Nature Search

p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2⁺ breast cancer that limits trastuzumab deruxtecan efficacy

Hu et al. discovered that the truncated form of human epidermal growth factor receptor 2 (HER2), called p95HER2, drives tumor progression and resistance to the antibody–drug conjugate trastuzumab deruxtecan in HER2⁺ breast cancer. Blocking p95HER2 restores antitumor immunity.

Dong Hu
Xiaoshuang Lyu
Peter C. Lucas
Research27 Jun 2025
Nature Cancer

Volume: 6, P: 1202-1222
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape

The functions of small nucleolar RNAs (snoRNAs) in cancer remain to be studied. Here the authors show that the snoRNA Snord67 promotes lymph node metastasis of breast cancer cells through guiding modifications of the spliceosome and regulating the splicing landscape.

Yvonne L. Chao
Katherine I. Zhou
Chad V. Pecot
ResearchOpen Access02 May 2025
Nature Communications

Volume: 16, P: 1-23
Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages

Transcriptional analysis of lipid associated macrophages across chronic inflammatory diseases and tissues reveals shared and tissue-restricted gene expression programs.

Yingzheng Xu
Hannah Hillman
Jesse W. Williams
ResearchOpen Access23 Jun 2025
Communications Biology

Volume: 8, P: 1-13
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
The GPCR–Gα_s–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

Here, the authors use computational screening and a chemogenetic analysis of transgenic mice to show that Gα_s-coupled G-protein-coupled receptors on exhausted CD8⁺ T cells are involved in suppression of effector functions and inhibition of the protective effects of immune checkpoint immunotherapy.

Victoria H. Wu
Bryan S. Yung
J. Silvio Gutkind
Research12 Jun 2023
Nature Immunology

Volume: 24, P: 1318-1330
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis

Patterson, Firulyova, et al. report that TREM2 is a key regulator of foamy macrophage differentiation. Myeloid-specific deletion of Trem2 caused increased macrophage susceptibility to cholesterol-mediated toxicity and cell death and significantly attenuated atherosclerotic plaque progression in mice.

Michael T. Patterson
Maria M. Firulyova
Jesse W. Williams
ResearchOpen Access30 Oct 2023
Nature Cardiovascular Research

Volume: 2, P: 1015-1031
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Circular extrachromosomal DNA in high-risk medulloblastoma contributes to tumor heterogeneity and associates with relapse and survival. Enhancer rewiring events involving known oncogenes are frequent events, affecting transcription and proliferation.

Owen S. Chapman
Jens Luebeck
Lukas Chavez
ResearchOpen Access09 Nov 2023
Nature Genetics

Volume: 55, P: 2189-2199
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

Zinc is an essential cofactor for bacterial metabolism. Here, the authors show that the probiotic bacterium Escherichia coli Nissle 1917 utilizes the siderophore yersiniabactin as a zincophore, allowing the microbe to grow in zinc-limited media and to thrive in the inflamed gut.

Judith Behnsen
Hui Zhi
Manuela Raffatellu
ResearchOpen Access01 Dec 2021
Nature Communications

Volume: 12, P: 1-15
Identification of type 2 diabetes loci in 433,540 East Asian individuals

A meta-analysis of genome-wide association study data from 77,418 individuals of East Asian ancestry with type 2 diabetes identifies novel variants associated with increased risk of type 2 diabetes.

Cassandra N. Spracklen
Momoko Horikoshi
Xueling Sim
Research06 May 2020
Nature

Volume: 582, P: 240-245
KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

Adult-type granulosa cell tumors of the ovary (aGCTs) are rare and recurrence is difficult to treat. Here, the authors observe in aGCT a novel recurrent somatic truncating mutation of KMT2D, more frequent in recurrent aGCT, and also non-genetic loss of KMT2D expression.

R. Tyler Hillman
Joseph Celestino
P. Andrew Futreal
ResearchOpen Access27 Jun 2018
Nature Communications

Volume: 9, P: 1-7
The relationships between prolonged sedentary time, physical activity, cognitive control, and P3 in adults with overweight and obesity

Dominika M. Pindus
Caitlyn G. Edwards
Naiman A. Khan
Research01 Feb 2021
International Journal of Obesity

Volume: 45, P: 746-757
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.

Patty J. Lee
Christopher C. Benz
Mingyu Yang
Reviews20 Dec 2022
Nature Aging

Volume: 2, P: 1090-1100
Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations

Higinio Dopeso
Andrea M. Gazzo
Jorge S. Reis-Filho
ResearchOpen Access12 Feb 2024
npj Precision Oncology

Volume: 8, P: 1-11
Oral cancer induced TRPV1 sensitization is mediated by PAR₂ signaling in primary afferent neurons innervating the cancer microenvironment

Nicole N. Scheff
Ian M. Wall
Brian L. Schmidt
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

Roberta S. dos Reis
Shilpa Sant
Velpandi Ayyavoo
ResearchOpen Access16 Sept 2020
Scientific Reports

Volume: 10, P: 1-17
Rare subtypes of triple negative breast cancer: Current understanding and future directions

Alexandra Thomas
Jorge S. Reis-Filho
Hannah Y. Wen
ReviewsOpen Access23 Jun 2023
npj Breast Cancer

Volume: 9, P: 1-9

Search

p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2⁺ breast cancer that limits trastuzumab deruxtecan efficacy

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A saturated map of common genetic variants associated with human height

The GPCR–Gα_s–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis

Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

Identification of type 2 diabetes loci in 433,540 East Asian individuals

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

The relationships between prolonged sedentary time, physical activity, cognitive control, and P3 in adults with overweight and obesity

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations

Oral cancer induced TRPV1 sensitization is mediated by PAR₂ signaling in primary afferent neurons innervating the cancer microenvironment

Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

Rare subtypes of triple negative breast cancer: Current understanding and future directions

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