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Strong vibrational coupling has not been observed in ultra-high frequency mechanical resonators. By engineering phonon dissipation pathways, the authors increase the vibrational quality factor to allow strong coupling observations in plasmonic nanostructures, which has implications for observation and control of quantum phonon dynamics.

ARMH2 is identified as a previously unknown cytosolic component of the sperm-specific CatSper channel, critical for its normal assembly and pH/calcium sensitivity. Loss of ARMH2 impairs sperm hyperactivation and causes severe subfertility.

Cannulae are heat-resistant protein nanotubes found on the surface of thermophilic archaea. Here, the authors report the structures of cannulae at the atomic level with insight into their high stability and mechanism of assembly, which has potential impact for biomaterials design.

ABC toxins are bacterial insecticides with biotechnological potential. Here, Low et al. have deciphered soluble and membrane-inserted structures of YenTc that highlight structural and mechanistic diversity in the ABC toxin family and provide insights into their evolution.

The success of Li batteries relies on electrolyte reduction at anodes for interphase formation, yet controlled interphase formation on high-energy cathodes has proven challenging. Now it has been shown that a bimolecular nucleophilic substitution-assisted strategy advances both primary and secondary batteries by regulating the electrolyte reduction potential and interphase passivation capability.

This study defines a two-receptor entry mechanism for coxsackievirus A6: heparan sulfate for initial attachment and KRM1 for uncoating. Protective antibodies that block KRM1 binding were identified, offering a path for therapeutic development.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Metal nanocrystals are used in an ever growing list of applications, but precise control and understanding of their formation can be difficult. Here, the authors show a route that allows the controlled formation of metal nanocrystals to be carried out and observed at an atom-by-atom level.

Human antibodies DENV-290 and DENV-115 are ultrapotent against dengue virus 3 strains with differing particle morphologies. CryoEM shows both bind across two protomers at the center of the envelope protein dimer, defining a new class of epitope.

Nanocrystal assembly is key to creating complex architectures. Here, the authors show that tuning competitive ion adsorption alters anisotropic surface potentials and electrostatic torques, directing facet attachment to enable alternative mesoscale designs.

Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a mechanism that is independent of genes required for biofilm formation.

Bulk superconductivity has been observed up to 96 K in pressurized bilayer nickelate single crystals which were synthesized under ambient pressure.

Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.

Here the authors design tripeptides that form dynamic soluble dispersions and undergo phase separation upon drying to assemble into porous particles. This evaporation-driven emulsification can be harnessed to encapsulate and stabilize biomolecules.

A method combining scanning transmission electron microscopy with high-resolution electron energy-loss spectroscopy enables the observation of magnons and their dispersion, and provides a way to examine magnetic inhomogeneities with nanometre spatial resolution.

A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.

Self-assembly in nature is dynamic and exists in out-of-equilibrium state and thus systems have the ability to autonomously respond to environmental changes. Here the authors report that input of thermal energy can trigger fixed, artificial toroids to spontaneously nucleate helical growth.

A new form of momentum-selective electron energy-loss spectroscopy enables the element-resolved imaging of frequency- and symmetry-dependent vibrational anisotropies with atomic resolution.

Transparent conductive electrodes are widely used in modern optoelectronic devices, but they are rarely transparent in the near-infrared, limiting their use. Nanostructured bismuth selenide, a topological insulator, is now shown to be a flexible near-infrared transparent electrode.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Accurately describing and tuning active sites remains a major challenge. Here, the authors introduce an effective metal-ion chelation strategy—guided by DFT predictions and in situ Raman measurements—to structurally engineer and quantitatively link the electronic properties of active sites in an ionic liquid.

There are gaps in international efforts to monitor the wildlife trade, with many species potentially being undetected by the established monitoring groups. Here the authors use an automated web search to document the sale of reptiles online, revealing over 36% of all known reptile species are in trade, including many missing from official databases.

B. thuringiensis spores contain uncharacterized protein filaments that extend from the surface of the exosporium. Here, the authors show that these filaments feature conserved β-barrel neck domains and promote spore clustering through protein contacts and filament bundling, and reveal a mechanism for biofilm-like spore aggregation.

Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which increases drag and prevents sinking. The pili also enrich microcystin and co-localize with iron-enriched extracellular matrix components, suggesting a vital role in bloom proliferation.

The ability to form pores in the plasma membrane of host airway epithelial cells is a common feature of many structurally diverse allergens that induce type 2 immune responses by stimulating IL-33 release and causing Ca²⁺ influx.

A new aluminosilicate zeolite called ZMQ-1 is introduced that has an intrinsic meso-microporous channel system and shows high thermal and hydrothermal stability and tunable framework Si/Al molar ratios.

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

The human monoclonal antibody S2X259 cross-reacts with spike proteins from all clades of sarbecovirus, and provides prophylactic and therapeutic protection in vivo against parental SARS-CoV-2 and emerging variants of concern.

The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechanism.

Direct human impact on land disturbances in the USA is declining, while less controllable, undirected wild disturbances are increasing, according to a long-term record of high-resolution satellite imagery.

Structural analyses of antibody-virus complexes offer critical insights into immune recognition mechanisms. In this report, we present how a patient-derived IgG recognizes a quaternary epitope on EEEV particles through strictly bivalent interactions.

Atomically thin gratings, fabricated in single-layer graphene, can act as nanomechanical diffraction elements for high-contrast quantum interference of phthalocyanine molecules.

Electrolyte design is crucial for lithium metal battery development. Here the authors report an electrolyte with a compact solvation structure on the nanometre scale that facilitates fast interfacial reaction kinetics and improves battery performance.

Samples returned from asteroid Bennu largely comprise hydrated sheet silicates with sulfides, magnetite and carbonate that indicate alteration by a fluid that evolved from neutral to alkaline, according to a micro- and nanoscale mineralogical study.

Chiral interactions in magnetic systems enable topologically nontrivial magnetic textures, most notably topological solitons such as skyrmions. Here Volkov et al study the magneto-chiral interactions in a small asymmetric magnetic cap, and show how the geometric asymmetry influence the chiral spin- textures.

Molybdenum disulphide may be prepared by lithiation and exfoliation; however the process requires a long lithiation and produces low yields. Here, the authors show that metal naphthalenides may be used for the intercalation, and that the resulting products are of high quality and may be inkjet-printed.

The presynaptic protein Munc13 forms nanoclusters at synaptic release sites, but its internal organization is unclear. Here, the authors show that two distinct ordered Munc13 oligomers couple synaptic vesicle docking and SNARE assembly to regulate neurotransmission

Upcycling urine in wastewater for nitrogen and phosphorus production has gained attention, but their low market values hamper the application. Here, the authors develop a yeast platform that mimics osteoblast mechanisms to produce the high-value hydroxyapatite directly from urine.

Cryogenic correlated light, ion and electron microscopy (cryo-CLIEM) integrates three-dimensional confocal microscopy with focused ion beam–scanning electron microscopy for efficient preparation of lamellae containing target structures for in situ structural biology with cryo-electron tomography.

The cryo-EM structure of immature Zika virus shows partially ordered capsid proteins and reveals differences between pre-epidemic and epidemic strains at protein interfaces within the trimeric spikes.

The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key intermediates of the mHsp60-mHsp10 reaction cycle.

The frictional force required to move a liquid drop on a surface is known to depend upon the drop resting time. N'guessan et al. demonstrate that water drops on graphene surfaces are an exception, which is attributable to the chemical homogeneity and stability of graphene surfaces.