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Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Actuation of shape-shifting materials has typically required an external trigger. Here, the authors design a shape-memory hydrogel, regulated by a dual network of covalent and temporary hydrogen bonds, whose actuations are encoded by an intrinsic temporal mechanism.

Direct methanol fuel cells offer high energy densities but face challenges including catalyst degradation and surface fouling, which reduce performance over time. Here the authors introduce a control system inspired by reinforcement learning to optimize the power output and mitigate degradation of direct methanol fuel cells by dynamically adjusting the voltage.

Thermal excitations are typically detrimental to quantum coherence. Here, using inelastic neutron scattering measurements, the authors observe a sharp spinon spectrum in the spin-1/2 chain compound YbAlO₃ at temperatures well above the energy scale of spin interactions, indicating long-range quantum coherence.

Proteomic analysis of paired cerebrospinal fluid and plasma samples from 2,171 individuals drawn from multiple cohorts, including the Global Neurodegeneration Proteomics Consortium, reveals age-related changes in the ratios of proteins in the cerebrospinal fluid and plasma that are associated with cognitive function, enhancing understanding of blood–brain barrier dynamics in aging.

Scalable networks for processing and distribution of quantum information using photons can be achieved by using multiplexed quantum states. Here, the authors report frequency-multimode storage and spectral-temporal photon manipulation of heralded single photons at telecom wavelength, in a fully integrated setting.

Electrochemical devices producing oxygen in space face limited buoyancy, hindering gas bubble removal and increasing reaction overpotentials. Now, it has been shown that commercial magnets can enhance the reaction efficiency and induce phase separation in microgravity. The optimized magnetoelectrochemical architectures developed here may guide the designs of future life-support systems.

Genomes of nine brown algal species with different sex determination systems show that U/V sex chromosomes evolved 450–224 Ma and show remarkable conservation of genes within the sex-determining region despite independent expansions of the sex locus in each lineage.

Monoclonal antibodies targeting the conserved neuraminidase catalytic site mimic sialic acid and use coordinated water molecules to inhibit diverse influenza A and B viruses, including H5N1, providing broad prophylactic protection in mice.

Unintended and undesirable consequences can hinder policymaking. This Perspective explores how anticipatory governance can reduce ignorance, manage errors and avoid imperious immediacy when shaping future technological innovation to support more sustainable food systems transformations.

Hosseinzadeh et al. demonstrate use of a publicly accessible automated machine learning platform to differentiate between a common benign tumor and malignant transformation of it within the paranasal sinuses. This AI algorithm beat prior human prediction, and showed that physicians with no coding background can effectively utilize this tool.

Dinoflagellates and cyanobacteria produce saxitoxin (STX) congeners that block voltage-gated sodium channels. Here authors show how amphibians may sequester STX congeners using a ‘lock and key’ mode, expanding the understanding of toxic sponge action.

Johannes Krause et al. synthesized seagrass carbon stock data from 2700+ soil cores to find that they vary by plant functional group and coastal setting, indicating where conservation efforts would most effectively avoid emissions from seagrass loss

Offshore wind and wave energy may play a key role in the energy transition. Here, authors identify cost targets for these technologies to become cost effective and show how the grid’s installed capacity decreases, and generation and transmission change as offshore energy deployment increase.

Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy to target tumour metabolism indirectly.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

The authors link water and electricity system models to evaluate how the electric grid can both adapt to climate change impacts and decarbonize, while also accounting for dependencies and climate vulnerabilities of the closely coupled water sector.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits, suggesting new therapeutic prospects for various brain diseases.

A hafnium oxide memristor crossbar array integrated with transistors can provide a provable key destruction scheme in which unique physical fingerprints are extracted by comparing the conductance of neighbouring memristors, and can only be revealed if a digital key stored on the same array is erased.

The implications of delaying carbon dioxide removal (CDR) are poorly understood. Here the authors highlight the potential extra costs and reduced removal potential of delayed CDR action, with a special focus on direct air capture and bioenergy with carbon capture and storage (DACCS and BECCS).

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) that use phosphorylation in their reaction mechanisms.

The mutual neutralization of hydronium and hydroxide ions is a reaction of fundamental interest that has recently been implicated in the generation of high concentrations of hydroxyl radicals at the surface of water microdroplets. Using three-dimensional imaging of the coincident neutral products of the reaction of D₃O⁺ and OD⁻, two competing pathways for OH radical formation have now been experimentally observed.

Mesocosm experiments revealed that both phytoplankton community composition and cellular acclimation influence marine particulate C:N:P ratios, with community shifts more sensitive to nitrogen supply and acclimation to the nutrient N:P supply ratio

Chromogranin A (CgA) ablation in Tauopathy mice reduces toxic Tau buildup, reverses cognitive decline and improves lifespan. Mechanistically, the deletion of CgA normalizes the adrenergic signaling axis in the brain.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Optimized SORT LNPs enable precise and long-lasting base editing in dual organs in a disease mouse model.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

The use of electric fields to control the magnetization of ferromagnetic materials could enable more efficient electronics. Lei et al.show that by applying lateral strain to a magnetostrictive nanowire with a piezoelectric, voltage-controlled gating of magnetic domain wall motion in the wire can be achieved.

Microglia mediate the early and selective degeneration of corticostriatal synapses and the development of cognitive deficits in presymptomatic Huntington’s disease via the complement cascade.

Integrated plasmonic sources are crucial in the development of plasmonic circuitry. Here, McPolin et al. show that vertical-cavity surface-emitting lasers can be employed as an on-chip, electrically pumped source or detector of plasmonic signals and also demonstrate waveguiding and frequency conversion on this platform.

Automated iterative small-molecule synthesis has generally been limited to around one carbon–carbon bond-forming step per day. Now, a next-generation automated synthesizer enables rapid, automated, iterative synthesis of a variety of small molecules. Improvements to chemistry and automation leads to a tenfold decrease in reaction time over previous automated platforms.

Here the authors use tensile strain imposed by artificial substrates of LaLuO3 to stabilize a pure antiferroelectric phase in epitaxial thin films of PbZrO3.

Photonic quantum memories are essential to develop quantum information networks based on light. Jin et al.employ thulium-doped lithium niobate waveguides and show their suitability as memories using weak coherent pulses for two-photon interference and Bell-state measurements.

In Australia, a rapid shift to near-zero emissions electricity is key to reducing emissions and abatement costs, and from 2030 onwards, direct air capture and bioenergy with carbon capture and storage become critical options, according to an analysis that uses an integrated energy-economic model.

High-content protein arrays were used to identify cysteine dioxygenase (CDO1) as a small-molecule glue target for the von Hippel–Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal degradation of CDO1 in cells.

MetaSTAAR enables functionally informed rare variant association analysis in biobank-scale cohorts using an efficient, sparse matrix approach for summary statistic storage.

Single-stranded RNA is enzymatically synthesized without use of a template strand.

The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.

Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to generate distinct subtypes of orthotopic genetically engineered mouse models of sarcoma, as well as syngeneic allograft models with scalability for preclinical assessment of therapeutics.

Clarke et al. identify chromatin factor ZNF280A, which is recruited to damaged chromatin where it promotes long-range DNA-end resection. Loss of ZNF280A is linked to genome instability in patients with 22q11.2 distal deletion syndrome.

A comprehensive evaluation of memorization across datasets, including training samples and patient data copies, shows that latent diffusion models can memorize a diverse set of medical images with varying properties.

The consequences of postprandial IL-1β surges in white adipose tissue are unknown. Here the authors show IL-1β regulates WAT remodelling by promoting adipogenesis and energy storage, which is blocked by chronic elevation of this cytokine (as in obesity).