

Rianne E. van Outersterp
Sam J. Moons
Jonathan Martens
ResearchOpen Access19 Mar 2021
Communications Biology

Volume: 4, P: 1-8
The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

Tim R. Eijgenraam
Bastiaan J. Boukens
Rudolf A. de Boer
ResearchOpen Access17 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Tumor organoid–T-cell coculture systems

Tumor-reactive T cells are generated by coculturing tumor organoids and autologous peripheral blood lymphocytes and are evaluated for their capacity to carry out effector functions after recognition of tumor cells and whether they kill tumor organoids.

Chiara M. Cattaneo
Krijn K. Dijkstra
Emile E. Voest
Protocols18 Dec 2019
Nature Protocols

Volume: 15, P: 15-39
Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Ashley A. Huggins
C. Lexi Baird
Rajendra Morey
ResearchOpen Access10 Jan 2024
Molecular Psychiatry

Volume: 29, P: 611-623
Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions

Lianne M. Reus
Iris E. Jansen
Sven J. van der Lee
ResearchOpen Access02 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-8
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma

Sanne A. M. van Lith
Anna C. Navis
William P. J. Leenders
ResearchOpen Access27 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium

Bette Loef
Jolanda M. A. Boer
Saskia W. van den Berg
ResearchOpen Access31 Oct 2024
International Journal of Obesity

Volume: 49, P: 586-595
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

Emily L. Dennis
Seth G. Disner
Rajendra A. Morey
Research19 Dec 2019
Molecular Psychiatry

Volume: 26, P: 4315-4330
Antiviral treatment following penetrating keratoplasty for herpetic keratitis

J F B Goodfellow
S Nabili
D M Tole
Research28 Jan 2011
Eye

Volume: 25, P: 470-474
Towards predicting posttraumatic stress symptom severity using portable EEG-derived biomarkers

Ashritha Peddi
Mohammad S. E. Sendi
Sanne J. H. van Rooij
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis

Charlotte W. Ockeloen
Kriti D. Khandelwal
Carine E. L. Carels
Research10 Mar 2016
Genetics in Medicine

Volume: 18, P: 1158-1162
Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era

G. Emerens Wensink
Marloes A. G. Elferink
Miriam Koopman
ResearchOpen Access13 Oct 2020
British Journal of Cancer

Volume: 124, P: 399-406
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

MicroRNAs delivered by adeno-associated viral vectors improve global and regional contractility, increase muscle mass and reduce scar size in a porcine model of myocardial infarction.

Khatia Gabisonia
Giulia Prosdocimo
Mauro Giacca
Research08 May 2019
Nature

Volume: 569, P: 418-422
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Thijs Koorman
Karin A. Jansen
Patrick W. B. Derksen
ResearchOpen Access15 Mar 2022
Oncogene

Volume: 41, P: 2458-2469
G Protein regulation of MAPK networks

Z G Goldsmith
D N Dhanasekaran
Reviews14 May 2007
Oncogene

Volume: 26, P: 3122-3142
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis

Xin Wang
Hong Xie
Israel Liberzon
Research07 Dec 2020
Molecular Psychiatry

Volume: 26, P: 4331-4343
Author Correction: The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

Tim R. Eijgenraam
Bastiaan J. Boukens
Rudolf A. de Boer
Amendments and CorrectionsOpen Access02 Oct 2020
Scientific Reports

Volume: 10, P: 1
Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders

Nevena V. Radonjić
Jonathan L. Hess
Stephen V. Faraone
ResearchOpen Access17 Jan 2021
Molecular Psychiatry

Volume: 26, P: 2101-2110
Deletions and loss-of-function variants in TP63 associated with orofacial clefting

Kriti D. Khandelwal
Marie-José H. van den Boogaard
Hans van Bokhoven
Research08 Mar 2019
European Journal of Human Genetics

Volume: 27, P: 1101-1112
Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

Individuals across six major psychiatric conditions from the ENIGMA consortium reveals a shared morphological effect, following a sensory-fugal axis, which is related to microstructural gradient and neurotransmitter axes.

Bo-yong Park
Valeria Kebets
Boris C. Bernhardt
ResearchOpen Access27 Sept 2022
Communications Biology

Volume: 5, P: 1-14
Whole genome sequencing and in vitro splice assays reveal genetic causes for inherited retinal diseases

Zeinab Fadaie
Laura Whelan
Susanne Roosing
ResearchOpen Access18 Nov 2021
npj Genomic Medicine

Volume: 6, P: 1-11
DNA methylation in peripheral tissues and left-handedness

Veronika V. Odintsova
Matthew Suderman
Jenny van Dongen
ResearchOpen Access04 Apr 2022
Scientific Reports

Volume: 12, P: 1-16
Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes

Bahram Sanjabi
Monireh Dashty
Farhad Rezaee
ResearchOpen Access06 Mar 2015
Scientific Reports

Volume: 5, P: 1-12
The dystrophin gene and cognitive function in the general population

Dina Vojinovic
Hieab HH Adams
Najaf Amin
Research17 Sept 2014
European Journal of Human Genetics

Volume: 23, P: 837-843
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

Tim Koopmans
Henriette van Beijnum
Kerstin Bartscherer
ResearchOpen Access17 Nov 2021
npj Regenerative Medicine

Volume: 6, P: 1-16
Skewed X-inactivation is common in the general female population

Ekaterina Shvetsova
Alina Sofronova
C Wijmenga
ResearchOpen Access14 Dec 2018
European Journal of Human Genetics

Volume: 27, P: 455-465
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

S. Fleur W. Meddens
Ronald de Vlaming
Philipp D. Koellinger
ResearchOpen Access11 May 2020
Molecular Psychiatry

Volume: 26, P: 2056-2069
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration

Y Wu
M S Siadaty
D Theodorescu
Research25 Aug 2008
Oncogene

Volume: 27, P: 6679-6689
Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium

Zhiqiang Sha
Daan van Rooij
Clyde Francks
ResearchOpen Access08 Feb 2022
Molecular Psychiatry

Volume: 27, P: 2114-2125

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