Nature Search

Stabilized D₂R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes

G protein-coupled receptor di/oligomers can diversify signaling and play roles in disease. Here authors stabilized D2 dopamine receptor di/oligomers that may selectively favor complexes with the adaptor protein β-arrestin2 to bias receptor activity.

Katie L. Sharrocks
Francesca Fanelli
Aylin C. Hanyaloglu
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

Kazzem Gheybi
Pamela X. Y. Soh
Vanessa M. Hayes
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-16
RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation

Francesca Romana Liberati
Sharon Spizzichino
Francesca Cutruzzolà
ResearchOpen Access06 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-10
Molecular mechanism of Cinnamomum zeylanicum and Citrus aurantium essential oils against the root-knot nematode, Meloidogyne incognita

Elena Fanelli
Alessio Vovlas
Francesca De Luca
ResearchOpen Access19 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Comparative analysis of library preparation approaches for FFPE gene expression profiling and related recommendations

Sara Pignatta
Marcella Tazzari
Jenny Bulgarelli
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
Distinct mesenchymal cell states mediate prostate cancer progression

The components of the tumour microenvironment contribute to prostate cancer initiation and progression. Here the authors perform single-cell RNA sequencing and spatial transcriptomics analysis of prostate cancer stroma from mouse models at different stages of the disease and develop a gene signature to predict distant metastasis in patients.

Hubert Pakula
Mohamed Omar
Massimo Loda
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-21
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation.

Diletta Fontana
Mario Mauri
Rocco Piazza
ResearchOpen Access23 Nov 2020
Nature Communications

Volume: 11, P: 1-16
The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition

Mutations in the RAB39Bgene, which encodes a protein involved in vesicular trafficking, are associated with intellectual disability, but the impact of RAB39B loss of function on synaptic activity is not known. Here the authors show that RAB39B interacts with PICK1, and that this interaction is critical for the translocation of AMPA receptor subunits into the Golgi.

Maria Lidia Mignogna
Maila Giannandrea
Patrizia D’Adamo
ResearchOpen Access18 Mar 2015
Nature Communications

Volume: 6, P: 1-15
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABA_BRs shapes inhibitory neurotransmission

Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABA_Breceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiety-like behaviour and seizures.

Jonathan Zapata
Edoardo Moretto
Maria Passafaro
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-17
Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Stefano Amatori
Giuseppe Persico
Mirco Fanelli
ResearchOpen Access19 Dec 2022
Cancer Gene Therapy

Volume: 30, P: 671-682
Mapping the allosteric network within a SH3 domain

Francesca Malagrinò
Francesca Troilo
Stefano Gianni
ResearchOpen Access04 Jun 2019
Scientific Reports

Volume: 9, P: 1-6
Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells

Stefano Amatori
Luca Mazzoni
Maurizio Battino
ResearchOpen Access08 Aug 2016
Scientific Reports

Volume: 6, P: 1-13
Expanding the mutational spectrum of ReNU syndrome: insights into 5’ Stem-loop variants

Alessandro Bruselles
Cecilia Mancini
Marco Tartaglia
Research26 Feb 2025
European Journal of Human Genetics

Volume: 33, P: 432-440
Blood pressure variability as predictor of cancer therapy-related cardiovascular toxicity in patients with Multiple Myeloma

On the left panel in the figure, the distribution of blood pressure variability (BPV) in the population according to cancer therapy-related cardiovascular toxicity occurrence; in the central panel, association of blood pressure variability with events and cutoffs values; in the right panel, clustering analysis results based on BPV levels. Histogram and radar plot represent events and BPV indexes distribution in the three clusters, respectively. ARV, average real variability; BPV, Blood Pressure Variability; CTR-CVT, cancer therapy-related cardiovascular toxicity; CoV, coefficient of variation; DBP, Diastolic blood pressure; SBP, Systolic blood pressure; SD, standard deviation; VIM, variability independent of the mean; wSD, weighted standard deviation.

Elvira Fanelli
Giulia Picca
Fabrizio Vallelonga
Research22 Jan 2025
Hypertension Research

Volume: 48, P: 1554-1563
Effect of neurally adjusted ventilator assist versus pressure support ventilation on asynchronies and cardiac function in pediatric liver transplantation

Fabrizio Chiusolo
Giorgia Spinazzola
Giorgio Conti
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity

Lung cancer is a very aggressive tumor that often forms brain metastases. We show that lung cancer cells motility, fundamental for the formation of metastases, is controlled by amino acids such as serine and glycine, abundant in brain microenvironment.

Amani Bouzidi
Maria Chiara Magnifico
Francesca Cutruzzolà
ResearchOpen Access26 Nov 2020
Cell Death & Disease

Volume: 11, P: 1-14
The kinetics of folding of the NSH2 domain from p85

Lorenzo Visconti
Francesca Malagrinò
Stefano Gianni
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-6
Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment

Francesca Sardina
Federica Polverino
Cinzia Rinaldo
ResearchOpen Access07 Feb 2025
Cell Death Discovery

Volume: 11, P: 1-9
GBS-derived SNP catalogue unveiled wide genetic variability and geographical relationships of Italian olive cultivars

Nunzio D’Agostino
Francesca Taranto
Cinzia Montemurro
ResearchOpen Access26 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2

Mario Brufani
Nicoletta Rizzi
Adriana Maggi
ResearchOpen Access31 May 2017
Scientific Reports

Volume: 7, P: 1-14
The second will be first: competition on directed networks

Giulia Cencetti
Franco Bagnoli
Duccio Fanelli
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Optimal search strategies on complex multi-linked networks

Francesca Di Patti
Duccio Fanelli
Francesco Piazza
ResearchOpen Access07 May 2015
Scientific Reports

Volume: 5, P: 1-6
SIRT6 promotes metastasis and relapse in HER2-positive breast cancer

Cristina Andreani
Caterina Bartolacci
Augusto Amici
ResearchOpen Access12 Dec 2023
Scientific Reports

Volume: 13, P: 1-22
Mutation landscape in patients with myelofibrosis receiving ruxolitinib or hydroxyurea

Annalisa Pacilli
Giada Rotunno
Paola Guglielmelli
ResearchOpen Access22 Nov 2018
Blood Cancer Journal

Volume: 8, P: 1-10
Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons

Alessandro Soloperto
Deborah Quaglio
Alberto Boffi
ResearchOpen Access28 Mar 2022
Scientific Reports

Volume: 12, P: 1-15
Modulation of thermal noise and spectral sensitivity in Lake Baikal cottoid fish rhodopsins

Hoi Ling Luk
Nihar Bhattacharyya
Massimo Olivucci
ResearchOpen Access09 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

Giovanetti et al. examine SARS-CoV-2 transmission dynamics in Italy using phylodynamic analysis of viral genetic and epidemiological data. They present evidence to suggest that the efficacy of public health interventions is limited by the size and structure of epidemic reservoirs, which may influence vaccination programmes.

Marta Giovanetti
Eleonora Cella
Massimo Ciccozzi
ResearchOpen Access21 Apr 2021
Communications Biology

Volume: 4, P: 1-9
Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome

Elisa Maria Turco
Angela Maria Giada Giovenale
Jessica Rosati
ResearchOpen Access21 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-16
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Sonia Coni
Silvia Maria Serrao
Gianluca Canettieri
ResearchOpen Access10 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-14
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis

Giorgio Giardina
Alessandro Paiardini
Francesca Cutruzzolà
ResearchOpen Access15 Sept 2017
Scientific Reports

Volume: 7, P: 1-11

Search

Stabilized D₂R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes

Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry

RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation

Molecular mechanism of Cinnamomum zeylanicum and Citrus aurantium essential oils against the root-knot nematode, Meloidogyne incognita

Comparative analysis of library preparation approaches for FFPE gene expression profiling and related recommendations

Distinct mesenchymal cell states mediate prostate cancer progression

ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition

Epilepsy and intellectual disability linked protein Shrm4 interaction with GABA_BRs shapes inhibitory neurotransmission

Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Mapping the allosteric network within a SH3 domain

Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells

Expanding the mutational spectrum of ReNU syndrome: insights into 5’ Stem-loop variants

Blood pressure variability as predictor of cancer therapy-related cardiovascular toxicity in patients with Multiple Myeloma

Effect of neurally adjusted ventilator assist versus pressure support ventilation on asynchronies and cardiac function in pediatric liver transplantation

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity

The kinetics of folding of the NSH2 domain from p85

Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment

GBS-derived SNP catalogue unveiled wide genetic variability and geographical relationships of Italian olive cultivars

Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2

The second will be first: competition on directed networks

Optimal search strategies on complex multi-linked networks

SIRT6 promotes metastasis and relapse in HER2-positive breast cancer

Mutation landscape in patients with myelofibrosis receiving ruxolitinib or hydroxyurea

Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons

Modulation of thermal noise and spectral sensitivity in Lake Baikal cottoid fish rhodopsins

SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis

Search

Quick links

Search

Filter By:

Search

Quick links