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Attosecond XUV spectroscopy is reported, focussing on non-Born–Oppenheimer dynamics in molecular gases of light elements. It is shown that the phase of the detected photoelectrons carries information from both vibrational and electronic degrees of freedom.

Nonlinear chiral optical activity is difficult to measure because of weak signal amidst strong achiral background. Here, the authors perform a nonlinear chiral two-dimensional spectroscopic mapping of light-harvesting complex 2 during photoexcitation and observe exciton delocalization.

Zaza and colleagues demonstrate that DNA-PAINT on a spinning disk confocal microscope with optical photon reassignment enables high-resolution imaging across large fields and imaging depths, resolving nanoscale protein organisation in both cells and tissues.

Applying high pressures to a crystalline material usually dramatically alters its properties. Feng et al.now demonstrate, however, that antiferromagnetism in gadolinium-silicon is robust even under pressures that are large enough to compress the volume of the crystal by one seventh.

Combining photofunctionalities in a single molecule is challenging due to inherent detrimental interactions. Here, the authors construct a molecular motor that exhibits photoinduced rotary motion together with bright photoluminescence.

Femtosecond X-ray liquidography is used to track the vibrational wavepacket trajectories of gold atoms in solution, enabling time-resolved observations of the emergence of vibrations and the evolution of the formation of covalent bonds.

Ultracold polar molecules are an excellent platform for quantum science but experiments so far see fast trap losses that are poorly understood. Here the authors investigate collisional losses of nonreactive RbCs, and show they are consistent with the sticky collision hypothesis, but are slower than the universal rate.

Human TNF is required for respiratory-burst-dependent immunity to Mycobacterium tuberculosis in macrophages but seems to be largely redundant physiologically.

Three years of observations with the ExoMars TGO Atmospheric Chemistry Suite have clarified the mechanism of atmospheric water loss from Mars, and particularly the fraction of deuterium compared with hydrogen. Analysis of several isotopologues of water in the mid-atmosphere of Mars shows that atomic H and D are produced at perihelion in relative amounts controlled by photolysis. These atoms are able to escape from the atmosphere.

The use of mega-electronvolt ultrafast electron diffraction combined with resonance-enhanced multiphoton ionization yields data that can reveal the formation and subsequent structural relaxation of a molecular ion on an ultrafast timescale.

The small GTPase Cdc42 is an important regulator of cell polarity that localizes to both the plasma membrane and to the Golgi. Baschieri et al.show that the Golgi pool of Cdc42 is regulated by GM130–RasGRF, and that deregulation of this pathway is associated with loss of polarity and tumorigenesis.

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

Energy transfer from carotenoids to chlorophylls in light-harvesting is still not fully understood, especially in the ultrafast regime. Here, the authors investigate the coherent dynamics of this process in peridinin-chlorophyll a-protein complex via 2D electronic spectroscopy and quantum chemical calculations.

Carbon monoxide is the main C and O reservoir in interstellar media, where it undergoes photochemistry. The authors show that isotopic substitution affects not only its absorption. spectrum and photodissociation rates but also the branching ratio, key to understand isotopic. fractionation in the solar system

Excited state aromaticity gives rise to unique photophysical properties which may aid the design of functional photoactive materials. Here, the authors spectroscopically characterize an acceptor-donor-acceptor system featuring a two-electron transfer process stabilized by aromatization in the lower energy excited state.

Annular semiconductor structures, or “quantum rings”, are of interest for quantum information and photonics applications. Here, the authors show that breaking rotational symmetry through elongation generates an in-plane optical transition dipole moment in CdSe quantum rings.

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive heterogeneity and microenvironmental co-evolution.

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

The conversion efficiency of organic solar cells suffers from their low open-circuit voltages. Here, the authors expose a link between electron-vibrations coupling and non-radiative recombinations, derive a new limit for the efficiency of organic solar cells, and redefine their optimal optical gap.

Whole-metagenome sequencing of 1,780 raw-material, end-product and surface samples from 113 food processing facilities reveals the occurrence of antimicrobial resistance determinants in foods and their processing environments.

Sea-level rise in African large marine ecosystem has accelerated markedly since 2010, mostly due to ice sheet loss and land subsidence, with the Red Sea and Guinea Current rising fastest, according to an analysis of 30 years of satellite altimetry data

Lateral anchoring of heteromolecules to graphene paves the way for the creation of hybrid materials with tunable properties. Now, following a surface-assisted dehydrogenative coupling reaction, the edges of graphene on silver have been functionalized with porphines. This enables the assembly of well-defined multifunctional graphene-based nanostructures.

Biomembranes can transmit forces over cellular length scales. Now, however, their active role in generating stress is demonstrated. The adhesion and spreading of a liposome that has no active cytoskeletal machinery are shown to contract the substrate, exerting traction stresses that are comparable with those of living cells.

A thermodynamic study of doped single crystals of NbFe₂ reveals the phase diagram of this system as a function of temperature, magnetic field and Nb doping — which includes an unusual quantum tricritical point.

A nanoscale set–reset machine — the simplest logic circuit with a built-in memory — that operates at room temperature can be created by attaching a silicon nanoparticle to the inner pore of a protein.

Synthetic heterodimers provide a platform to demonstrate molecular design principles of vibronic coupling. Now, it has been shown that quantum beating caused by vibronic coupling can be controlled by packing a structurally flexible heterodimer on single-walled carbon nanotubes. This quantum beating requires a vibration to be resonant with the energy gap between excited states and structural rigidity.

The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the viral oncogene Tax.

Here, the authors report the coupling between a single dye molecule and plasmonic nanocavity at room temperature. They provide insight into the statistical properties of the emission and observe non-classical emission, with photon bunching and anti-bunching regimes dependent on the excitation wavelength.

A program regulating replication origins ensures the exact duplication of vertebrate genomes. The authors identify a combination of guanine-rich motifs, known to form secondary DNA structures, which are sufficient to assemble efficient replication origins.

Here, the authors produce an updated termite classification with genomic scale analyses, highlighting thirteen family-level lineages and resilience of their classification to future termite research.

Kim and colleagues perform a phase 2 clinical trial (ELM-2) of odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma and report on the primary analyses of the efficacy and safety profile.

Photoinduced isomerization reactions, including ring-opening reactions, lie at the heart of many chemical processes in nature. The pathway and dynamics of the ring opening of a model heterocycle have now been investigated by femtosecond photoelectron spectroscopy combined with ab initio theory, enabling the visualization of rich dynamics in both the ground and excited electronic states.

Puzzarini and colleagues explore the computational characterization of medium-sized molecular systems using different spectroscopic techniques. The Primer provides essential information about the characteristics, accuracy and limitations of current computational approaches used for modelling spectroscopic phenomena with a focus on estimating error bars, limitations and coupling interpretability to accuracy.

Defects in silicon carbide represent a viable candidate for realization of spin qubits. Here, the authors show stable bidirectional charge state conversion for the silicon vacancy and divacancy, improving the photoluminescence intensity by up to three orders of magnitude with no effect on spin coherence.

Galectin-3 (Gal-3) has been proposed to have a pathogenic role in systemic sclerosis (SSc). Here, the authors identify a Gal-3-based transcriptomic signature associated with SSc severity in patients and demonstrate that Gal-3 blockade reduces the severity of SSc skin and lung lesions in murine models.

High-resolution measurements of Martian atmospheric dust, water and semiheavy water, obtained by the ExoMars Trace Gas Orbiter during a global dust storm on Mars, are reported.

Isotope effects provide deep insight into mechanisms of chemical and biochemical processes. Now, it has been shown that the pattern of isotopic substitution of the isomerizing bond of the retinal chromophore in the visual pigment rhodopsin significantly alters the reaction quantum yield—revealing a vibrational phase-dependent isotope effect.

Analysis of 20 chemical and morphological plant traits at diverse sites across 6 continents shows that the transition from semi-arid to arid zones is associated with an unexpected 88% increase in trait diversity.