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Hydrocarbon selectivity in photoelectrochemical CO₂ reduction has been limited due to a lack of low-overpotential catalysts and high-photovoltage semiconductors. Here Cu nanoflowers are interfaced with perovskite light absorbers for bias-free conversion of CO₂ to ethane and ethylene coupled to water or glycerol oxidation.

Biomarkers of age and frailty may aid in understanding the aging process, predicting lifespan or health span and in assessing the effects of anti-aging interventions. Here, the authors show that combining physics-based models and deep learning may enhance understanding of aging from big biomedical data, observe effects of anti-aging interventions in laboratory animals, and discover signatures of longevity.

Quantum geometry and electron–phonon coupling are two fundamental concepts in condensed matter physics that govern many correlated ground states. Now a generalized theory connects these two ideas.

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

The authors develop a scalable reactive sintering method to produce ZrNiSn-based thermoelectrics without melting, achieving a high zT of 1.33 at 873 K through hierarchical microstructure engineering and detailed property analysis.

Cannulae are heat-resistant protein nanotubes found on the surface of thermophilic archaea. Here, the authors report the structures of cannulae at the atomic level with insight into their high stability and mechanism of assembly, which has potential impact for biomaterials design.

Fractional Chern insulators, and their time-reversal analogs, fractional topological insulators, are realizations of topological order in flat-band electronic systems; while the former have been realized experimentally in twisted bilayer MoTe₂, the latter have remained more elusive. Here, using exact diagonalization calculations, the authors propose routes towards engineering fractional topological insulators in twisted bilayer MoTe₂ and other moiré materials.

An engineered RNA A-to-I deaminase (rABE) offers low sequence bias, high activity and low background for REMORA (RNA-encoded molecular recording in adenosines) and enables improved molecular recording of RNA–protein interactions.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during the translocation step.

Cancer incidence is rare in long-lived bats. Here the authors find that although bat fibroblasts express telomerase and require only two oncogenic hits for malignant transformation, bats may rely on elevated p53 signaling and enhanced immunosurveillance to prevent cancer.

Researchers have demonstrated the generation and control of subfemtosecond pulse pairs from a two-colour X-ray free-electron laser and conducted pump–probe experiments in core-ionized molecules.

Injecting spin-polarized current into a ferromagnetic thin film via a nanocontact is expected to generate a radially-symmetric spin wave soliton. Here, the authors use time-resolved x-ray microscopy and micromagnetic simulations to demonstrate the occurrence of p-like symmetry associated with non-uniform magnetic fields in the nanocontact region.

The existence of a topological bulk-boundary correspondence for Dirac semimetals has remained an open question. Here, Wieder et al. predict one-dimensional hinge states originating from bulk three-dimensional Dirac points in solid-state Dirac semimetals, revealing condensed matter Dirac fermions to be higher-order topological.

The mechanism of the multiple-q charge density wave phase in the antiferromagnetic kagome metal FeGe is not fully understood. Here the authors reveal dimerization-driven hexagonal charge-diffuse precursor and identify the fraction of dimerized/undimerized states as the key order parameter of the phase transition.

Time-resolved measurements of the X-ray photoemission delay of core-level electrons using attosecond soft X-ray pulses from a free-electron laser can be used to determine the complex correlated dynamics of photoionization.

A new phylogenomic tree for butterflies is constructed using 391 genes from 2,300 species, representing 92% of genera. It suggests that butterflies originated around 100 million years ago in what is now the Americas and originally fed on Fabaceae.

A direct, selective photocatalytic method for synthesizing glycols from olefins at room temperature uses water as the oxidizing agent and H₂ as byproduct. The hydroxylation proceeds by hydroxyl radicals formed by photocatalytic dissociation of water.

EF-G drives ribosomal translocation along mRNA. Time-resolved cryo-EM captured translocation with EF-G•GTP—without inhibitors—revealing how EF-G uses ribosome fluctuations to drive translocation and GTP hydrolysis to leave at the right moment.

In chiral helimagnets, the Dzyaloshinskii–Moriya interaction is known to stabilize skyrmions, but the microscopic roots remain enigmatic. Here, Janson et al. apply a multi-scale approach to Cu₂OSeO₃and show that its skyrmions can be traced back to magnetic tetrahedra of a quantum nature.

Potential electronic applications of graphene rely on controlling its spin-dependent properties. Here, the authors use spin-resolved photoemission spectroscopy to demonstrate how Au-intercalation produces gapped one-dimensional quasi-freestanding graphene on Fe(110) with tunable Fermi surface spin texture.

A genome-wide association study meta-analysis combined with multiomics data of osteoarthritis identifies 700 effector genes as well as biological processes with a convergent involvement of multiple effector genes; 10% of these genes express the target of approved drugs.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Comparative chromosome-scale genome sequencing and transcriptomic and epigenomic profiling of three different species of annelid provide insight into the evolutionary origin of larvae.

A comparative analysis of head-regeneration capacity across planarian species in a phylogenetic context reveals multiple Wnt-dependent transitions in head-regeneration ability and proposes Wnt functions in the reproductive system as possible evolutionary drivers.

In this disease mapping study, the authors estimate disability-adjusted life year rates for three of the major causes of mortality for children under five 43 countries in sub-Saharan Africa. They identify significant heterogeneity at the subnational level, highlighting the need for a targeted intervention approach.

Digenic inheritance of deleterious variants in serine/arginine protein kinase 3 (SRPK3) and titin (TTN) leads to a progressive early onset skeletal muscle myopathy. Zebrafish double mutants exhibit a similar myopathy phenotype accompanied by myofibrillar disorganization.

An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.

A custom-designed metamaterial mask helps improve the accuracy of microscopy of single fluorescent molecules.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

2D materials have attracted significant attention for memristor applications, but a complete understanding of the switching mechanisms is still lacking. Here, the authors report an operando electron microscopy study of lateral MoS₂ memristors, showing real-time imaging of the dynamics of Ag conductive filaments during bias voltage cycles.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Here, the authors present the 3.5-Å-resolution cryo-EM structure of the jumbo phage ΦKZ capsid, revealing ten minor capsid proteins that are hypothesized to contribute to capsid assembly and stabilization.

Using a novel method for isolating cognitive and motor neural dynamics, the authors show that dynamics often attributed to cognitive processes were corrupted by movements and that distinct populations of neurons encode cognitive and motor variables.

Skatole is a bacterial metabolite responsible for boar taint and the objectionable smell of manure. Here, the authors elucidate the final step of skatole biosynthesis, describing the discovery and biochemical characterization of the enzyme catalysing the conversion of indoleacetate into skatole.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Phonon polaritons can be harnessed for SEIRA spectroscopy. Here, the authors demonstrate a compact on-chip phononic SEIRA platform based on a h-BN/graphene/h-BN heterostructure atop a metal split-gate that serves both as a SEIRA substrate and as a room-temperature infrared detector.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

Here, the authors mapped the regulatory landscape of TetR transcription factor binding sites in E. coli. This rugged landscape suggests few yet accessible high-repression peaks, offering insights into how prokaryotic regulation evolves within complex sequence spaces.

In the CheckMate 7FL trial, neoadjuvant nivolumab and chemotherapy in patients with newly diagnosed, high-risk estrogen receptor-positive breast cancer led to an increased pathological complete response rate compared with neoadjuvant chemotherapy alone, and this increase was associated with immune-related biomarkers and estrogen receptor expression.

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

Understanding the distribution of energy between electric and magnetic channels of a metamaterial remains elusive. Decker et al.study the emission of quantum dots into these channels for a split-ring-resonator metamaterial and differentiate the fundamental behaviour of the two modes.

The recently discovered charge density wave in ScV₆Sn₆ kagome metal is under intense debate. By using a combination of experimental and theoretical techniques, the authors point to the role of flat phonon mode softening and momentum-dependent electron-phonon coupling in the formation of the charge density wave.

Hyaluronic acid is believed to plays a critical role in cancer resistance and longevity of the naked mole rat. Here, Zhao and colleagues show that accumulation of high levels of hyaluronic acid has co-evolved repeatedly in mammalian clades with adaptation to subterranean habitats.

In this work, the authors present an active optical metasurface based on a silicon-organic platform. The metasurface can modulate the amplitude of a reflected beam via electric voltage actuation lower than ± 17V.

Analyses of 34 ancient genomes from northeastern Siberia, dating to between 31,000 and 600 years ago, reveal at least three major migration events in the late Pleistocene population history of the region.

Vibrational strong coupling (VSC) promises ultrasensitive IR spectroscopy and modification of material properties. Here, nanoscale mapping of VSC between organic molecules and individual IR nanoresonators is achieved by remote near-field spectroscopy.