Search

Most H₂ used in the chemical industry is derived from fossil fuels. Now it has been shown that coupling native microbial H₂ pathways with engineered alkene biosynthesis and membrane-bound Pd catalysis enables biocompatible hydrogenation of metabolic intermediates in living bacteria. This hybrid chemo-microbial platform supports the carbon-negative synthesis of industrial chemicals from waste-derived feedstocks.

N-terminal acetylation shapes protein fate during protein biosynthesis at the ribosome. Here the authors show that the NatA enzyme forms dynamic multi-factor complexes at the ribosome, acting as an interaction hub that coordinates cotranslational protein maturation.

NiPS₃ is a van der Waals material, which in the bulk is antiferromagnetic. Whether the antiferromagnetism persists down to the monolayer remains a topic of debate. Here, through magnetotransport measurements Cheon et al find that monolayer NiPS₃ exhibits two magnetic transitions, with a low temperature long-range ordered state.

Men and women differ in their lipid biology. Here, the authors identify NCOA1 as a female-specific regulator that promotes the conversion of white fat into energy-burning fat, protecting women from obesity and metabolic disease by enhancing thermogenic activity in subcutaneous fat.

Using pear as a study system, the biosynthetic pathway of acetophenones has been elucidated: naturally impaired side-chain shortening of aromatic 3-ketoacyl-CoAs leads them to undergo hydrolysis, followed by decarboxylation, to yield acetophenones.

How white matter develops along the length of major tracts in humans remains unknown. Here, the authors identify fundamental patterns of human white matter development along distinct axes that reflect brain organization.

After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.

The study reports the discovery of a persistent bow shock around a diskless magnetic accreting white dwarf, revealing a powerful energy-loss mechanism that challenges current models of accretion and compact binary evolution.

Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.

This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein production and stops phage replication.

People use generative language models to inform all aspects of their lives. Here, the authors examine synthetic narratives produced by open-ended prompting of generative language models and identify patterns of omission, subordination, and stereotyping against minoritized intersectional subgroups.

The formation of exciton crystals is challenging because excitons possess short lifetimes and exhibit weaker interactions than electrons. Now, an exciton Wigner crystal is observed in a moiré electron–hole bilayer.

Neural mechanism underlying behavioural flexibility is not fully understood. Here authors study decision-making of macaques in a reversal task. They identify two complementary cognitive processes. Distinct neural patterns link these processes to the dorsomedial prefrontal cortex, thalamus, and hippocampus.

Combining metabolic theory with global datasets, Li et al. show that root water content is a stronger predictor of root growth traits than the widely considered root nitrogen, better reflecting fast acquisition strategies and leaf–root alignment.

Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be potentially targeted for improved immunotherapy.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

Here the authors spatially map tuberculosis granulomas from nonhuman primates to link structure and immune organization with bacterial control. They find that a conserved hypoxic myeloid core is associated with dysfunctional immunity, restricted lymphocyte access and increased bacterial burden.

A cortical premotor network in HVC, once initiated, can sustain and regulate the sequential production of zebra finch song syllables without major extrinsic inputs.

Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that enables regulated substrate cleavage.

Rak et al. report the visualisation of internal domain boundaries in perovskite single crystals, revealing that electric fields produced by localised flexoelectricity separate electric charges, reducing recombination of charge carriers, and leading to long-lived photocurrent under zero bias.

In a case series of eight pediatric patients with systemic lupus erythematosus, dermatomyositis or systemic sclerosis, autologous anti-CD19 CAR T cell therapy was feasible, safe and effective in reducing disease activity.

A cellular neural network that incorporates transistors and multilevel non-volatile memristor synapses can be used for efficient image and video processing.

Jacquemyn et al. identify key lipid determinants controlling ectosome shedding from neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with relevance to Parkinson’s disease pathology.

Micromitophagy is found to occur in plant male germline cells, mediated by ATG5–HSP90.2 signalling, and is evolutionarily conserved in angiosperms. This mechanism underpins paternal mitochondrial elimination and supports the zygote-to-embryo transition.

Genome-wide analyses in the Norwegian HUNT study with replication in Swedish and Finnish cohorts identify host genetic variants associated with gut microbiome features and provide evidence of a causal effect of body mass index on gut microbiota composition.

An outbreak of MPXV in sooty mangabeys in Côte d’Ivoire was linked to MPXV-infected fire-footed rope squirrels, providing direct evidence of interspecies transmission and indicating risk for zoonotic transmission of MPXV from both hosts.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages share functional analogies but are not homologous, providing an example of convergent evolution.

Carboxysomes are cyanobacterial CO₂-concentrating compartments with a proteinaceous shell. The elucidation of the role of the shell adaptor protein ApN in stepwise β-carboxysome assembly will aid the engineering of these structures in plants.

Although genome editing has transformed plant research, delivering editing reagents remains challenging. This study reports the use of viral vectors to deliver engineered eTnpBc, achieving high levels of somatic and heritable editing in plants.

The lowest-frequency gravitational wave background may be shaped by supermassive black hole binaries that scatter nearby stars or dark matter. In this case, the NANOGrav 15-year dataset favours dense galactic centres with 10⁶ solar masses per cubic parsec.

CABLE harnesses cytoarchitectural information such as cell or nuclear shape to infer fiber tracts in the brain of, for example, marmosets, macaques or humans.

Nitrate sensing by NLP7 engages a MEKK–MAPK cascade to phosphorylate the circadian clock protein CCA1, establishing a positive-feedback loop that stimulates auxin signalling to drive root foraging for nitrate.

Using a mouse model with a macrophage-specific DNA repair defect, Niotis, Arvanitaki et al. identify DNA damage-induced autophagy in macrophages as a link from aging to autoimmunity.

This work introduces BraDiPho, an open-access resource of interactive 3D human brain models, integrating layer-by-layer dissections with tractography, cortical parcellations, and tools for multimodal white matter anatomical studies.

This study introduces two new measures of brain function at the gray–white matter boundary, revealing distinct patterns of signal transmission and metabolic activity that deepen our understanding of brain organization and development.

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with retrotransposon-rich centromeres and that long-terminal-repeat retrotransposons are the genetic substrate.

Using inbred medaka strains, the authors mapped 59 genetic loci linked to heart rate. Gene editing validated conserved genes affecting heart rate and morphology, highlighting the power of isogenic strains in uncovering mechanisms of cardiac traits and disease.

Plant roots elongate under mild nitrogen deficiency as part of a foraging response that facilitates nutrient uptake. Here the authors show that natural variation in this response among Arabidopsis accessions depends on the brassinosteroid (BR) signaling kinase BSK3, which can enhance BR sensitivity and root growth.

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

This study of magic-angle twisted trilayer graphene moiré superconductors using scanning tunnelling microscopy and spectroscopy identifies two energy gaps that develop from many-body resonance in this highly tunable class of materials.

A CT-visualized method is developed for hypersensitive detection of single millimeter vascular emboli derived from surgical adhesives by simply doping BiOCl into the adhesive matrix, which enables a significant improvement in the biosafety of surgical adhesives in preclinical models.

How aperiodic 1/f noise drives ripple activity in human brain and impacts on ripple detections is not fully understood. Here authors show that ripple detections should be driven by the 1/f noise, which indexes different brain states and cognitive demands.

Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

A rationally designed assay detects granzyme A activity by integrating peptide-based GzmA-targeted inhibitors and probes with chemiluminescent reporters to monitor inflammatory bowel disease.

Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence in mice.