Nature Search

The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes

Viruses such as coxsackievirus B (CVB) have been associated with type I diabetes (T1D) and islet destruction. Here the authors show that Yes-associated protein (YAP) is upregulated in the whole pancreas in T1D and at-risk autoantibody (AAb + ) organ donors and that YAP over-expression enhances CVB replication, islet inflammation and β-cell apoptosis and suggest exocrine-islet-immune interactions as targeted interventions for T1D.

Shirin Geravandi
Huan Liu
Amin Ardestani
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-26
Sex-stratified genome-wide association meta-analysis of major depressive disorder

Sex differences are well established in the prevalence and symptoms of depression. Here, the authors identify a novel X chromosome variant, greater genetic risk, and stronger links to metabolic traits in females, highlighting the importance of sex-aware approaches.

Jodi T. Thomas
Jackson G. Thorp
Brittany L. Mitchell
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-15
The genetic contributions of individual males and females in dioecious and gynodioecious angiosperms

David G Lloyd
Research01 Feb 1974
Heredity

Volume: 32, P: 45-51
Quantum computing for faster enzyme discovery and engineering

Quantum computing is a promising technology to solve complex challenges that would take classical computers an impractical amount of time. This Perspective discusses the current state of quantum computing and possible applications in enzyme engineering and biocatalysis.

Jiri Damborsky
Petr Kouba
Stanislav Mazurenko
Reviews24 Sept 2025
Nature Catalysis

Volume: 8, P: 872-880
Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 Å resolution

David Hargreaves
David W. Rice
John B. Rafferty
Research01 Jun 1998
Nature Structural Biology

Volume: 5, P: 441-446
Control of grip and stick in cell adhesion through lateral relationships of membrane glycoproteins

David A. Rees
Clive W. Lloyd
David Thom
Research12 May 1977
Nature

Volume: 267, P: 124-128
Effect of Crohn's Disease Risk Alleles on Enteric Microbiota Marker Paper

Norman Pace
Lloyd Mayer
Charles Robertson
ResearchOpen Access12 Oct 2010
Nature Precedings

P: 1
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

Patrick W. Gray
Bharat B. Aggarwal
Glenn E. Nedwin
Research20 Dec 1984
Nature

Volume: 312, P: 721-724
Obligate anaerobe or not?

David Lloyd
Research09 May 1996
Nature

Volume: 381, P: 121
Theoretical sex ratios of dioecious and gynodioecious angiosperms

David G Lloyd
Research01 Feb 1974
Heredity

Volume: 32, P: 11-34
Female-predominant sex ratios in angiosperms

David G Lloyd
Research01 Feb 1974
Heredity

Volume: 32, P: 35-44
A consensus guide to preclinical indirect calorimetry experiments

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Alexander S. Banks
David B. Allison
Juleen R. Zierath
Reviews24 Sept 2025
Nature Metabolism

Volume: 7, P: 1765-1780
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions

A retrospective, observational study shows that completion of a diabetes prevention program in England (the NHS Diabetes Prevention Programme) was associated with decreased incidence of type 2 diabetes and long-term conditions such as dementia and chronic obstructive pulmonary disease at 24 months.

Emma Barron
Paul Chappell
Jonathan Valabhji
ResearchOpen Access10 Sept 2025
Nature Medicine

P: 1-7
Normal differentiation patterns in plants lacking microtubular preprophase bands

Jan Traas
Catherine Bellini
Michel Caboche
Research22 Jun 1995
Nature

Volume: 375, P: 676-677
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Response of Cholinergically Innervated Sweat Glands to Adrenaline and Noradrenaline

DAVID P. C. LLOYD
Research25 Jul 1959
Nature

Volume: 184, P: 277-278
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Sex ratios in sexually dimorphic umbelliferae

David G Lloyd
Research01 Oct 1973
Heredity

Volume: 31, P: 239-249
Lymph-node-derived stem-like but not tumor-tissue-resident CD8⁺ T cells fuel anticancer immunity

Here the authors dissect the developmental and functional relationship between tumor-responsive cytotoxic T cells in the tumor versus the tumor-draining lymph nodes (tdLNs), finding that stem-like T_PEX cells dependent on MYB in the tdLNs are required for CD8⁺ T cell tumor infiltration and ICB responses.

Sharanya K. M. Wijesinghe
Lisa Rausch
Axel Kallies
Research29 Jul 2025
Nature Immunology

Volume: 26, P: 1367-1383
Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron

Here, the authors characterize how different dietary components lead to functional alterations in the gut symbiont Bacteroides thetaiotaomicron, showing effects on the orientation of phase variable regions in humans, in vivo, and in vitro, and on modulating the bacterium´s proteome and immune-modulatory functionality.

Noa Gal-Mandelbaum
Shaqed Carasso
Naama Geva-Zatorsky
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-19
Pressure-induced Reduction of a Ferric Amphibole

ROGER G. BURNS
JOHN A. TOSSELL
DAVID J. VAUGHAN
Research03 Nov 1972
Nature

Volume: 240, P: 33-35
Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice

Monocytes participate in plaque formation, and adapt to metabolic changes to alter their functions. Here the authors show, using genetic mouse models and functional analyses, that Glut1-mediated glucose metabolism is important for regulating monocyte homeostasis and migration, but curiously has no impact on atherosclerotic plaque formation.

Alexandre Gallerand
Bastien Dolfi
Stoyan Ivanov
ResearchOpen Access19 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Implications of 10¹⁶ eV γ rays from Cyg X-3

David Eichler
W. Thomas Vestrand
Research16 Feb 1984
Nature

Volume: 307, P: 613-614
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

Using holistic and reductionist approaches, Karunakaran et al. identify a causal association between higher expression of RIPK1 (a central regulator of inflammatory cell function) and the risk of obesity. RIPK1 induces activation of proinflammatory signalling in adipose tissue, promoting the accumulation of macrophages that drive metabolic inflammation and obesity simultaneously.

Denuja Karunakaran
Adam W. Turner
Katey J. Rayner
Research28 Sept 2020
Nature Metabolism

Volume: 2, P: 1113-1125
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A genome-wide association study in ~3 million individuals identifies 3,952 independent variants associated with educational attainment. A polygenic index explains 12–16% of variance for this trait and contributes to risk prediction for ten diseases.

Aysu Okbay
Yeda Wu
Alexander I. Young
ResearchOpen Access31 Mar 2022
Nature Genetics

Volume: 54, P: 437-449
Tailoring π-conjugation and vibrational modes to steer on-surface synthesis of pentalene-bridged ladder polymers

Development of strategies for the synthesis of pi-conjugated polymers is hampered by limited solubility. Here, the authors report a synthetic protocol based on the search for specific vibrational modes through an appropriate tailoring of the p-conjugation of the precursors, in order to increase the attempt frequency of a chemical reaction.

Bruno de la Torre
Adam Matěj
David Écija
ResearchOpen Access11 Sept 2020
Nature Communications

Volume: 11, P: 1-8
The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK

Andrew Lloyd
David Price
Ruth Brown
Research01 Feb 2007
Primary Care Respiratory Journal

Volume: 16, P: 22-27
Manganese nodule growth rates determined by fossil diatom dating

David Kadko
Lloyd H. Burckle
Research23 Oct 1980
Nature

Volume: 287, P: 725-726
Paper Chromatography of Acidic Carbohydrates

DAVID A. REES
Research30 Jan 1960
Nature

Volume: 185, P: 309-310
Expression of human immune interferon cDNA in E. coli and monkey cells

Patrick W. Gray
David W. Leung
David V. Goeddel
Research11 Feb 1982
Nature

Volume: 295, P: 503-508
Emissivity of Human Skin in vivo between 2.0µ and 5.4µ measured at Normal Incidence

DAVID J. WATMOUGH
R. OLIVER
Research01 Jun 1968
Nature

Volume: 218, P: 885-886
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
Microwave-free nuclear magnetic resonance at molecular scales

Nitrogen vacancy centres can be used for nanoscale nuclear magnetic resonance detection but this typically involves strong microwave control pulses, making practical realizations difficult. Here the authors demonstrate a microwave-free spectroscopic protocol that can detect spins in external samples.

James D. A. Wood
Jean-Philippe Tetienne
Lloyd C. L. Hollenberg
ResearchOpen Access03 Jul 2017
Nature Communications

Volume: 8, P: 1-6
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
Australia is 'free to choose' economic growth and falling environmental pressures

Steve Hatfield-Dodds
Heinz Schandl
Alex Wonhas
Research28 Jul 2016
Nature

Volume: 534, P: S1-S2
Insect populations respond to fluctuating environments

David A. Jillson
Research18 Dec 1980
Nature

Volume: 288, P: 699-700
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
Exploring the nexus between hydroclimatic variability, population growth, land use land cover change, and long-term upper Nyong Basin River chemistry (Central Africa rainforest)

David Eric Komba
Gustave Raoul Nkoue Ndondo
Jean Jacques Braun
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-29
Crowding and the shape of COVID-19 epidemics

Analysis of spatial heterogeneity of crowding in China and Italy, together with COVID-19 case data, show that cities with higher crowding have longer epidemics and higher attack rates after the first epidemic wave.

Benjamin Rader
Samuel V. Scarpino
Moritz U. G. Kraemer
Research05 Oct 2020
Nature Medicine

Volume: 26, P: 1829-1834
Production of a model for Lesch–Nyhan syndrome in hypoxanthine phosphoribosyltransferase–deficient mice

Chao-Liang Wu
David W. Melton
Research01 Mar 1993
Nature Genetics

Volume: 3, P: 235-240
Selective dissolution of siliceous microfossils observed in a box core from the north-east equatorial Pacific

David Kadko
Joyce R. Blueford
John Barron
Research10 Mar 1983
Nature

Volume: 302, P: 139-141
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
Emissivity of Human Skin in the Waveband between 2µ and 6µ

DAVID J. WATMOUGH
R. OLIVER
Research10 Aug 1968
Nature

Volume: 219, P: 622-624
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Analysis of copy number alterations in 1,451 patient-derived xenografts (PDXs) and matched patient tumor samples shows strong conservation from patient tumors through late-passage PDXs and a lack of systematic copy number evolution driven by the mouse host.

Xing Yi Woo
Jessica Giordano
Emilie Vinolo
ResearchOpen Access07 Jan 2021
Nature Genetics

Volume: 53, P: 86-99
Ascorbate-enhanced Cytotoxicity of misonidazole

P. DAVID JOSEPHY
BRANKO PALCIC
LLOYD D. SKARSGARD
Research01 Jan 1978
Nature

Volume: 271, P: 370-372
Isolation and Amino-acid Sequence of β-LPH from Sheep Pituitary Glands

CHOH HAO LI
LIVIO BARNAFI
DAVID CHUNG
Research11 Dec 1965
Nature

Volume: 208, P: 1093-1094
Action of γ-Aminobutyric Acid on Cancer borealis Muscle

ROBERT S. EISENBERG
DAVID HAMILTON
Research08 Jun 1963
Nature

Volume: 198, P: 1002-1003
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

Diane Pennica
Glenn E. Nedwin
David V. Goeddel
Research20 Dec 1984
Nature

Volume: 312, P: 724-729
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Human chromosome 11 DNA sequence and analysis including novel gene identification

Todd D. Taylor
Hideki Noguchi
Yoshiyuki Sakaki
Research23 Mar 2006
Nature

Volume: 440, P: 497-500

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