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Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Polyneuropathy causes are difficult to pinpoint. Here, authors used single-nucleus and spatial transcriptomics of 37 human peripheral nerves to identify focal perineurial hyperplasia and endoneurial lipid-associated macrophages in polyneuropathies.

Exome sequencing within a structured diagnostic process for rare diseases in Germany shows how facial image analysis and machine learning can guide variant prioritization and uncover many ultrarare diseases.

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

China’s continuing reliance on coal in district heating risks considerable carbon lock-in and hinders decommissioning of coal-fired electricity generation. This work outlines how the government can achieve its proposal to decarbonize district heating.

Wastewater surveillance of SARS-CoV-2 at the national scale tracks emerging variants.

China’s coal-dominated power system is a source of carbon emissions, local air pollution and water stress. This study presents three power system development scenarios that run until 2030 in China, where coal strategies are optimized under current environmental regulations and varying prices for air pollutant emissions and water.

Flexomagnetism refers to the modification of the magnetic properties of a material due to inhomogeneous strain, and offers a promising pathway to the control and manipulation of magnetism. Here, Makushko et al. explore flexomagnetism in antiferromagnetic thin films of Cr₂O₃, demonstrating a gradient of the Néel temperature as a result of an inhomogeneous strain.

High resolution characterisation of the virus specific T cell response to SARS CoV2 provides further understanding to the immune response to the infection. Here the authors apply a reverse phenotyping approach to interrogate the SARS-CoV-2 T cell compartment at single cell resolution.”

A quantification of PM_2.5 pollution finds that mortality risk lies disproportionately within low-income households, and that addressing their indoor air pollution sources can avert more absolute deaths, yet wealthier individuals are more responsible for the emissions.

Electrochemical reduction of CO₂ can yield many different products; a better understanding of the key mechanisms at play is needed to guide the design of selective catalysts. Here the authors use in situ surface-enhanced Raman spectroscopy and simulations to elucidate reaction schemes for CO₂ reduction to ethylene and ethanol.

An adjuvanted SARS-CoV-2 spike-ferritin nanoparticle vaccine can elicit antibodies with relatively broad sarbecovirus activity in non-human primates. Here, the authors isolate and structurally characterize several monoclonal antibodies providing insights into the targeted epitopes and broad reactivity.

Trans-synaptic tau spread drives neurodegeneration in Alzheimer’s disease. This study shows that GAP-43, a marker of synaptic abnormality, is linked to faster tau spread, showing that synaptic changes may contribute to tau spreading in Alzheimer’s disease.

The enzymatic breakdown of the lipid sphingomyelin is associated with various infectious diseases. Here, the authors introduce trifunctional sphingomyelin derivatives for the visualisation of sphingomyelin distribution and sphingomyelinase activity in infection processes.

Therapeutic interference with the immune response after myocardial infarction holds the potential to close a clinically relevant gap. Here, the authors show that inhibition of a cardiomyocyte-specific ADAM10 / CX3CL1 axis improves post infarction survival and cardiac function by attenuating neutrophil-mediated myocardial damage.

An atlas of noncoding RNA in aging and rejuvenated mice identifies a set of deregulated miRNAs.

Aerosol impacts have not been comprehensively considered in the cost-benefit integrated assessment models that are widely used to analyze climate policy. Here the authors account for these impacts and find that the health co-benefits from improved air quality outweigh the co-harms from increased near-term warming, and that optimal climate policy results in immediate net benefits globally.

The cryo-electron microscopy structure of the filamentous hydrogen-dependent CO₂ reductase (HDCR) enzyme from Thermoanaerobacter kivui, together with enzymatic analysis and in situ cryo-electron tomography, provides insight into the high catalytic activity of HDCR.

Children are less likely to be infected with SARS-CoV-2 and develop less severe disease than adults, which makes estimation of infection rates challenging. Here, the authors conduct seroprevalence surveys of children in Germany, describe changes in prevalence over time, and identify risk factors for infection.

In the ongoing phase 1/2 BNT211-01 trial, CLDN6-specific chimeric antigen receptor (CAR)-T cells given with or without CARVac, a CAR-T cell-amplifying RNA vaccine, were well-tolerated and exhibited encouraging clinical activity in patients with relapsed or refractory CLDN6-positive solid tumors, with the highest response rate in patients with germ cell tumors.

Intermittency is often cited as the single greatest hurdle to making a transition from a fossil-based power system to one based on renewables. This study shows that a network of solar power plants, located in deserts, could provide significant baseload in four world regions, suggesting that decarbonization of the power system may be possible and affordable, even if no new technologies come online.

A tethered macrocyclic peptide antibiotic class described here—which shows potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii—blocks the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane through inhibition of the LptB₂FGC complex.

Most inhabited areas in the US have more mass in buildings and mobility networks than in plant biomass. Cities are comparably resource efficient, while high material intensity is found in rural areas. Migration reinforces this phenomenon as people leave while built structures remain.

This study identifies three conserved shadow enhancers (T3, C, I) regulating notochord expression of Brachyury across vertebrates using genomic data, transgenic assays, and enhancer knockouts, which are critical for vertebrate notochord development.

To enable net-negative CO₂ emissions, the repayment of previously accrued carbon debt by establishing the responsibility for the net removal of CO₂ by carbon-emitting parties through carbon removal obligations is necessary.

Blockade of lymphotoxin β-receptor (LTβR) signalling restores WNT signalling and epithelial repair in a model of chronic obstructive pulmonary disease.

A novel study led by scientists in Lübeck, Germany, shows that SARS-CoV-2-infected brain endothelial cells undergo cell death due to the cleavage of NEMO by the viral protease M^pro, potentially causing cerebral COVID-19 and ‘long COVID’ symptoms.

Semiconducting single crystals of doped barium titanate and titanium dioxide exhibit a flexoelectric-like response upon bending that is much larger than in their undoped, insulating counterparts, reaching unprecedentedly large effective flexoelectric coefficients.

High-throughput single particle cryo-EM, for instance in drug research, requires the automation of the single particle analysis workflow. Here, the authors present TranSPHIRE, a software package that allows the fully-automated, feedback-driven processing of cryo-EM datasets during data acquisition.

Early humoral responses to malaria fail to induce durable protective antibodies. Butler and colleagues report that low-affinity, short-lived plasmablasts become nutrient sinks for glutamine and starve germinal center B and T cells, thereby reducing the generation of high-affinity B cells and long-lived plasma cells and memory B cells.

microbeMASST is a tool to associate known and unknown metabolites to microbial producers leveraging untargeted metabolomics data.

We find that if all countries adopt the necessary uniform global carbon tax and then return the revenues to their citizens on an equal per capita basis, it will be possible to meet a 2 °C target while also increasing wellbeing, reducing inequality and alleviating poverty. These results indicate that it is possible for a society to implement strong climate action without compromising goals for equity and development.

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

An antiferromagnet with a correlation length that encompasses the whole system is created with the aid of quantum gas microscopy of cold atoms in an optical lattice.

Transcript cleavage factors such as eukaryotic TFIIS assist the resumption of transcription following RNA pol II backtracking. Here the authors find that one of the Sulfolobus solfataricus TFIIS homolog—TFS4—has evolved into a potent RNA polymerase inhibitor potentially involved in antiviral defense.

Structures of surfaces and thin films can be investigated by performing X-ray diffraction under grazing incidence conditions. This Primer explores how grazing incidence X-ray diffraction is used to obtain crystallographic information, including in situ characterization, data collection, analysis and visualization, across a range of applications.

Mitigation scenario ensembles are becoming an important tool to bring new and robust insights into the transition to net zero. This Perspective unpacks their potential and identifies key steps for better use of scenario ensembles and to foster good practices.

Climate policy analyses often ignore the possibility of progressive redistribution of carbon tax revenues and assume that mitigation cost will burden the poor in the short term. Integrated Assessment Model (IAM) estimation suggests such redistribution could reduce inequality, alleviate poverty and increase well-being globally.