Nature Search

The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves

Temporal interference stimulation is thought to act via low-frequency envelope demodulation. Here, the authors demonstrate that stimulation thresholds in TIS follow the same carrier frequency dependence as direct kHz stimulation, indicating a shared biophysical mechanism.

Aleksandar Opančar
Petra Ondráčková
Eric Daniel Głowacki
ResearchOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Antibiotic development — economic, regulatory and societal challenges

In this Viewpoint article, seven experts discuss the challenges that are contributing to the decline in antibiotic drug discovery and development, and the international and national initiatives aimed at incentivizing research and the development of new antibiotics to improve the economic feasibility of antibiotic development.

Christine Årdal
Manica Balasegaram
Nithima Sumpradit
Reviews19 Nov 2019
Nature Reviews Microbiology

Volume: 18, P: 267-274
Somatic overgrowth associated with overexpression of insulin–like growth factor II

Ian M. Morison
David M. Becroft
Anthony E. Reeve
Research01 Mar 1996
Nature Medicine

Volume: 2, P: 311-316
Trajectory of frailty and association with adverse outcomes in patients with end-stage kidney disease over the first year of dialysis

Kerry-Lee Rosenberg
Aegida Neradova
Andrew Davenport
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Yuanbing Jiang
Xiaopu Zhou
Nancy Y. Ip
ResearchOpen Access15 Jul 2022
Nature Aging

Volume: 2, P: 616-634
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

In Alzheimer’s disease (AD) tau and neurodegeneration have complex regional relationships. Here, the authors show neuronal hypometabolism discordant with tau burden defines functional resilience or susceptibility to Alzheimer’s pathology via limbic/cortical axes. Susceptible groups have faster cognitive decline and evidence of non-Alzheimer’s pathologies.

Michael Tran Duong
Sandhitsu R. Das
Ilya M. Nasrallah
ResearchOpen Access21 Mar 2022
Nature Communications

Volume: 13, P: 1-15
A contact binary satellite of the asteroid (152830) Dinkinesh

Observations from the Lucy spacecraft of the small main-belt asteroid (152830) Dinkinesh reveals unexpected complexity, with a longitudinal trough and equatorial ridge, as well as the discovery of the first contact binary satellite.

Harold F. Levison
Simone Marchi
Yifan Zhao
ResearchOpen Access29 May 2024
Nature

Volume: 629, P: 1015-1020
Four distinct trajectories of tau deposition identified in Alzheimer’s disease

Systematic characterization of longitudinal tau variability in human Alzheimer’s disease using an unbiased subtyping algorithm reveals four trajectories of tau deposition with distinct clinical features.

Jacob W. Vogel
Alexandra L. Young
Oskar Hansson
Research29 Apr 2021
Nature Medicine

Volume: 27, P: 871-881
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The BIN1 SNP rs744373 is associated with higher CSF tau and phosphorylated tau levels. Here the authors show, using PET imaging, that this SNP is associated with tau accumulation in the brain as well as impaired memory in older individuals without dementia.

Nicolai Franzmeier
Anna Rubinski
Ansgar J. Furst
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Modelling collective action to change social norms around domestic violence: social dilemmas and the role of altruism

Lu Gram
Rolando Granados
David Osrin
ResearchOpen Access01 Mar 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-15
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access25 Jul 2019
Nature Communications

Volume: 10, P: 1-16
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

S. Mazzi
J. Garcia
I. Zychor
Research30 Jun 2022
Nature Physics

Volume: 18, P: 776-782
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.

Sonja I Berndt
Christine F Skibola
Susan L Slager
Research16 Jun 2013
Nature Genetics

Volume: 45, P: 868-876
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
Divertor shaping with neutral baffling as a solution to the tokamak power exhaust challenge

Power exhaust is one of the biggest challenges stopping fusion energy. This article shows experimental evidence for strategically shaping the power exhaust region as a solution to this challenge, utilising physics understanding to strike a balance between engineering complexity and power exhaust benefits, consistent with reduced models and simulations.

Kevin Verhaegh
James Harrison
V. Zamkovska
ResearchOpen Access23 May 2025
Communications Physics

Volume: 8, P: 1-15
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT)

Henry A. Zapata
Namrata Todurkar
Matthew W. Harer
Research11 Oct 2024
Journal of Perinatology

Volume: 45, P: 85-93
Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Aline Jelenkovic
Reijo Sund
Karri Silventoinen
ResearchOpen Access23 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

James Cerhan and colleagues report genome-wide association and meta-analysis studies to identify genetic susceptibility loci for diffuse large B cell lymphoma. They identify four loci that influence genetic susceptibility to this B cell malignancy.

James R Cerhan
Sonja I Berndt
Stephen J Chanock
Research28 Sept 2014
Nature Genetics

Volume: 46, P: 1233-1238
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
A genome-wide analysis of the response to inhaled β₂-agonists in chronic obstructive pulmonary disease

M Hardin
M H Cho
J Yates
Research27 Oct 2015
The Pharmacogenomics Journal

Volume: 16, P: 326-335
Disruption prediction with artificial intelligence techniques in tokamak plasmas

Tokamak plasmas are prone to sudden collapses that terminate the nuclear fusion reactions. This perspective discusses the prediction of these so-called disruptions with artificial intelligence techniques.

J. Vega
A. Murari
I. Zychor
Reviews06 Jun 2022
Nature Physics

Volume: 18, P: 741-750
The Effect of Tryptophan on Social Interaction in Everyday Life: A Placebo-Controlled Study

DS Moskowitz
Gilbert Pinard
Simon N Young
Research01 Aug 2001
Neuropsychopharmacology

Volume: 25, P: 277-289
A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

Shwu-Maan Lee
John M. Hickey
Jordan L. Plieskatt
ResearchOpen Access15 Jan 2020
Scientific Reports

Volume: 10, P: 1-14
Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions

Brian J Miller
David R Goldsmith
Reviews22 Sept 2016
Neuropsychopharmacology

Volume: 42, P: 299-317

Search

The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves

Antibiotic development — economic, regulatory and societal challenges

Somatic overgrowth associated with overexpression of insulin–like growth factor II

Trajectory of frailty and association with adverse outcomes in patients with end-stage kidney disease over the first year of dialysis

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

A contact binary satellite of the asteroid (152830) Dinkinesh

Four distinct trajectories of tau deposition identified in Alzheimer’s disease

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

Modelling collective action to change social norms around domestic violence: social dilemmas and the role of altruism

Human lifespan changes in the brain’s functional connectome

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Divertor shaping with neutral baffling as a solution to the tokamak power exhaust challenge

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT)

Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

A genome-wide analysis of the response to inhaled β₂-agonists in chronic obstructive pulmonary disease

Disruption prediction with artificial intelligence techniques in tokamak plasmas

The Effect of Tryptophan on Social Interaction in Everyday Life: A Placebo-Controlled Study

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions

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