In the Saccharomyces cerevisiae pheromone response pathway, the MAP kinase Fus3 mediates the rapid negative feedback that adjusts the dose–response of the downstream system response to match that of receptor-ligand binding. This 'dose–response alignment' improves the fidelity of information transmission. Negative feedback could be used as a general mechanism in signalling systems to align dose–responses.
- Richard C. Yu
- C. Gustavo Pesce
- Roger Brent
