Nature Search

Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

Jae-Hyung Jin
Kyung-Tae Lee
Yong-Sun Bahn
ResearchOpen Access24 Aug 2020
Nature Communications

Volume: 11, P: 1-17
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas

CellSpectra identifies functionally relevant changes in cellular pathways when analyzing single samples in comparison to a reference atlas, here applied to rodent models and patient samples of kidney disease.

Konstantin A. Klötzer
Amin Abedini
Katalin Susztak
Research07 Aug 2025
Nature Genetics

Volume: 57, P: 1922-1934
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

The amount of genetic material that can be packaged in AAV vectors used for genome editing is limited. Here the authors show that the smallest known Cas9 orthologue, cjCas9, can be packaged in a single AAV vector along with sgRNA and a marker gene, and demonstrate efficient gene editing in mice.

Eunji Kim
Taeyoung Koo
Jin-Soo Kim
ResearchOpen Access21 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Drosophila immune cells transport oxygen through PPO2 protein phase transition

Drosophila haemocytes collaborate with the tracheal system to reserve and transport oxygen through the phase transition of PPO2 crystals, facilitating internal oxygen homeostasis in a process that is comparable to vertebrate respiration.

Mingyu Shin
Eunji Chang
Jiwon Shim
ResearchOpen Access26 Jun 2024
Nature

Volume: 631, P: 350-359
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health

Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.

Daigoro Hirohama
João Fadista
Katalin Susztak
Research12 Aug 2025
Nature Medicine

P: 1-13
Combined effects of traffic-related air pollution, climate factors, and greenness on respiratory disease risk in infants

Ji Young Lee
Seulbi Lee
Jin Hwa Lee
ResearchOpen Access25 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Author Correction: The Ca²⁺-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Go Eun Ha
Jaekwang Lee
Eunji Cheong
Amendments and CorrectionsOpen Access05 Nov 2021
Nature Communications

Volume: 12, P: 1
Multimodal AI for risk stratification in autism spectrum disorder: integrating voice and screening tools

Sookyung Bae
Junho Hong
Keun-Ah Cheon
ResearchOpen Access21 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-15
TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors

Here, the authors have integrated genome-wide association data with functional genomics data relevant to the kidney and performed in vitro and in vivo experiments which support TET2 as a kidney disease risk gene.

Xiujie Liang
Hongbo Liu
Katalin Susztak
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

Yoonhee Jin
Jung Seung Lee
Seung-Woo Cho
Research11 Jul 2018
Nature Biomedical Engineering

Volume: 2, P: 522-539
Directed evolution of CRISPR-Cas9 to increase its specificity

Undesired off-target effects can hamper the use of CRISPR-Cas9 in therapeutic applications. Here the authors use a directed evolution approach to develop Sniper-Cas9 which combines high specificity with no loss of on-target activity.

Jungjoon K. Lee
Euihwan Jeong
Jin-Soo Kim
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-10
The Ca²⁺-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Spike-frequency adaptation in thalamocortical (TC) neurons is important for sensory transmission though the underlying mechanisms are not fully understood. Here, the authors identify a role for the calcium-activated chloride channel, ANO2, in mediating TC spiking adaptations and visceral pain response.

Go Eun Ha
Jaekwang Lee
Eunji Cheong
ResearchOpen Access19 Dec 2016
Nature Communications

Volume: 7, P: 1-13
Chromosome-level Genome Assembly of the Halophytic Turfgrass Zoysia macrostachya

Hyeonseon Park
Eunji Bae
Donghwan Shim
ResearchOpen Access31 Jul 2025
Scientific Data

Volume: 12, P: 1-9
ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer

ESRP1 is reported to regulate the alternative splicing of some genes involved in epithelial–mesenchymal transition. Here the authors show that LRRFIP2 is a target of ESRP1 and that two spliced variants of LRRFIP2 have opposing functions in gastric cancer metastasis

Jihee Lee
Kyoungwha Pang
Seong-Jin Kim
ResearchOpen Access28 Oct 2022
Nature Communications

Volume: 13, P: 1-15
Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder

Sujung Yoon
Woojin Won
In Kyoon Lyoo
ResearchOpen Access28 Jul 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-19
N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer

Rebecca Yun
Eunji Hong
Jin Muk Kang
ResearchOpen Access23 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-12
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

Ferroptosis is an iron-dependent cell death mechanism that is emerging as a target for cancer therapy. Here, the authors find that lipoprotein-associated phospholipase A2 modulates ferroptosis resistance by controlling phospholipid metabolism.

Mihee Oh
Seo Young Jang
Eun-Woo Lee
ResearchOpen Access15 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells

Kyoungwha Pang
Jihee Lee
Seong-Jin Kim
ResearchOpen Access22 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-11
A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

Low-grade systemic inflammation and stress increase vulnerability to neuropsychiatric disorders. Here, the authors show that inflammation and stress-induced changes in higher order cognitive networks increase vulnerability to posttraumatic stress disorder.

Jungyoon Kim
Sujung Yoon
In Kyoon Lyoo
ResearchOpen Access20 Apr 2020
Nature Communications

Volume: 11, P: 1-12
Effects of deep neuromuscular block with low-pressure pneumoperitoneum on respiratory mechanics and biotrauma in a steep Trendelenburg position

Ji Eun Kim
Sang Kee Min
Hyun Jeong Kwak
ResearchOpen Access21 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Barcode-free next-generation sequencing error validation for ultra-rare variant detection

Next generation sequencing has difficulty in detecting rare-frequency variants due to high sequencing errors. Here the authors present a barcode-free error validation method that physically extracts erroneous reads to identify true variants.

Huiran Yeom
Yonghee Lee
Sunghoon Kwon
ResearchOpen Access28 Feb 2019
Nature Communications

Volume: 10, P: 1-8
Efficient Sn Recovery from SnO₂ by Alkane (C_xH_y=2x+2, 0 ≤ x ≤ 4) Reduction

Hyesung An
Mi Yoo
Hyun You Kim
ResearchOpen Access13 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor

The protein levels of the tumour suppressor p53 can be negatively regulated by HDM2, which is an attractive target for cancer therapy. In this study, Lee et al. graft the transactivation domain of p53 onto a scaffold protein and show that this binds to HDM2 and inhibits cancer cell growth in vitro.

Jung-Hoon Lee
Eunji Kang
Jae Il Lee
Research07 May 2014
Nature Communications

Volume: 5, P: 1-12
Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation

Jiyeon Lee
Fumiyuki Sasaki
Lark Kyun Kim
ResearchOpen Access24 Aug 2024
Cell Death & Differentiation

Volume: 31, P: 1679-1694
Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

Hoyoung Kim
Taehyun Lim
Hyun-Soo Cho
ResearchOpen Access01 Sept 2023
Experimental & Molecular Medicine

Volume: 55, P: 2039-2050
Targeted dual base editing with Campylobacter jejuni Cas9 by single AAV-mediated delivery

Jiyeon Kweon
An-Hee Jang
Yongsub Kim
ResearchOpen Access01 Feb 2023
Experimental & Molecular Medicine

Volume: 55, P: 377-384
Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders

Junho Lee
Shin Ju Oh
Chang Kyun Lee
ResearchOpen Access29 Oct 2024
npj Genomic Medicine

Volume: 9, P: 1-11
Optimized single-step optical clearing solution for 3D volume imaging of biological structures

OptiMuS is an optical clearing method which preserves endogenous fluorescence and sample sizes and can be used to clear thick tissues, visualize neural networks and vascular structures and diagnose pathological status of kidneys, as a potential application.

Kitae Kim
Myeongsu Na
Sunghoe Chang
ResearchOpen Access09 May 2022
Communications Biology

Volume: 5, P: 1-10
Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs

Gahyang Cho
Kwangbeom Hyun
Yong-Mahn Han
ResearchOpen Access03 Jul 2023
Experimental & Molecular Medicine

Volume: 55, P: 1506-1519
Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors

Eunji Hong
Wojciech Barczak
Seong-Jin Kim
ResearchOpen Access10 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-9
Author Correction: Association between social support and postpartum depression

Hahyeon Cho
Kyeongmin Lee
Kui Son Choi
Amendments and CorrectionsOpen Access04 Mar 2022
Scientific Reports

Volume: 12, P: 1
Correction: Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

Seong-Hoon Kim
Hye Guk Ryu
Kyong-Tai Kim
Amendments and CorrectionsOpen Access29 Oct 2015
Scientific Reports

Volume: 5, P: 1
Deep learning-based diagnosis of Alzheimer’s disease using brain magnetic resonance images: an empirical study

Jun Sung Kim
Ji Won Han
Ki Woong Kim
ResearchOpen Access26 Oct 2022
Scientific Reports

Volume: 12, P: 1-8
Distinctively different human neurobiological responses after trauma exposure and implications for posttraumatic stress disorder subtyping

Suji Lee
Sujung Yoon
In Kyoon Lyoo
Research28 Feb 2023
Molecular Psychiatry

Volume: 28, P: 2964-2974
The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory

Boyoung Lee
Eunyoung Bang
Hee-Sup Shin
ResearchOpen Access13 Sept 2018
Scientific Reports

Volume: 8, P: 1-14
Association between social support and postpartum depression

Hahyeon Cho
Kyeongmin Lee
Kui Son Choi
ResearchOpen Access24 Feb 2022
Scientific Reports

Volume: 12, P: 1-9
Weight control behaviors according to body weight status and accuracy of weight perceptions among Korean women: a nationwide population-based survey

Boyoung Park
Ha Na Cho
Yumie Rhee
ResearchOpen Access24 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
Long-term Intracellular Recording of Optogenetically-induced Electrical Activities using Vertical Nanowire Multi Electrode Array

Jisoo Yoo
Hankyul Kwak
Heon-Jin Choi
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Diverging roles of the anterior insula in trauma-exposed individuals vulnerable or resilient to posttraumatic stress disorder

Hyeonseok Jeong
Yong-An Chung
In Kyoon Lyoo
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation

Joohyeon Hong
Go Eun Ha
Eunji Cheong
ResearchOpen Access01 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual

Yeomin Yun, Sung-Ah Hong et al. compare the whole-genome sequence from a male with amyotrophic lateral sclerosis (ALS) to his healthy parents, identifying the M1311V variant in the X-lined ATP7A gene. They show that CRISPR-mediated gene correction in patient-derived neurons rescues neuronal activity.

Yeomin Yun
Sung-Ah Hong
Yoon Ha
ResearchOpen Access20 Jan 2020
Communications Biology

Volume: 3, P: 1-10
Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma

Eunji Shin
Yong Chul Lee
Joonghoon Park
ResearchOpen Access02 Dec 2015
Scientific Reports

Volume: 5, P: 1-11
Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

Seong-Hoon Kim
Hye Guk Ryu
Kyong-Tai Kim
ResearchOpen Access28 Sept 2015
Scientific Reports

Volume: 5, P: 1-13
A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans

Donha Park
Jeong-Hoon Hahm
Young-Ki Paik
ResearchOpen Access03 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

Ha-Long Nguyen
Young Jae Lee
S Paul Oh
Research29 Aug 2011
Laboratory Investigation

Volume: 91, P: 1554-1563
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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