Concurrent chemoradiotherapy is a highly efficacious locoregional treatment option for solid tumors. The rationale for the use of concurrent chemoradiotherapy for treating malignancies, and the molecular basis for combining classic cytotoxic agents and novel targeted therapies agents with radiotherapy are discussed. This article is part one of two articles. In the subsequent article, the general principles outlined here will be applied to head and neck cancer, where the impact of concurrent chemoradiotherapy is particularly evident.
- Tanguy Y Seiwert
- Joseph K Salama
- Everett E Vokes
