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Acta Pharmacologica Sinica (13)
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Showing 1–50 of 52 results

Advanced filters: Author: Hai-Feng Chen Clear advanced filters

Optimal design and validation of antiviral siRNA for targeting hepatitis B virus

Jie Fu
Zhong-ming Tang
Xiao-hong Qian
Research01 Dec 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1522-1528
DynaRNA: accurate dynamic RNA conformation ensemble generation with diffusion model

DynaRNA, a diffusion-based generative model for RNA conformation ensemble, employs a denoising diffusion probabilistic model (DDPM) with equivariant graph neural network (EGNN) to directly model RNA 3D coordinates, enabling rapid exploration of RNA conformational space.

Zhengxin Li
Junjie Zhu
Hai-Feng Chen
ResearchOpen Access15 Oct 2025
Communications Biology

Volume: 8, P: 1-9
A hierarchically assembled 88-nuclei silver-thiacalix[4]arene nanocluster

The assembly of giant silver clusters by using macrocylic multidentate ligand remains a challenge. Here, the authors synthesize a chromate-templated 88-nuclei silver super calix and reveal the role of anion templating effects and a hierarchical assembly mechanism.

Zhi Wang
Hai-Feng Su
Lan-Sun Zheng
ResearchOpen Access16 Jan 2020
Nature Communications

Volume: 11, P: 1-8
Preclinical evaluation of the efficacy, pharmacokinetics and immunogenicity of JS-001, a programmed cell death protein-1 (PD-1) monoclonal antibody

Jie Fu
Fang Wang
Hai-feng Song
Research20 Mar 2017
Acta Pharmacologica Sinica

Volume: 38, P: 710-718
Cosmic-ray-induced correlated errors in superconducting qubit array

The correlated errors in superconducting qubits have been linked to high-energy particle impacts from cosmic rays, but a direct observation has been lacking. Here, the authors measure the quasiparticle bursts and correlated errors and separate the contributions of cosmic-ray muons and γ-rays in a 63-qubit processor.

Xuegang Li
Junhua Wang
Hai-Feng Yu
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-8
Author Correction: Full reconstruction of simplicial complexes from binary contagion and Ising data

Huan Wang
Chuang Ma
Hai-Feng Zhang
Amendments and CorrectionsOpen Access27 Jun 2022
Nature Communications

Volume: 13, P: 1
Twin-field quantum key distribution over a 511 km optical fibre linking two distant metropolitan areas

A field test of twin-field quantum key distribution was implemented through a 511 km optical fibre. To this end, precise wavelength control of remote independent laser sources and fast time- and phase-compensation systems are developed.

Jiu-Peng Chen
Chi Zhang
Jian-Wei Pan
Research21 Jun 2021
Nature Photonics

Volume: 15, P: 570-575
Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage

Shun-ying Hu
Hai-feng Duan
Hua Wang
Research14 Sept 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1415-1420
Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys

Su-qing Chen
Hai-feng Zhai
Lin Lu
Research01 Apr 2007
Acta Pharmacologica Sinica

Volume: 28, P: 473-483
Deciphering synergetic core-shell transformation from [Mo₆O₂₂@Ag₄₄] to [Mo₈O₂₈@Ag₅₀]

Understanding how one metal nanocluster transforms into another is of synthetic and fundamental importance. Here, the authors use mass spectrometry to reveal an acid-induced structural transformation between two Ag clusters that proceeds via a breakage-growth-reassembly mechanism.

Zhi Wang
Hai-Feng Su
Lan-Sun Zheng
ResearchOpen Access23 Oct 2018
Nature Communications

Volume: 9, P: 1-8
Identification of cross-linked peptides from complex samples

pLink, software for data analysis of cross-linked proteins coupled with mass spectrometry, estimates false discovery rate and enables analysis of protein complexes without extensive purification.

Bing Yang
Yan-Jie Wu
Meng-Qiu Dong
Research08 Jul 2012
Nature Methods

Volume: 9, P: 904-906
Free-space dissemination of time and frequency with 10⁻¹⁹ instability over 113 km

By using 1 W optical frequency combs and nanowatt-level linear optical sampling modules, a time–frequency dissemination over a free-space link of 113 km is achieved with a stability of less than 4 × 10⁻¹⁹ at 10,000 s.

Qi Shen
Jian-Yu Guan
Jian-Wei Pan
Research05 Oct 2022
Nature

Volume: 610, P: 661-666
Efflux of potassium ion is an important reason of HL-60 cells apoptosis induced by tachyplesin

Hai-tao Zhang
Jun Wu
Qi-feng Zhu
Research01 Oct 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1367-1374
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Xue-Jun Zhang
Wei Huang
Jian-Jun Liu
Research25 Jan 2009
Nature Genetics

Volume: 41, P: 205-210
CD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12⁺ microglia transformation

Pan-pan Gao
Hai-feng Jiang
Xiao-qian Chen
Research11 Jun 2025
Acta Pharmacologica Sinica

P: 1-18
Exploring dynamic interactions of single nanoparticles at interfaces for surface-confined electrochemical behavior and size measurement

Single-entity electrochemistry has been proposed for studying properties of single nanoparticles (NPs). Here, the authors make use of adsorption-mediated motion of Ag NPs to take individual NP size measurements using electrochemical impacts with excellent agreement to standard imaging techniques.

Hui Ma
Jian-Fu Chen
Yi-Tao Long
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-9
Development and Validation of a Nomogram for Predicting Survival in Patients with Advanced Pancreatic Ductal Adenocarcinoma

Qing-Long Deng
Shu Dong
Qi-Wen Chen
ResearchOpen Access14 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study

Le-Ting Zhou
Yu-Han Cao
Bi-Cheng Liu
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Full reconstruction of simplicial complexes from binary contagion and Ising data

Data-driven recovery of topology is challenging for networks beyond pairwise interactions. The authors propose a framework to reconstruct complex networks with higher-order interactions from time series, focusing on networks with 2-simplexes where social contagion and Ising dynamics generate binary data.

Huan Wang
Chuang Ma
Hai-Feng Zhang
ResearchOpen Access01 Jun 2022
Nature Communications

Volume: 13, P: 1-10
LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity

Shao-Hua Wang
Xiao-Lin Zhu
Yang-Xin Chen
ResearchOpen Access28 May 2021
Cell Death & Disease

Volume: 12, P: 1-16
Design and fabrication of far ultraviolet filters based on π-multilayer technology in high-k materials

Xiao-Dong Wang
Bo Chen
Yun-Peng Li
ResearchOpen Access17 Feb 2015
Scientific Reports

Volume: 5, P: 1-6
Trapping an octahedral Ag₆ kernel in a seven-fold symmetric Ag₅₆ nanowheel

High-nuclearity silver clusters are appealing synthetic targets for their remarkable structures, but most are isolated serendipitously. Here, the authors describe the rational use of solvents to form cluster-in-cluster silver nanowheels, which comprise an octahedral Ag₆⁴⁺ core surrounded by a Ag₅₆ cage of unusual seven-fold symmetry.

Zhi Wang
Hai-Feng Su
Lan-Sun Zheng
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-8
Identifying the key obstacle in photocatalytic oxygen evolution on rutile TiO₂

A high reaction barrier is often assumed as the limiting factor in photocatalytic oxygen evolution reactions on titanium dioxide. Now, it is shown that the hole concentration at the semiconductor’s surface is the actual bottleneck in determining the catalytic efficiency.

Dong Wang
Tian Sheng
P. Hu
Research16 Apr 2018
Nature Catalysis

Volume: 1, P: 291-299
Immunostimulatory and anti-neoplasm effects of a novel palindrome CpG oligodeoxynucleotide in mice

Hai-yan Du
Li-hou Dong
Hai-feng Song
Research25 Jun 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1047-1054
Acyl-CoA thioesterase 8 induces gemcitabine resistance via regulation of lipid metabolism and antiferroptotic activity in pancreatic ductal adenocarcinoma

Bo-rui Li
Ting Wang
Xiao-wu Xu
ResearchOpen Access12 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1742-1756
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer

Hai-di Chen
Zeng Ye
Yi Qin
Research06 Dec 2023
Acta Pharmacologica Sinica

Volume: 45, P: 844-856
Gefitinib (an EGFR tyrosine kinase inhibitor) plus anlotinib (an multikinase inhibitor) for untreated, EGFR-mutated, advanced non-small cell lung cancer (FL-ALTER): a multicenter phase III trial

Hua-Qiang Zhou
Ya-Xiong Zhang
Wen-Feng Fang
ResearchOpen Access13 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-12
Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion

Jie Yu
Hai-feng Zhang
Feng Gao
Research01 Jul 2006
Acta Pharmacologica Sinica

Volume: 27, P: 919-926
Solar X-ray and EUV imager on board the FY-3E satellite

Bo Chen
Xiao-Xin Zhang
Zhong-Dong Yang
ResearchOpen Access22 Nov 2022
Light: Science & Applications

Volume: 11, P: 1-13
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

Dai Zhang and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify a new susceptibility locus at 11p11.2 and also identify a locus at 6p21-22.1 in the extended MHC region, which has previously been reported to be associated with schizophrenia in individuals of European descent.

Wei-Hua Yue
Hai-Feng Wang
Dai Zhang
Research30 Oct 2011
Nature Genetics

Volume: 43, P: 1228-1231
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

Shuang-Xi Ren
Gang Fu
Guo-Ping Zhao
ResearchOpen Access24 Apr 2003
Nature

Volume: 422, P: 888-893
A genome-wide association study identifies two new risk loci for Graves' disease

Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27.

Xun Chu
Chun-Ming Pan
Huai-Dong Song
Research14 Aug 2011
Nature Genetics

Volume: 43, P: 897-901
Remnant cholesterol and risk of incident hypertension: a population-based prospective cohort study

Da-Chuan Guo
Jing-Wei Gao
Hai-Feng Zhang
Research11 Jan 2024
Hypertension Research

Volume: 47, P: 1157-1166
Wide-field auroral imager onboard the Fengyun satellite

Xiao-Xin Zhang
Bo Chen
Jin-Song Wang
ResearchOpen Access22 May 2019
Light: Science & Applications

Volume: 8, P: 1-12
Prediction of skin disease using a new cytological taxonomy based on cytology and pathology with deep residual learning method

Jin Bu
Yu Lin
Er-Xia Shen
ResearchOpen Access02 Jul 2021
Scientific Reports

Volume: 11, P: 1-9
¹²⁴I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies

Xiao-kun Ma
Te-li Liu
Zhi Yang
Research25 Sept 2023
Acta Pharmacologica Sinica

Volume: 45, P: 436-448
Extreme events in multilayer, interdependent complex networks and control

Yu-Zhong Chen
Zi-Gang Huang
Ying-Cheng Lai
ResearchOpen Access27 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

Siwen Niu
Ning Wang
Xian-Wen Yang
Research04 Apr 2018
The Journal of Antibiotics

Volume: 71, P: 658-661
Auxin regulates anthocyanin biosynthesis through the Aux/IAA–ARF signaling pathway in apple

Yi-cheng Wang
Nan Wang
Xue-sen Chen
ResearchOpen Access01 Dec 2018
Horticulture Research

Volume: 5, P: 1-11
GmSYP24, a putative syntaxin gene, confers osmotic/drought, salt stress tolerances and ABA signal pathway

Li-Miao Chen
Yi-Sheng Fang
Xin-An Zhou
ResearchOpen Access12 Apr 2019
Scientific Reports

Volume: 9, P: 1-12
Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling

Hong-jin Wang
Hai-feng Ran
Xiao-yu Xu
Research18 Nov 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1670-1685
Turning Indium Oxide into a Superior Electrocatalyst: Deterministic Heteroatoms

Bo Zhang
Nan Nan Zhang
Hua Gui Yang
ResearchOpen Access31 Oct 2013
Scientific Reports

Volume: 3, P: 1-7
SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury

Lin-Li Lv
Cui Wang
Bi-Cheng Liu
ResearchOpen Access23 Sept 2021
Cell Death & Disease

Volume: 12, P: 1-11
IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation

Hai-Feng Zhang
Mao-Xiong Wu
Jing-Feng Wang
ResearchOpen Access03 Nov 2017
Experimental & Molecular Medicine

Volume: 49, P: e388
Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Lin-Li Lv
Ye Feng
Bi-Cheng Liu
Research16 May 2019
Cell Death & Differentiation

Volume: 27, P: 210-226
Kondo scenario of the γ–α phase transition in single crystalline cerium thin films

Xie-Gang Zhu
Yu Liu
Xin-Chun Lai
ResearchOpen Access10 Jul 2020
npj Quantum Materials

Volume: 5, P: 1-9
Synergistic Modification Induced Specific Recognition between Histone and TRIM24 via Fluctuation Correlation Network Analysis

Jinmai Zhang
Huajie Luo
Hai-Feng Chen
ResearchOpen Access15 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode

Tianle Qian
Jing Wo
Hai-Feng Chen
ResearchOpen Access11 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Dynamics Correlation Network for Allosteric Switching of PreQ₁ Riboswitch

Wei Wang
Cheng Jiang
Hai-Feng Chen
ResearchOpen Access03 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
Association of long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus

Jun Li
Guo-Cui Wu
Dong-Qing Ye
ResearchOpen Access09 Nov 2017
Scientific Reports

Volume: 7, P: 1-8

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