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Showing 201–250 of 250 results
Advanced filters: Author: Gemma Alderton Clear advanced filters

  • Why do some cancers only metastasize to certain organs? This question of organotropism is perplexing, and a team led by Lyden, Bromberg and Peinado have found that exosomes could be key.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 696-697

  • Genomic and transcriptomic analyses of Tasmanian devil facial tumour disease.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 79

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 613

    • Gemma Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 7, P: 226-227

  • Chiba and colleagues characterize the role of TIM3 in suppressing innate antitumour immune responses.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 584

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Drug Discovery
    Volume: 10, P: 732-733

  • Westbrook and colleagues show that knockdown of spliceosome components causes synthetic lethality in cells with hyperactive MYC, highlighting a possible therapeutic opportunity.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 575

  • Two papers report that mutations in calreticulin occur in most patients withJAK2−essential thrombocythemia and primary myelofibrosis, which are two common myeloproliferative neoplasms.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 75

    • Gemma Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 7, P: 403

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 162-163

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 5

  • Offermanns and colleagues found that tumour cell-activated platelets induce endothelial opening — which promotes extravasation — through adenine nucleotide-mediated activation of P2Y2 on endothelial cells.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 523

  • Röring and colleagues investigate the involvement of the dimer interface in the ability of RAF to mediate downstream signalling, with implications for targeting BRAF.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 374

  • A paper inCellshows that partial reprogramming of somatic cells induces epithelial tumorigenesis.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 217

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 754

    • Gemma Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 7, P: 405

  • A new role for retinoblastoma in regulating sister chromatid cohesion.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 541

  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282

  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141

  • Two papers examine the influence of different stem cell characteristics on tumorigenesis in an organ-specific and age-associated manner, continuing the debate on the influence of intrinsic and extrinsic factors on cancer risk.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 16, P: 753

  • Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

    • Dinesh Aggarwal
    • Andrew J. Page
    • Ewan M. Harrison
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

    • Dinesh Aggarwal
    • Ben Warne
    • Ian G. Goodfellow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • A paper inNatureidentifies glypican 1 as a marker of circulating exosomes derived from pancreatic ductal adenocarcinoma (and from some breast cancers) that could be an effective biomarker for early diagnosis and treatment monitoring.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 453

  • Two papers inSciencepresent evidence in mice that certain species of intestinal bacteria can drive antitumour immune responses and modulate responses to immune checkpoint blockade.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Immunology
    Volume: 16, P: 5

  • Three papers report the involvement of SLX4 in the Fanconi anaemia DNA repair pathway, and two papers show that mutations inSLX4cause a new subtype of Fanconi anaemia.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 11, P: 158-159

  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511

  • Three papers show that hepatocyte growth factor (HGF)–MET signalling is an important determinant of therapeutic responses and can be induced through paracrine, autocrine and endocrine production of HGF.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 505

  • Three papers report on the use of acetate as a nutrient in tumour cells undergoing metabolic stress.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 67

  • Two papers inSciencepresent evidence in mice that certain species of intestinal bacteria can drive antitumour immune responses and modulate responses to immune checkpoint blockade.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 16, P: 4

  • How similar are metastases to the primary tumour and other metastases in the same patient? And what does that tell us about the evolution of metastatic ability? Two papers investigated these questions in pancreatic ductal adenocarcinoma (PDAC).

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 17, P: 141

  • Two papers assess the role of glucose in lung cancer metabolismin vivo.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 16, P: 198

  • Three papers assess the mutational landscapes of human tumours, and all three find evidence for a role of APOBECs.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 681

  • An analysis by Tomasetti and Vogelstein prompted considerable debate about the origins of the genetic mutations that drive tumour initiation. Further fuel to this debate has recently been provided by an analysis from Wuet al.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 16, P: 68

  • Three papers now present different aspects of a similar story: altered splicing can lead to myelodysplastic syndrome (MDS) and even to progression to acute myeloid leukaemia (AML).

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 393

  • Two papers describe the evolution and heterogeneity of non-small-cell lung cancers by carrying out sequencing of samples from multiple tumour regions, with interesting conclusions and raising challenges for the future.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 763

  • Two papers show that KRAS-G12D-transformed pancreatic tumour cells produce GM-CSF, which recruits MDSCs to promote an immunosuppressive microenvironment.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 511

  • A paper inScienceby Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 17, P: 373

  • Several papers find that YAP1 has many important roles in tumorigenesis and tumour progression.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 6

  • Roger Lo and colleagues characterized the melanoma genome, transcriptome and epigenome to understand the landscape of acquired resistance to MAPK pathway inhibitors.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 635

  • Alterations to lipid metabolism pathways might underlie the pathogenesis of several diseases, including cancer.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 387

  • Two papers inCancer Cellreport the surprising findings that some components of the pancreatic cancer microenvironment suppress, rather than promote, tumour progression.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 449

  • KRAS-transformed pancreatic tumour cells produce GM-CSF, which recruits MDSCs to promote an immunosuppressive microenvironment.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Immunology
    Volume: 12, P: 555

  • Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+breast cancer are more likely to seed metastasis than those from established tumours.

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 17, P: 75

  • Three papers identify a new role for RB1 in regulating sister chromatid cohesion, which suppresses tumorigenesis by preventing chromosome instability

    • Gemma K. Alderton
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 536