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Giardini et al. present an imaging method that combines quantitative measurements of cardiac electrophysiology with high-resolution three-dimensional structural reconstructions, enabling the detection of arrhythmogenic electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

Standardisation of working with 3D cell cultures in high-content screening (HCS) approaches remains difficult. Here, the authors propose HCS-3DX, a system for HCS of 3D tumour models at single-cell resolution by combining micromanipulation, custom multi-well plates, advanced imaging and AI-based analysis.

Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.

Amino acids possess a new and broad colloidal property: they stabilize patchy nanoscale colloids, such as proteins, by adsorbing onto their surfaces through weak interactions.

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

Coagulation factor IX (FIX) contributes to hemostasis through both plasma activity and binding to extravascular collagen IV. Here, the authors show that collagen binding of albumin-fused hyperactive FIX can be engineered to tailor the pharmacokinetics, distribution, and functional properties in mice for tailored short- or long-term hemophilia B therapy.

Camera-trap data for 159 mammalian species at 1,002 sites across 16 tropical-forest protected areas show how local survival and colonization probabilities of specialist and generalist species are differently affected by human-induced stressors at different spatial scales, such as human population density and forest fragmentation.

The Perseverance rover detected polycyclic aromatic hydrocarbons preserved within sulfates in the fan and floor of Jezero crater on Mars, offering new insights into past habitability and the preservation of organic matter on Mars.

MINFLUX microscopy typically can only continuously localise one fluorescent emitter at a time. Here, the authors present a multiplexing variant using a ratiometric differential emission detection to simultaneously visualise the diffusion of the nicotinic acetylcholine receptor and cholesterol on live-cell plasma membranes.

Mitochondrial dysfunction in dopaminergic neurons is a pathological hallmark of Parkinson’s disease. Here, the authors find a conserved mechanism by which a single transcription factor controls mitochondrial health in dopaminergic neurons during the aging process.

This Review provides an overview of the main applications of single-port robotic surgery in urology, presenting emerging outcomes and discussing the transformative potential of this approach.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The interactions between microplastics and freshwater snow can influence the way in which both particle types settle in freshwater environments. Advanced and automated tracking techniques show that agglomerates of the two particles settle faster than the individual components alone, underscoring the potential repercussions on biogeochemical cycles.

Combined intraocular injection of an adeno-associated viral vector, encoding an optogenetic sensor, with light stimulation via engineered goggles enables partial recovery of visual function in a blind patient.

Scientists demonstrate an experimental method that allows them to locate and track moving targets that are hidden from the direct line of sight, for example, by a wall or an obstacle, with only a few seconds acquisition time and centimetre precision.

Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of hippocampal spike timing - phase precession and sequences - in opposing fashions, suggesting a specific network architecture.

Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.

The whole Salar de Uyuni in Bolivia is not a uniform mirror-like surface in which anything above it is reflected specularly, instead the smoothness of the water surface evolves spatially and temporally, according to an analysis using radar altimeter observations from Sentinel-3 satellites.

An analysis of two post-starburst galaxies at high redshift indicates the presence of ongoing feedback between the stellar material and the supermassive black hole.

Spatially resolved JWST spectroscopy of a massive, quiescent galaxy at a redshift of ~4 reveals that it formed its stars and quenched rapidly, despite being surrounded by an abundant gas reservoir and gravitationally bound to a star-bursting companion.

Integrated field and laboratory investigations, and numerical simulations of the 2019 paroxysmal explosions at Stromboli volcano revealed that they were anticipated by a week-to-month-long destabilization in the normal volcanic activity, a pattern common to all paroxysms.

By combining a single-photon time-of-flight camera with computational processing of the spatial and full temporal photon distribution data, an object embedded inside a strongly diffusive medium can be imaged over more than 80 transport mean free paths in a contactless manner on the timescale of the order of 1 s.

Temporal niche partitioning is an important feature of animal communities. Here, Vallejo-Vargas and colleagues analyze standardized camera trap survey data from protected areas across the tropics to investigate diel patterns of forest mammals in relation to body mass and trophic guild.

Here, the authors show that MacroD1 is important for mitochondrial integrity and function. Lack of MacroD1 resulted in impaired cellular respiration which was particularly detrimental for cells and organs with high energetic requirements, such as skeletal muscle.

Reabsorption losses in luminescent solar concentrators can be avoided by the use of indirect-bandgap semiconductor nanostructures. The technology has been used to demonstrate flexible luminescent solar concentrators with performance comparable to flat concentrators.

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologous recombination in cancer cells, promoting error-prone DNA repair and enhancing sensitivity to PARP inhibitors.

The role of synaptogenesis during the acquisition of goal-directed behaviors is unknown. Here, the authors show that learning-induced synaptogenesis in the adult mouse cortex is required to excite a specific circuit to adjust effort exertion.

Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP granule-lysosome tethering and co-trafficking.

The assumption that light sources based on radiative cascades provide maximally polarization-entangled photons is not always correct. Here the authors show experimentally in cavity-embedded quantum dots that photon polarization correlates with its emission mode, impacting the degree of entanglement for emitted photon pairs.

Stella, Achkar and colleagues present a bio-inspired quadruped robot that uses passive dynamics, motor synergies, variable stiffness and self-organization to achieve robust, adaptive, animal-like movement with just four actuators.

The inner nuclear membrane contains lipid microdomains rich in sphingomyelin and cholesterol, which are the site of transcriptional machinery and contain nuclear miRNAs in high concentrations.

Marine bacteria opt for divergent foraging strategies when faced with carbon starvation—either cease motility entirely, or convert biomass to energy to retain motility.

Robots that can self-assemble into different morphologies are desired to perform tasks that require different physical capabilities. Mathews et al. design robots whose bodies and control systems can merge and split to form new robots that retain full sensorimotor control and act as a single entity.

Systems comprising water and hydrophobic cavities, with scales ranging from nanometres to millimetres, are shown to expand upon compression, an unusual mechanical property of technological and biological relevance known as negative compressibility.

Colourless panels that can concentrate solar light and improve the efficiency of solar cells can now be fabricated with non-toxic quantum dots.

Many networks exhibit patterns of synchronized clusters, but the conditions under which this occurs are poorly understood. Pecora et al. develop an analytical approach based on computational group theory to predict the emergence and disappearance of synchrony among local clusters in complex networks.

Here, the authors upgrade a confocal laser scanning microscope with a single-photon array detector, achieving 40 nm lateral and 60 nm axial localisation precision with 100 photons and a sub-millisecond temporal sampling for real-time single-particle tracking with fluorescence lifetime measurement.

The instability of perovskite solar cells hinders their commercialization. Here, authors report an industrially compatible strain-free encapsulation process based on lamination of highly viscoelastic semi-solid/highly viscous liquid encapsulant adhesive to reduce thermomechanical interfacial stress.

A cultural assembly of traits at a 40,000-year-old archaeological site at Xiamabei, China supports a model of repeated early human expansions, cultural exchange and innovation in east Asia.