Nature Search

Threshold effects in the excitation of autoionising states of argon atoms by electron impact

DAVID G. WILDEN
JOHN COMER
PETER J. HICKS
Research22 Jun 1978
Nature

Volume: 273, P: 651-653
Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma

Pulmonary large cell neuroendocrine carcinoma is an aggressive subtype of lung cancer. Here, the authors identify distinct subtypes based on genomic alterations and transcriptomic alterations.

Amin H. Nassar
Chul Kim
Anne C. Chiang
ResearchOpen Access19 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Cell type switching by DNA transposition in fission yeast

David H. Beach
Research20 Oct 1983
Nature

Volume: 305, P: 682-688
Transposition of a tandem duplication of yeast mating-type genes

James E. Haber
David T. Rogers
Research22 Apr 1982
Nature

Volume: 296, P: 768-770
Three-dimensional architecture of a polytene nucleus

David A. Agard
John W. Sedat
Research01 Apr 1983
Nature

Volume: 302, P: 676-681
Crystal structure of Rac1 bound to its effector phospholipase C-β2

Mark R Jezyk
Jason T Snyder
John Sondek
Research19 Nov 2006
Nature Structural & Molecular Biology

Volume: 13, P: 1135-1140
Design of high-affinity binders to immune modulating receptors for cancer immunotherapy

Immune receptors regulate immune responses and are key cancer immunotherapy targets. Here, the authors designed helical concave scaffolds to bind convex sites in immune receptors, creating high-affinity protein binders for TGFβRII, CTLA-4, and PD-L1. Co-crystal structures confirmed their therapeutic potential.

Wei Yang
Derrick R. Hicks
David Baker
ResearchOpen Access26 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Limited diversity of the rearranged T-cell γ gene

David M. Kranz
Haruo Saito
Susumu Tonegawa
Research28 Feb 1985
Nature

Volume: 313, P: 752-755
Experiential appreciation as a pathway to meaning in life

What do people mean when they say their lives are meaningful? Hicks and colleagues suggest that experiential appreciation, or valuing and appreciating one’s experiences, represents a unique pathway to the subjective feeling that life is meaningful.

Jinhyung Kim
Patricia Holte
Joshua A. Hicks
Research10 Feb 2022
Nature Human Behaviour

Volume: 6, P: 677-690
Absence of significant RNA-dependent DNA polymerase activity in lymphocytes from patients with Kawasaki syndrome

Marian E. Melish
Nyven J. Marchette
David D. Ho
Research19 Jan 1989
Nature

Volume: 337, P: 288-290
Expression of a human gene for interferon in yeast

Ronald A. Hitzeman
Frank E. Hagie
Benjamin D. Hall
Research29 Oct 1981
Nature

Volume: 293, P: 717-722
Isolation of chromosomal origins of replication in yeast

David Beach
Melanie Piper
Sydney Shall
Research13 Mar 1980
Nature

Volume: 284, P: 185-187
Electroluminescence in polymer films

David G. Lidzey
Donal D. C. Bradley
Paul F. Seidler
Research13 Mar 1997
Nature

Volume: 386, P: 135
Large-scale genome-wide analyses of stuttering

Genome-wide analyses in over one million self-reported cases and controls identify genetic variants associated with stuttering and find genetic correlations with autism, depression and impaired musical rhythm, supporting a potential neurological basis for stuttering.

Hannah G. Polikowsky
Alyssa C. Scartozzi
Jennifer E. Below
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1835-1847
Molecular rearrangement of mating-type genes in fission yeast

David Beach
Paul Nurse
Richard Egel
Research15 Apr 1982
Nature

Volume: 296, P: 682-683
Database pollution

DAVID R. STANFORD
JOHN T. PENNISTON
ERIC D. WIEBEN
Research02 Nov 1989
Nature

Volume: 342, P: 24
Associations of autozygosity with a broad range of human phenotypes

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

David W Clark
Yukinori Okada
James F Wilson
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-17
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

Induced pluripotent stem cells (iPSCs) hold great potential for modelling human developmental processes and diseases. Here the authors induce human iPSCs to spontaneously form fully laminated three-dimensional retinal tissue containing functional photoreceptor cells.

Xiufeng Zhong
Christian Gutierrez
M. Valeria Canto-Soler
Research10 Jun 2014
Nature Communications

Volume: 5, P: 1-14
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

Volume: 31, P: 2722-2736
Cloud Movements in the Tropics, and Cloud Classification

DAVID WILSON-BARKER
Research08 Dec 1887
Nature

Volume: 37, P: 129
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A genome-wide association study in ~3 million individuals identifies 3,952 independent variants associated with educational attainment. A polygenic index explains 12–16% of variance for this trait and contributes to risk prediction for ten diseases.

Aysu Okbay
Yeda Wu
Alexander I. Young
ResearchOpen Access31 Mar 2022
Nature Genetics

Volume: 54, P: 437-449
RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals

Charles Scafe
David Chao
Richard A. Young
Research04 Oct 1990
Nature

Volume: 347, P: 491-494
Regulation of NMDA channel function by endogenous Ca²⁺-dependent phosphatase

David N. Lieberman
Istvan Mody
Research19 May 1994
Nature

Volume: 369, P: 235-239
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

Alex M. Thomson
David C. West
David Lodge
Research07 Feb 1985
Nature

Volume: 313, P: 479-481
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

Richard J. Rebello
Atara Posner
Richard W. Tothill
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-15
No nuclear doubts for Japan

David Swinbanks
News31 Jul 1986
Nature

Volume: 322, P: 399
Biodiversity impacts of the 2019–2020 Australian megafires

Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas.

Don A. Driscoll
Kristina J. Macdonald
Ryan D. Phillips
ResearchOpen Access13 Nov 2024
Nature

Volume: 635, P: 898-905
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF^V600 melanoma

Different adaptive mechanisms have been reported to reduce the efficacy of mutant BRAF inhibition in melanoma. Here, the authors show BRAF inhibition induces the translational regulation of metabolic genes leading to acquired therapy resistance.

Lorey K. Smith
Tiffany Parmenter
Grant A. McArthur
ResearchOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1-21
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Nona Sotoodehnia and colleagues report a meta-analysis of 14 genome-wide association studies for QRS interval, an electrocardiogram measurement of cardiac ventricular conduction. They identify 22 loci associated with QRS duration.

Nona Sotoodehnia
Aaron Isaacs
Dan E Arking
Research14 Nov 2010
Nature Genetics

Volume: 42, P: 1068-1076
Long-term culture of murine erythropoietic progenitor cells in the absence of an adherent layer

Françoise Wendling
Mona M. Shreeve
Arthur A. Axelrad
Research13 Oct 1983
Nature

Volume: 305, P: 625-627
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Genome-wide association analysis in over one million individuals of European ancestry identifies 2,103 independent genetic signals (including 113 new loci) associated with blood pressure traits.

Jacob M. Keaton
Zoha Kamali
Helen R. Warren
ResearchOpen Access30 Apr 2024
Nature Genetics

Volume: 56, P: 778-791
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Mark P. Purdue
Diptavo Dutta
Stephen J. Chanock
Research26 Apr 2024
Nature Genetics

Volume: 56, P: 809-818
Name that asteroid

David Hughes
Books & Arts27 Oct 1994
Nature

Volume: 371, P: 756
How to be an astronomer

David Hughes
Books & Arts23 Mar 1995
Nature

Volume: 374, P: 318-319
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1412-1425
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

Lang Wu
Wei Shi
Wei Zheng
Research18 Jun 2018
Nature Genetics

Volume: 50, P: 968-978
Synaptic vesicle cytochemistry changes when cultured sympathetic neurones develop cholinergic interactions

MARY JOHNSON
DAVID ROSS
H. BURTON
Research01 Jul 1976
Nature

Volume: 262, P: 308-310
Boundary structures are formed by organic components of the Murchison carbonaceous chondrite

David W. Deamer
Research01 Oct 1985
Nature

Volume: 317, P: 792-794
Trans-complementable copy-number mutants of plasmid ColE1

Andrea J. Twigg
David Sherratt
Research10 Jan 1980
Nature

Volume: 283, P: 216-218
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

Ronald J. Koenig
Mitchell A. Lazar
David D. Moore
Research16 Feb 1989
Nature

Volume: 337, P: 659-661
Author Correction: Variable water input controls evolution of the Lesser Antilles volcanic arc

George F. Cooper
Colin G. Macpherson
Marjorie Wilson
Amendments and Corrections12 Aug 2020
Nature

Volume: 584, P: E36
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

Marcel den Hoed
Mark Eijgelsheim
Ruth J F Loos
Research14 Apr 2013
Nature Genetics

Volume: 45, P: 621-631
The map book

David W. Hughes
Books & Arts01 Sept 1994
Nature

Volume: 371, P: 30
On the shoulders of giants

David Hughes
Books & Arts03 Aug 1995
Nature

Volume: 376, P: 395
Astronomy on the box

David W. Hughes
Books & Arts06 Jun 1991
Nature

Volume: 351, P: 451
Xq–Yq interchange resulting in supernormal X-linked gene expression in severely retarded males with 46,XYq- karyotype

Bruce T. Lahn
Nancy Ma
David C. Page
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 243-250
Genetic insights into resting heart rate and its role in cardiovascular disease

The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

Yordi J. van de Vegte
Ruben N. Eppinga
Pim van der Harst
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-21
A specific inhibitor of the ran1⁺ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe

Maureen McLeod
David Beach
Research07 Apr 1988
Nature

Volume: 332, P: 509-514
The costs of human-induced evolution in an agricultural system

Pesticides overuse has led to evolution of resistance but the associated crop yield losses or economic costs at large scale are not known. This study estimates the annual cost of resistance in England for black-grass and calls for national-scale planning to address the problem.

Alexa Varah
Kwadjo Ahodo
Ken Norris
Research23 Dec 2019
Nature Sustainability

Volume: 3, P: 63-71

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