Abstract
Preterm newborns are at risk for metabolic abnormalities due to immature cellular pathways, oxidative stress, and extrauterine adaptation. Lactate, historically considered a metabolic byproduct, plays a crucial role in energy metabolism, mitochondrial function, and neuroprotection. Ibrahim et al. proposes the use of sodium L-lactate (NaL) as an alternative to sodium chloride-based fluids in preterm newborns. Evidence suggests that lactate metabolism influences transcription factors, mitochondrial biogenesis, and neuronal energy utilization. However, questions remain regarding its safety, dosing, and long-term effects, particularly in neonates with brain asphyxia. Further studies are needed to evaluate NaL’s potential benefits in neonatal care.
Impact
L-lactate is important for energy production, especially in the brain.
Ibrahim et al. propose the use of sodium L-lactate as an alternative maintenance fluid in preterm newborns.
L-lactate cannot be considered only as a simple fluid replenishment.
L-lactate via its metabolism influences transcription factors, mitochondrial biogenesis, and neuronal energy utilization.
Further studies are needed to evaluate sodium L-lactate potential benefits and possible side effects in newborns.
