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Showing 201–250 of 350 results

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High-dimensional detection of imaging response to treatment in multiple sclerosis

Baris Kanber
Parashkev Nachev
Olga Ciccarelli
ResearchOpen Access10 Jun 2019
npj Digital Medicine

Volume: 2, P: 1-10
Synchronous tropical and polar temperature evolution in the Eocene

A 26-million-year record of equatorial sea surface temperatures reveals synchronous changes of tropical and polar temperatures during the Eocene epoch forced by variations in concentrations of atmospheric carbon dioxide, with a constant degree of polar amplification.

Marlow J. Cramwinckel
Matthew Huber
Appy Sluijs
Research02 Jul 2018
Nature

Volume: 559, P: 382-386
A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women

Bo Anne Daniëlla Frederique Saals
Tessa Helena De Bie
Renger Frederik Witkamp
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Effects of ketone body 3-hydroxybutyrate on cardiac and mitochondrial function during donation after circulatory death heart transplantation

Jacob Marthinsen Seefeldt
Yaara Libai
Niels Moeslund
ResearchOpen Access08 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

Multiple sclerosis is traditionally considered to be an inflammatory disease, but it also has a neurodegenerative component, which can manifest early in the disease course. New therapeutic strategies are being developed to elicit CNS neuroprotection and repair in patients with multiple sclerosis, and Barkhof et al. review the available data on imaging outcome measures that could be used to track the efficacy of these approaches.

Frederik Barkhof
Peter A. Calabresi
Stephen C. Reingold
Reviews01 May 2009
Nature Reviews Neurology

Volume: 5, P: 256-266
The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ

François F. Firmin
Frederik Oger
Philippe Lefebvre
ResearchOpen Access26 Oct 2017
Scientific Reports

Volume: 7, P: 1-16
Allosteric targeting of receptor tyrosine kinases

Frederik De Smet
Arthur Christopoulos
Peter Carmeliet
Reviews07 Nov 2014
Nature Biotechnology

Volume: 32, P: 1113-1120
Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones

Patrick Philipp Weil
Anton Pembaur
Jan Postberg
ResearchOpen Access19 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents

Frederik Jan Moorhouse
Sonia Cornell
Ingo Borggraefe
ResearchOpen Access09 Dec 2020
Scientific Reports

Volume: 10, P: 1-9
Risk factors for SARS-CoV-2 infection and severe COVID-19 in unvaccinated solid organ transplant recipients

Casper Vrij
Kris Bogaerts
Jef Verbeek
ResearchOpen Access02 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
FGF-dependent metabolic control of vascular development

Fibroblast growth factor receptor (FGFR) signalling is a crucial regulator of endothelial metabolism and vascular development.

Pengchun Yu
Kerstin Wilhelm
Michael Simons
Research03 May 2017
Nature

Volume: 545, P: 224-228
Polarity signaling balances epithelial contractility and mechanical resistance

Matthias Rübsam
Robin Püllen
Carien M. Niessen
ResearchOpen Access12 May 2023
Scientific Reports

Volume: 13, P: 1-14
Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

Friederike Christen
Raphael Hablesreiter
Frederik Damm
ResearchOpen Access15 Nov 2021
Leukemia

Volume: 36, P: 1102-1110
MRI monitoring of immunomodulation in relapse-onset multiple sclerosis trials

Lesion activity detected on MRI scans has become an accepted surrogate for disease activity in relapsing–remitting multiple sclerosis (MS). Barkhof and colleagues provide key recommendations for efficient use of MRI in clinical trials for relapse-onset MS, including practical issues related to acquisition, analysis and reporting of MRI data, approaches to optimization of trial design, and safety considerations.

Frederik Barkhof
Jack H. Simon
Massimo Filippi
Reviews06 Dec 2011
Nature Reviews Neurology

Volume: 8, P: 13-21
Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients

Evelien A. J. van Genugten
Theresa J. van Lith
Erik H. J. G. Aarntzen
ResearchOpen Access17 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Dennis Das Gupta
Christoph Paul
Michael Lohoff
ResearchOpen Access22 Apr 2022
Cell Death & Differentiation

Volume: 29, P: 2163-2176
Detection and characterisation of multiple herpesviruses in free-living Western European hedgehogs (Erinaceus europaeus)

Helle B. Hydeskov
Akbar Dastjerdi
Becki Lawson
ResearchOpen Access17 Sept 2018
Scientific Reports

Volume: 8, P: 1-8
Combination p53 activation and BCL-x_L/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Hayden L. Bell
Helen J. Blair
Julie A. E. Irving
ResearchOpen Access10 Apr 2024
Leukemia

Volume: 38, P: 1223-1235
Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids

Stefan Spulber
Mirko Conti
Sandra Ceccatelli
ResearchOpen Access17 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-14
Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice

Lukas Härle
Verena von Bülow
Martin Roderfeld
ResearchOpen Access21 Nov 2023
Scientific Reports

Volume: 13, P: 1-13
Acute-on-chronic liver failure in cirrhosis

Patients with cirrhosis can develop acute-on-chronic liver failure, a syndrome characterized by acute decompensation, organ failure and high short-term mortality. Arroyo et al. discuss the mechanisms, diagnosis and management of this evolving concept in the field of liver disease.

Vicente Arroyo
Richard Moreau
Bernd Schnabl
Reviews09 Jun 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-18
New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer

Jayant S. Vaidya
Max Bulsara
Jeffrey S. Tobias
ResearchOpen Access25 May 2021
British Journal of Cancer

Volume: 125, P: 380-389
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Doug Easton and colleagues report the results of a large-scale genome-wide association study of breast cancer. They discover 15 new susceptibility loci and highlight likely target genes in several of the newly associated regions.

Kyriaki Michailidou
Jonathan Beesley
Douglas F Easton
Research09 Mar 2015
Nature Genetics

Volume: 47, P: 373-380
Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

Younes Kays Mohammed Ali
Troels Gammeltoft Dolin
Louise Lang Lehrskov
ResearchOpen Access03 Jan 2024
International Journal of Obesity

Volume: 48, P: 533-541
Solving ordinary and partial differential equations using an analog computing system based on ultrasonic metasurfaces

Robert Frederik Uy
Viet Phuong Bui
ResearchOpen Access18 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis

Ni Shu
Yunyun Duan
Yaou Liu
ResearchOpen Access12 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
Nutritional and metabolic factors in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease classically thought to impact the motor system, but research is now investigating the contribution of non-motor symptoms. Here, the authors explore evidence that highlights the extent to which nutrition and metabolism might contribute to ALS pathogenesis, and discuss the effectiveness of modifying energy balance in ALS.

Albert Ludolph
Luc Dupuis
Christopher McDermott
Reviews27 Jul 2023
Nature Reviews Neurology

Volume: 19, P: 511-524
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma

Franziska Briest
Daniel Noerenberg
Frederik Damm
ResearchOpen Access30 Aug 2023
Leukemia

Volume: 37, P: 2237-2249
Caecal microbiota composition of experimental inbred MHC-B lines infected with IBV differs according to genetics and vaccination

Marion Borey
Bertrand Bed’Hom
Fanny Calenge
ResearchOpen Access15 Jun 2022
Scientific Reports

Volume: 12, P: 1-14
GAIN2 trial overall survival with intense versus tailored dose dense chemotherapy in early breast cancer

Volker Möbus
Hans-Joachim Lück
Sibylle Loibl
ResearchOpen Access30 Jul 2024
npj Breast Cancer

Volume: 10, P: 1-10
Relativistic-intensity near-single-cycle light waveforms at kHz repetition rate

Marie Ouillé
Aline Vernier
Rodrigo Lopez-Martens
ResearchOpen Access23 Mar 2020
Light: Science & Applications

Volume: 9, P: 1-9
Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation

Alexander Neumann
Fahri Küçükali
Kristel Sleegers
ResearchOpen Access16 Feb 2022
Molecular Psychiatry

Volume: 27, P: 1990-1999
Human gaze tracks attentional focusing in memorized visual space

van Ede et al. show that focusing on a visual representation held in memory biases gaze towards its memorized location. This suggests that gaze control and attentional focusing within memorized space rely on the same system.

Freek van Ede
Sammi R. Chekroud
Anna C. Nobre
Research04 Mar 2019
Nature Human Behaviour

Volume: 3, P: 462-470
Variable training but not sleep improves consolidation of motor adaptation

Benjamin Thürer
Frederik D. Weber
Thorsten Stein
ResearchOpen Access29 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
Beauty is skin deep: the skin tones of Vermeer’s Girl with a Pearl Earring

Annelies van Loon
Abbie Vandivere
Gareth R. Davies
ResearchOpen Access11 Dec 2019
Heritage Science

Volume: 7, P: 1-20
The impact of asthma and COPD in sub-Saharan Africa

Frederik van Gemert
Thys van der Molen
Niels Chavannes
Reviews20 Apr 2011
Primary Care Respiratory Journal

Volume: 20, P: 240-248
Extended methods for spatial cell classification with DBSCAN-CellX

Leonie Küchenhoff
Pascal Lukas
Frederik Graw
ResearchOpen Access01 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Assessing household lifestyle exposures from consumer purchases, the My Purchases cohort

Frederik T. Møller
Thor Grønborg Junker
Mads Melbye
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-12
The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

A genome assembly for Rauvolfia tetraphylla combined with transcriptomic, metabolomic, and proteomic analyses as well as machine learning enables identification of enzymes involved in yohimbane monoterpene indole alkaloid biosynthesis.

Emily Amor Stander
Beata Lehka
Vincent Courdavault
ResearchOpen Access24 Nov 2023
Communications Biology

Volume: 6, P: 1-19
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in vivo half-life extension, cellular cytotoxicity dependent on the cell surface levels of EGFR and can inhibit growth of BRAF mutated EGFR-positive tumours in mice.

Ole A. Mandrup
Sui Ching Ong
Kenneth A. Howard
ResearchOpen Access08 Mar 2021
Communications Biology

Volume: 4, P: 1-11
High-rate intercity quantum key distribution with a semiconductor single-photon source

High-rate intercity quantum key distribution using a single-photon source with a quantum dot embedded in a circular Bragg grating photonic structure.

Jingzhong Yang
Zenghui Jiang
Fei Ding
ResearchOpen Access02 Jul 2024
Light: Science & Applications

Volume: 13, P: 1-10
Preparedness as a key factor for human biomonitoring programs after chemical incidents

Michael Bader
Sandra Bäcker
Tom Van Weyenbergh
Research27 Mar 2021
Journal of Exposure Science & Environmental Epidemiology

Volume: 31, P: 867-875
Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

Forcato et al. show that incomplete reminder cues rather than complete ones stabilize human memories during sleep. This study suggests that only incomplete reminders initiate long-term memory stabilization via mismatch detection during sleep.

Cecilia Forcato
Jens G. Klinzing
Susanne Diekelmann
ResearchOpen Access04 Dec 2020
Communications Biology

Volume: 3, P: 1-13
Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats

Agata Casado-Sainz
Frederik Gudmundsen
Mikael Palner
Research01 Nov 2021
Neuropsychopharmacology

Volume: 47, P: 454-464
Neuroplasticity and functional recovery in multiple sclerosis

Despite widespread damage associated with multiple sclerosis (MS) pathology, recovery of function can occur, driven by adaptive plasticity in brain networks. Tomassini et al. review the mechanisms underlying functional recovery in MS, and discuss interventions that might promote this process. Methodological considerations for imaging neuroplasticity using functional MRI are also highlighted.

Valentina Tomassini
Paul M. Matthews
Jacqueline Palace
Reviews18 Sept 2012
Nature Reviews Neurology

Volume: 8, P: 635-646
Characterization of white blood cell ratios in South American camelids presented at a veterinary teaching hospital

Matthias Gerhard Wagener
Max Kornblum
Frederik Kiene
ResearchOpen Access29 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Differentiated thyroid cancer—personalized therapies to prevent overtreatment

The management of differentiated thyroid cancer (DTC) is undergoing a paradigm shift, with the recognition that personalized therapies might lead to improved outcomes with reduced severity and frequency of complications. In this Review, Markus Luster and colleagues discuss aspects of DTC management that are suitable for individualization, including the extent of surgery, the dosage of¹³¹I and the use of levothyroxine. Advances in imaging techniques and the potential benefit of multitargeted kinase inhibitors are also discussed in the context of DTC management.

Markus Luster
Theresia Weber
Frederik A. Verburg
Reviews01 Jul 2014
Nature Reviews Endocrinology

Volume: 10, P: 563-574
Synthesis of aprotic ionic liquids

Ionic liquids (ILs) can be formed from a combination of anions and cations, each with very distinct properties. However, there is no standard methodology for their synthesis. In this Primer, Koutsoukos et al. outline the considerations, advantages and disadvantages of various synthetic routes for ILs.

Spyridon Koutsoukos
Julian Becker
Tom Welton
Reviews30 Jun 2022
Nature Reviews Methods Primers

Volume: 2, P: 1-18
A metalens-based analog computing system for ultrasonic Fourier transform calculations

Robert Frederik Uy
Viet Phuong Bui
ResearchOpen Access12 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury

Shubhayu Bhattacharyay
Florian D. van Leeuwen
Tommaso Zoerle
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-18

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