The adipocyte-derived hormone leptin provides a link between metabolic status and the immune system, and has been implicated in the pathogenesis of autoimmune disorders such as multiple sclerosis (MS). Matarese et al. review clinical and molecular evidence for an association between leptin and MS disease activity, and consider the prospects for metabolic and nutritional interventions in the treatment of this condition.
- Giuseppe Matarese
- Pietro Biagio Carrieri
- Antonio La Cava
