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Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Measurements of the superfluid stiffness in twisted trilayer graphene reveal unconventional nodal-gap superconductivity, where the superconducting transition is controlled by phase fluctuations rather than Cooper-pair breaking.

Holistic indicator frameworks are needed to track food systems transformation. This Analysis shows the application of a framework recently developed by the Food Systems Countdown Initiative to all UN member states, revealing current status, data gaps and priority actions.

Trilayer graphene with the layers consecutively twisted by the same angle is shown to be a platform in which correlated and topological states exist, driven by local lattice relaxations.

Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma, and they prospectively validate its prognostic value.

Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

Animal migrations are extensive and crucial for ecosystem health but are in decline. This study identifies 1,787 sites and links among them for 109 marine species, highlighting the need for international cooperation and providing policymakers with essential knowledge for effective conservation.

Research on superconductivity in magic-angle twisted bilayer graphene reveals unconventional behaviour, an anisotropic gap and a significant role of quantum geometry, using combined d.c. transport and microwave measurements, suggesting new insights into superconductivity mechanisms.

Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccine formulation.

G49, a dual glucagon/glucagon-like peptide-1 receptor agonist, triggers an inter-organ crosstalk between adipose tissue, pancreas and liver, leading to brown fat activation with the final outcomes of increased energy expenditure and body weight loss.

Online support groups for people with a chronic condition may positively impact social welleing, behaviour, and adjustment, but they may negatively influence anxiety and distress. The effects on physical health and quality of life are inconclusive.

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Body size is hypothesised to be a major determinant of β-diversity in passively-dispersing marine organisms. Here, Villarino et al. show that plankton body size determines rates of dispersal along marine currents, with shorter dispersal and higher species spatial turnover in larger organisms.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

To promote the recovery of the currently declining global trends in terrestrial biodiversity, increases in both the extent of land under conservation management and the sustainability of the global food system from farm to fork are required.

One of the possible events signaling a neutrinoless double beta decay is a Xe atom decaying into a Ba ion and two electrons. Aiming at the realisation of a detector for such a process, the authors show that Ba ions can be efficiently trapped (chelated) in vacuum by an organic molecule layer on a surface.

The 2023 monkeypox outbreak was caused by a subclade IIb monkeypox virus (MPXV). Here, using advanced sequencing techniques, the authors identify variations on low-complexity regions of the MPXV genome and describe their potential as evolutionary drivers.

Previous studies identified an association between the 2q35 locus and breast cancer. Here, the authors show that a SNP at 2q35, rs4442975, is associated with oestrogen receptor positive disease and suggest that this effect is mediated through the downregulation of a known breast cancer gene, IGFBP5.

The adsorption of OH species is of paramount importance in many electrochemical reactions of interest and, so far, it is frequently assumed that it takes place at potentials higher than 0.55 V. Here the authors demonstrate OH is adsorbed at more negative potentials on the low coordinated Pt atoms by CO displacement experiments and Raman spectroscopy.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Cell adhesion proteins have been described at sites away from the cell surface, including in the nucleus. Here, the authors report the scale of nuclear localisation of adhesion proteins, establishing a nucleo-adhesome and showing that nuclear adhesion proteins can cooperate to control transcription.

Barium tagging is a key ingredient for future detectors of neutrinoless double beta decay in low-background environments. Here, the authors demonstrate fluorescence imaging of single Ba2+ ions in high pressure Xenon gas, by comparing activity between Ba2+ chelated and unchelated samples of crown-ether chemosensors.

Kim Worley and colleagues report the whole-genome sequence of the common marmoset, Callithrix jacchus, the first New World monkey to be sequenced.

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

An on-chip platform with in situ adjustable interfacial properties, using a microelectromechanical system, provides multi-degree-of-freedom control of two-dimensional materials, including twisting and pressurizing.

Combined hepatocellular-cholangiocarcinomas (cHCC-CCA) are challenging to diagnose, as they exhibit features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA). Here, the authors use deep learning to re-classify cHCC-CCA tumours into HCC or ICCA based on histopathology images.

Ensuring that waste or by-products from one process form the input of another is key for food systems sustainability. This study assesses the biophysical potential of redesigning the European (EU27 + UK) food system on the basis of circularity principles. Changes in food consumption, crop production, animal production and fertilizer patterns are considered through scenario analysis.

In the first results from an ongoing global cancer screening data repository, screening program organization was better overall in Europe compared to other continents; however, there were substantial gaps in implementation across both high- and low-resource settings.

Superconducting single-photon detectors are critical for quantum communication, fluorescence lifetime imaging and remote sensing, but commonly operate at very low temperatures. Now, high-temperature cuprate superconducting nanowires enable single-photon detection up to 25 K.

A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

Water thermodynamics drive changes in macromolecular assembly that rapidly restore intracellular water availability in response to physiological fluctuations in temperature, pressure and osmotic strength.

Endothelial cells in white adipose tissue are shown to produce polyamines, which regulate adipocyte lipolysis, thus demonstrating how local angiocrine signals contribute to healthy adipose tissue homeostasis.

Correlations between tree species diversity and tree abundance are well established, but the direction of the relationship is unresolved. Here the authors use path models to estimate plausible causal pathways in the diversity-abundance relationship across 23 global forests regions, finding a lack of general support for a positive diversity-abundance relationship, which is prevalent in the most productive lands on Earth only

China’s feed imports have a considerable environmental impact globally. This modelling study quantifies China’s potential protein self-sufficiency by simulating farming spatial relocation according to irrigation water and nitrogen surplus, as well as technological innovations and demand-side measures.

High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.

Optical chiral induction and spontaneous gyrotropic electronic order are realized in the transition-metal chalcogenide 1T-TiSe₂ by using illumination with mid-infrared circularly polarized light and simultaneous cooling below the critical temperature.

The Chamaeleon I dense cloud was observed with JWST as part of the Early Release Science programme ‘IceAge’. Here the authors present the detection of dangling OH features at ~2.7 μm, providing a tracer of icy grain morphology.

Canon et al. offer insights into the auto-inhibition and activation of the minus-end directed motor myosin VI. The work highlights how differential relief of auto-inhibition allows for fine control of myosin VI activity in vivo.

Genetic susceptibility loci for oropharyngeal cancer have been reported but these studies have not always examined human papillomavirus (HPV) status. Here, the authors perform genome-wide analysis taking into account HPV16 serology status and report two independent loci in the HLA region, suggesting the protective role of HLA variants against HPV infection.

In a circular food system, animals are solely fed with low-opportunity biomass, resulting in substantially smaller herds and lower animal production. Using a resource-allocation model, this study examines whether the adoption of circularity in the EU-27 + UK would meet requirements of the EAT-Lancet reference diet.