Nature Search

Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set

Plasma proteomics plays a key role in advancing clinical research and biomarker discovery. Here, the authors show in a large MSCoreSys multicenter benchmark study that DIA outperforms DDA, delivering robust, precise, and reproducible label-free protein quantification across sites.

Ute Distler
Han Byul Yoo
Stefan Tenzer
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1⁺ macrophage activation

Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify cellular and molecular changes in the muscle microenvironment during PAD, focusing on endothelial cell–macrophage interactions.

Guillermo Turiel
Thibaut Desgeorges
Katrien De Bock
ResearchOpen Access15 Sept 2025
Nature Cardiovascular Research

P: 1-20
Calcium transients in aequorin-injected frog cardiac muscle

David G. Allen
John R. Blinks
Research15 Jun 1978
Nature

Volume: 273, P: 509-513
Structural basis for ligand promiscuity and high signaling activity of Kaposi’s Sarcoma-associated Herpesvirus-encoded GPCR

Kaposi’s Sarcoma-associated Herpesvirus encodes ORF74, a GPCR driving oncogenesis through high basal signaling. Here, authors present cryoEM structures of both inactive and active states, revealing the structural basis for its ligand promiscuity and spontaneous activation.

Jun Bae Park
Bibekananda Sahoo
Jae U. Jung
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-18
SARS-CoV-2 infection dynamics in a MHCI-mismatched lung transplant recipient

Human transplantation with allogeneic donor organs results in non-matching of MHC and differential presentation of T cell antigens. Here the authors show that in a lung transplanted SARS-CoV-2 infected patient T cell responses generated from the host may not be able to recognise infected cells within the graft and this may contribute to virus persistence.

Jonas Fuchs
Vivien Karl
Björn C. Frye
ResearchOpen Access16 Sept 2025
Nature Communications

Volume: 16, P: 1-13
Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

Anouk Caraux
Qingxian Lu
Claude Roth
Research04 Jun 2006
Nature Immunology

Volume: 7, P: 747-754
Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions

Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity and identified potential therapeutic targets.

Brian M. Andersen
Camilo Faust Akl
Francisco J. Quintana
Research25 Jun 2025
Nature

Volume: 644, P: 1097-1106
A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

In glioblastoma (GBM), tumour microtubes (TM) connect tumour cells to a broader cellular network, with roles in tumour progression and therapy resistance. Here, the authors combine a dye uptake method in GBM xenograft models with subsequent scRNA-seq to infer a TM connectivity signature, finding CHI3L1 as a marker of connectivity.

Ling Hai
Dirk C. Hoffmann
Tobias Kessler
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-29
Dual AAV vectors for efficient delivery of large transgenes

In this Protocol, three dual adeno-associated viral strategies for delivery of large transgenes are presented—by reconstitution at the genomic, transcript or protein level—together with instructions for the design, production and evaluation of dual adeno-associated viral vectors.

David M. Mittas
Lisa M. Riedmayr
Elvir Becirovic
Protocols11 Sept 2025
Nature Protocols

P: 1-57
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences

The Candida albicans toxin, candidalysin, is embedded in an unusual conserved precursor peptide sequence (Ece1). The precursor is not required to block premature pore-forming toxicity, but rather to prevent candidalysin auto-aggregation.

Rita Müller
Annika König
Bernhard Hube
Research22 Feb 2024
Nature Microbiology

Volume: 9, P: 669-683
Localized perturbations in CheY structure monitored by NMR identify a CheA binding interface

Ronald V. Swanson
David F. Lowry
Frederick W. Dahlquist
Research01 Oct 1995
Nature Structural Biology

Volume: 2, P: 906-910
Discovery of iridoid cyclase completes the iridoid pathway in asterids

Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.

Maite Colinas
Chloée Tymen
Sarah E. O’Connor
ResearchOpen Access03 Oct 2025
Nature Plants

P: 1-13
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
The Parkinson’s disease drug entacapone disrupts gut microbiome homeostasis via iron sequestration

Entacapone, a Parkinson’s disease medication, sequesters iron resulting in a selective inhibition of gut microbial activity.

Fátima C. Pereira
Xiaowei Ge
Michael Wagner
ResearchOpen Access21 Nov 2024
Nature Microbiology

Volume: 9, P: 3165-3183
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes

Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure balance, and how deviations emerge during pathophysiological states like senescence.

Abin Biswas
Omar Muñoz
Simone Reber
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Pathology-oriented multiplexing enables integrative disease mapping

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

Malte Kuehl
Yusuke Okabayashi
Victor G. Puelles
ResearchOpen Access18 Jul 2025
Nature

Volume: 644, P: 516-526
Cryo-EM reveals an extrahelical allosteric binding site at the M₅ mAChR

The M₅ muscarinic acetylcholine receptor represents a promising therapeutic target for neurological disorders. Here, the authors reveal a 2.1 Å cryo-EM structure of the M₅ bound to a selective positive allosteric modulator site that enables structure-based drug design.

Wessel A. C. Burger
Jesse I. Mobbs
David M. Thal
ResearchOpen Access31 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Structures and mechanism of the AUX/LAX transporters involved in auxin import

This study reveals the structural basis of auxin import by the AUX/LAX family. LAX3 binds auxin as well as herbicides via a proton-coupled mechanism, which offers insights into hormone recognition that is essential for lateral root growth.

Kien Lam Ung
Lukas Schulz
Bjørn Panyella Pedersen
ResearchOpen Access04 Aug 2025
Nature Plants

Volume: 11, P: 1670-1680
Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane

IRA D. GOLDFINE
RICCARDO VIGNERI
C. RONALD KAHN
Research20 Oct 1977
Nature

Volume: 269, P: 698-700
Room-temperature cavity exciton-polariton condensation in perovskite quantum dots

Colloidal perovskite quantum dots hold promise for polaritonic devices with strong excitonic confinement. Here the authors report the observation of room-temperature cavity exciton-polariton condensation in a perovskite-based quantum dot solid, opening the door towards quantum and photonics applications.

Ioannis Georgakilas
David Tiede
Thilo Stöferle
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-8
Mast cells link immune sensing to antigen-avoidance behaviour

Mast cells are shown to function as sensor cells linking antigen recognition in type 2 immunity to antigen-specific avoidance behaviour, preventing immune activation and inflammation.

Thomas Plum
Rebecca Binzberger
Hans-Reimer Rodewald
ResearchOpen Access12 Jul 2023
Nature

Volume: 620, P: 634-642
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity

A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

Camilo Faust Akl
Brian M. Andersen
Francisco J. Quintana
Research21 May 2025
Nature

Volume: 643, P: 219-229
Insulin-like growth factor II receptor as a multifunctional binding protein

David O. Morgan
Jeffrey C. Edman
William J. Rutter
Research24 Sept 1987
Nature

Volume: 329, P: 301-307
Endogenous fungal endophthalmitis: international, multicentre, retrospective analysis of clinical outcomes following surgical and medical management, and screening

Amr Wassef
Mark P. Breazzano
Bhaskar Gupta
Research07 Oct 2025
Eye

P: 1-8
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

Christiane Rayssiguier
David S. Thaler
Miroslav Radman
Research01 Nov 1989
Nature

Volume: 342, P: 396-401
Protein translation rate determines neocortical neuron fate

Here the authors demonstrate how protein translation, controlled by Ire1α, regulates neuronal diversification in the developing neocortex.

Ekaterina Borisova
Andrew G. Newman
Mateusz C. Ambrozkiewicz
ResearchOpen Access07 Jun 2024
Nature Communications

Volume: 15, P: 1-25
Developmental Aspects of Maleic Acid-induced Inhibition of Sugar and Amino Acid Transport in the Rat Renal Tubule

Karl S Roth
David R Goldmann
Stanton Segal
Research01 Dec 1978
Pediatric Research

Volume: 12, P: 1121-1126
Inhibition of high-affinity choline transport in peripheral cholinergic endings by presynaptic snake venom neurotoxins

MIKE J. DOWDALL
JAN P. FOHLMAN
DAVID EAKER
Research20 Oct 1977
Nature

Volume: 269, P: 700-702
Thalamocortical feedback selectively controls pyramidal neuron excitability

How higher-order thalamic feedback modulates sensory-evoked cortical activity is not fully understood. This study reveals that synaptic feedback from the thalamus selectively increases the excitability of distinct cortical neurons through NMDARs and mGluR-mediated modulation of potassium channels, thereby enhancing sensory processing.

Federico Brandalise
Ronan Chéreau
Anthony Holtmaat
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-20
The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis

Wilf Gardner
David H. Sarrazin
Tsvetan Serchov
ResearchOpen Access29 Sept 2025
Molecular Psychiatry

P: 1-16
In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

Tina Drobnič
Eli J. Cohen
Morgan Beeby
ResearchOpen Access01 Jul 2025
Nature Microbiology

Volume: 10, P: 1723-1740
Apotemnophilia - the Neurological Basis of a 'Psychological' Disorder

Paul McGeoch
David Brang
Vilayanur Ramachandran
ResearchOpen Access18 Mar 2009
Nature Precedings

P: 1
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells

Aged mesenchymal stem cells exhibit decreased osteogenesis. Pouikli et al. link impaired MSC differentiation to histone hypoacetylation caused by lower mitochondrial acetyl-CoA export due to enhanced lysosomal degradation of the citrate carrier Slc25a1. Restoring histone acetylation to youthful levels rescues osteogenesis.

Andromachi Pouikli
Swati Parekh
Peter Tessarz
ResearchOpen Access13 Sept 2021
Nature Aging

Volume: 1, P: 810-825
West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems

The West African–South American lineage of Vibrio cholerae contains multiple distinct anti-phage defence systems that provide resistance to various phage families, including vibriophage ICP1, a key predator of pandemic strains.

David W. Adams
Milena Jaskólska
Melanie Blokesch
ResearchOpen Access22 May 2025
Nature Microbiology

Volume: 10, P: 1352-1365
Obesity drives depot-specific vascular remodeling in male white adipose tissue

Obesity leads to pathological expansion of white adipose tissue driving vascular dysfunction. Here, the authors utilize single-cell RNA sequencing to elucidate endothelial heterogeneity and demarcate key differences in obesity-associated vascular alterations in subcutaneous and visceral white adipose tissue.

Sana S. Hasan
David John
Andreas Fischer
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-16
Correction: The FCγ receptor of natural killer cells is a phospholipid-linked membrane protein

David Simmons
Brian Seed
Amendments and Corrections24 Aug 1989
Nature

Volume: 340, P: 662
Supernovae, grains and the formation of the Solar System

James M. Lattimer
David N. Schramm
Lawrence Grossman
Research01 Sept 1977
Nature

Volume: 269, P: 116-118
Initiation of V(D)J recombination in vitro obeying the 12/23 rule

Quinn M. Eastman
Thomas M. J. Leu
David G. Schatz
Research07 Mar 1996
Nature

Volume: 380, P: 85-88
A generic non-invasive neuromotor interface for human-computer interaction

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Patrick Kaifosh
Thomas R. Reardon
Danny Zlobinsky
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 702-711
Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines

Hillary Danz
Allison Dauner
Frank DeRosa
ResearchOpen Access29 Sept 2025
npj Vaccines

Volume: 10, P: 1-13
Single-step discovery of high-affinity RNA ligands by UltraSelex

A method called UltraSelex for identifying RNA aptamers has been developed. UltraSelex is noniterative and can combine biochemical partitioning, high-throughput sequencing and computational signal-to-background rank modeling of hits in approximately 1 day.

Yaqing Zhang
Yuan Jiang
Andres Jäschke
Research31 Mar 2025
Nature Chemical Biology

Volume: 21, P: 1118-1126
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ

Kiourtis et al. show that liver senescence triggers senescence and dysfunction in other organs through TGFβ secretion from the liver.

Christos Kiourtis
Maria Terradas-Terradas
Thomas G. Bird
ResearchOpen Access13 Nov 2024
Nature Cell Biology

Volume: 26, P: 2075-2083
The Stoichiometric Relationship between Amino-Acid and Nucleotide Residues in a Ribonucleoprotein

ERWIN CHARGAFF
DAVID ELSON
HAROLD T. SHIGEURA
Research29 Sept 1956
Nature

Volume: 178, P: 682-684
A role for clathrin light chains in the recognition of clathrin cages by ‘uncoating ATPase’

Sandra L. Schmid
William A. Braell
James E. Rothman
Research20 Sept 1984
Nature

Volume: 311, P: 228-231
Increased sensitivity of lymphocyte Δ¹pyrroline-5-carboxylate reductase to inhibition by proline with transformation

DAVID VALLE
R. MICHAEL BLAESE
JAMES M. PHANG
Research01 Jan 1975
Nature

Volume: 253, P: 214-216
Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

Fibro-adipogenic progenitors (FAPs) form part of interstitial muscle connective tissue (MCT) in adults but the origin of this non-myogenic lineage is unclear. Here, the authors show that Odd skipped related 1 (Osr1) in mice marks embryonic MCT, giving rise to FAPs, and loss of Osr1 in the limb causes muscle defects.

Pedro Vallecillo-García
Mickael Orgeur
Sigmar Stricker
ResearchOpen Access31 Oct 2017
Nature Communications

Volume: 8, P: 1-18
Mechanism of Chromosome Pairing during Meiosis

DAVID E. COMINGS
TADASHI A. OKADA
Research01 Aug 1970
Nature

Volume: 227, P: 451-456
The guanosine binding site of the Tetrahymena ribozyme

François Michel
Maya Hanna
Jack W. Szostak
Research01 Nov 1989
Nature

Volume: 342, P: 391-395
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution to psoriasis may be fueled by NET-associated RNA.

Franziska Herster
Zsofia Bittner
Alexander N. R. Weber
ResearchOpen Access08 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation

David C. LaPorte
Daniel E. Koshland Jr
Research22 Sept 1983
Nature

Volume: 305, P: 286-290

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