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Manipulating the physical properties of solid matter using only photons is a major challenge in materials science. Here, the authors present the photochemistry occurring in a single crystal of a Mo(III) cyanide complex which undergoes a reversible breaking and reformation of dative bonds and spin state change upon exposure to visible light.

In this single-arm phase 2 trial in patients with HR⁺HER2⁻ advanced breast cancer, treatment with the HER3-targeting antibody–drug conjugate paritumab deruxtecan led to encouraging objective response rates, and comprehensive exploratory analyses indicate potential biomarkers of response.

Debio 1453, a FabI inhibitor, shows potent activity against antibiotic-resistant Neisseria gonorrhoeae, rapidly killing bacteria in vitro and clearing infection in mice, supporting its potential for treating drug-resistant gonorrhoea.

A high-resolution virtual brain twin approach is proposed using stimulation-induced seizures to estimate the epileptogenic network, offering a step toward non-invasive diagnosis and treatment of drug-resistant focal epilepsy.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

The Patagonian ice sheet not only responded to climate change but also actively influenced it regionally, highlighting the role of topographic forcing in shaping atmospheric circulation during glacial-interglacial cycles, according to a modeling study.

Kroemer and colleagues discuss evidence supporting the importance of immunosurveillance in natural and therapy-induced killing of breast tumors.

The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the authors report that BRCA1/2 and ADAR1 are synthetic lethal, showing that ADAR1 depletion in BRCA1-mutant cells causes autocrine interferon poisoning

Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also reveal links between Pitx1 expression and genome topology.

Borcoman and colleagues present the efficacy and safety results of the phase 2 PEVOsq basket trial investigating the combination of pembrolizumab with the epidrug vorinostat in patients with recurrent and/or metastatic squamous cell carcinoma.

Phosphorus mononitride is highly unstable under atmospheric conditions and its utility for constructing elusive P–N π-bonded motifs has remained uncertain. Here, the authors show that Na(OCP) can transfer a P atom to an electrophilic osmium nitride complex to form a metal-bound P≡N ligand.

Barlesi and colleagues describe the determinants of severe COVID-19 outcomes in patients with cancer managed at the Gustave Roussy Cancer Centre.

Switches made up of single molecules form the basis for the concept of molecular electronics. Miyamachiet al.demonstrate that an iron-based spin crossover molecule can be switched between different spin states, provided it is decoupled from a metallic substrate by a thin insulating layer.

The Q-cycle is thought to be an essential energetic component of the photosynthetic electron-transfer chain. Here, Chlamydomonas mutants with an inactive Q-cycle but normal levels ofb₆fcomplexes are shown to display photosynthetic growth, demonstrating the dispensability of the Q-cycle in the oxygenic photosynthetic chain.

Rapid local adaptation could potentially facilitate the recolonization of restored habitats. Here, the authors show that reed warblers have undergone substantial adaptive change in body mass in only 19 years after colonizing a restored wetland in Malta.

This study documents the deglacial intensified northward flow of high pCO2 Antarctic Intermediate and Mode Water in the Pacific Ocean and provides support for these water masses as one important conduit for oceanic outgassing in the eastern equatorial Pacific upwelling.

At interfaces between systems with topologically distinct band structure, robust symmetry protected states emerge. Here, Poli et al.control such states in a coupled dielectric resonator chain with parity-time symmetry and exploit their topological nature to protect them from absorptive losses.

A collaborative study initiated by the sovereign nation of Picuris Pueblo in the Northern Rio Grande region of New Mexico addresses gaps in traditional knowledge and furthers understanding of their population history and ancestry.

Trastuzumab deruxtecan, an anti-HER2–drug conjugate, exhibits the highest objective response rate in patients with HER2-overexpressing metastatic breast cancer, but clinical activity is also observed in patients with HER2-low or non-expressing tumors, potentially pointing to additional determinants of drug efficacy.

How mountain glaciers will react to temporarily overshooting 1.5 °C of warming is poorly understood. Here the authors show irreversible global glacier loss for centuries after overshoot, implying long-term reductions in glacial water resources with amplified impacts in regions where glaciers regrow.

The Berezinskii–Kosterlitz–Thouless transition is observed in a 2D gas of exciton-polaritons, through measurements of the first-order coherence both in space and time.

In this work, authors probe the molecular mechanism of re-emerging CHL susceptibility in Malawian Enterobacterales isolates, where they identify a stable truncation of resistance genes by insertion sequences.

Recent seismicity near Mayotte in the Indian Ocean is due to dyke propagation from and drainage of a 25–35 km deep magma reservoir, according to an analysis of earthquake and deformation data.

Photonic crystals efficiently control wave propagation on a wavelength scale, but this means they can become very large when long wavelengths are involved. Metamaterials made of resonant unit cells can confine and guide waves even at scales far below their wavelength.

Targeted therapies matched to genomics improved progression-free survival when genomic alterations were classified as level I/II (according to ESCAT), and genomics should thus be driven by target actionability in patients with metastatic breast cancer.

Tumor-derived soluble PD-L1 drives immune checkpoint inhibitor (ICI) resistance and has recently been reported to be removed by therapeutic plasma exchange (TPE). Here, the authors report a phase I clinical trial investigating the combination of radiotherapy, TPE, and ICI rechallenge in patients with ICI-refractory metastatic melanoma with high PD-L1.

Droplet microfluidics offer a convenient platform for high-throughput experimentation. It has been difficult, however, to rapidly and controllably vary concentration — a key process used in macro-scale experiments. Here, a droplet dilution module is described that traps a mother droplet and then repeatedly dilutes it releasing a series of droplets that define a digital concentration gradient.

Cartron et al. report the results of a phase 2 trial of the CD20–CD3 T cell-engaging bispecific antibody glofitamab in refractory or relapsed diffuse large B cell lymphoma after failing chimeric antigen receptor T cell therapy.

The transcriptional regulation of mitochondrial oxidative phosphorylation gene expression is poorly understood. Using the developing Drosophila flight muscle, the authors identify the transcription factor M1BP as a new major regulator of this process.

The Intergovernmental Panel on Climate Change and the Paris agreement must align their schedules — or progress will slip.

Pangenome analyses of 133 wild accessions of the model bryophyte Marchantia polymorpha identify adaptive features and provide insights into the mechanisms of plant adaptation to the terrestrial environment.

The histone variant, H2A.Z is known to regulate gene expression and cell proliferation. Here the authors show that H2A.Z has a central role in the control of intestinal epithelial homeostasis in mice, by preventing terminal differentiation of intestinal progenitors.

Hibernating brown bears maintain their muscle mass, which is due to a drastic reduction in metabolic rate. Here, De Napoli et al. show that this is partly due to a reduction of energy consumption by the motor protein myosin in resting skeletal muscle that increases the super relaxed state stability.

In this prespecified interim analysis of the KEYNOTE-756 phase 3 trial, pembrolizumab and chemotherapy treatment of patients with high-risk, early-stage, estrogen receptor-positive/human epidermal growth factor receptor-negative breast cancer improved the pathological complete response rate compared with chemotherapy alone.

Fougère, Grison et al. show that the ER–Golgi intermediate compartment (ERGIC) in plants is a tubulo-vesicular network marked by MEMBRIN proteins that is largely Golgi-independent. The plant ERGIC matures into Golgi cisternae, in a process that depends on sphingolipids.