The fusion oncogene first discovered in patients with sarcomas,FUS, encodes a protein that pathologically accumulates in multiple neurodegenerative disorders. In this Review, Deng and colleagues discuss the involvement of various FUS mutations in amyotrophic lateral sclerosis, frontotemporal lobar degeneration and essential tremor, with particular emphasis on pathogenetic mechanisms. The authors argue that FUShas a general role in the neurodegenerative processes, and might therefore be a promising therapeutic target.
- Hao Deng
- Kai Gao
- Joseph Jankovic
