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Showing 101–148 of 148 results

Advanced filters: Author: Heather N. Allen Clear advanced filters

Genetic evidence of assortative mating in humans

Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

Matthew R. Robinson
Aaron Kleinman
Peter M. Visscher
Research09 Jan 2017
Nature Human Behaviour

Volume: 1, P: 1-13
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1788
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1791
Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without affecting opiate analgesia.

Nicole E Burma
Robert P Bonin
Tuan Trang
Research30 Jan 2017
Nature Medicine

Volume: 23, P: 355-360
Viral genomic features predict Orthopoxvirus reservoir hosts

A study leverages host ecological traits and viral genomic features to predict potential hosts of orthopoxviruses using a machine learning approach, revealing critical hotspots for orthopoxvirus emergence.

Katie K. Tseng
Heather Koehler
Stephanie N. Seifert
ResearchOpen Access26 Feb 2025
Communications Biology

Volume: 8, P: 1-12
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Call of the wild: antibiotic resistance genes in natural environments

Antibiotic resistance seriously threatens our ability to treat infectious diseases. The genes conferring resistance can easily move between organisms, resulting in nearly untreatable diseases. Jo Handelsman and colleagues describe how resistance is spread, the origin of the genes conferring this resistance and the roles they may have in their natural environments.

Heather K. Allen
Justin Donato
Jo Handelsman
Reviews01 Mar 2010
Nature Reviews Microbiology

Volume: 8, P: 251-259
Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

Miruna C. Barbu
Athina Spiliopoulou
Heather C. Whalley
ResearchOpen Access04 Feb 2020
Translational Psychiatry

Volume: 10, P: 1-12
Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
Amendments and CorrectionsOpen Access08 Jan 2025
Nature

Volume: 637, P: E26
A finite element model for predicting impact-induced damage to a skin simulant

Syed A. Imam
Angus C. Hughes
Tom Allen
ResearchOpen Access04 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
De novo mutations in epileptic encephalopathies

Exome sequencing has found an excess of de novo mutations in the ∼4,000 most intolerant genes in patients with two classical epileptic encephalopathies (infantile spasms and Lennox–Gastaut syndrome); among them are multiple de novo mutations in GABRB3 and ALG13.

Andrew S. Allen
Samuel F. Berkovic
Melodie R. Winawer
Research11 Aug 2013
Nature

Volume: 501, P: 217-221
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

In prostate cancer, the oncogenicity of transcription factor ERG is mediated, in part, by competition with another member of the ETS family, ERF.

Rohit Bose
Wouter R. Karthaus
Charles L. Sawyers
Research14 Jun 2017
Nature

Volume: 546, P: 671-675
Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome

Adam Phillippy, Curtis Van Tassell, Timothy Smith and colleagues present a new reference genome assembly for the domestic goat using a pipeline that improves contiguity of the assembly by more than 250-fold. The pipeline uses a combination of short- and long-read sequencing, optical mapping, and chromatin interaction mapping.

Derek M Bickhart
Benjamin D Rosen
Timothy P L Smith
ResearchOpen Access06 Mar 2017
Nature Genetics

Volume: 49, P: 643-650
Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy

Nicholas D. Henkel
Marissa A. Smail
Rammohan Shukla
ResearchOpen Access27 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
Toddler’s behavior and its impacts on exposure to polybrominated diphenyl ethers

Kate Hoffman
Thomas F Webster
Heather M Stapleton
Research09 Mar 2016
Journal of Exposure Science & Environmental Epidemiology

Volume: 27, P: 193-197
Prognostic impact of corticosteroid and tocilizumab use following chimeric antigen receptor T-cell therapy for multiple myeloma

Bruno Almeida Costa
Jessica Flynn
Sham Mailankody
ResearchOpen Access27 May 2024
Blood Cancer Journal

Volume: 14, P: 1-8
Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2^−/− mice and human primary sclerosing cholangitis

The bile acid rsodeoxycholic acid (UDCA) is the choice of treatment for primary biliary cholangitis patients with abnormal liver enzymes; however, its mechanism is not clear, and is the focus of this investigation. Bile acids alter mast cell (MC) histamine release. Following liver injury, such as that seen in primary sclerosing cholangitis, MCs infiltrate the liver. MC-derived histamine increases biliary damage, fibrosis, and inflammation. UDCA treatment decreases these parameters via reduced MC activation.

Fanyin Meng
Lindsey Kennedy
Heather Francis
Research24 Aug 2018
Laboratory Investigation

Volume: 98, P: 1465-1477
Alterations in adaptive immunity persist during long-duration spaceflight

Brian Crucian
Raymond P Stowe
Clarence Sams
ResearchOpen Access03 Sept 2015
npj Microgravity

Volume: 1, P: 1-10
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Refining the risk for fragile X–associated primary ovarian insufficiency (FXPOI) by FMR1 CGG repeat size

Emily Graves Allen
Krista Charen
Stephanie L. Sherman
ResearchOpen Access29 Apr 2021
Genetics in Medicine

Volume: 23, P: 1648-1655
STING dependent BAX-IRF3 signaling results in apoptosis during late-stage Coxiella burnetii infection

Manish Chauhan
Chelsea A. Osbron
Alan G. Goodman
ResearchOpen Access08 Mar 2024
Cell Death & Disease

Volume: 15, P: 1-17
Clustering of comorbid conditions among women who carry an FMR1 premutation

Emily Graves Allen
Krista Charen
Stephanie L. Sherman
ResearchOpen Access03 Jan 2020
Genetics in Medicine

Volume: 22, P: 758-766
Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress

Alexandra B. Moussa-Tooks
Eric R. Larson
William P. Hetrick
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-14
Change, predictors and correlates of weight- and health-related quality of life in adolescents 2-years following bariatric surgery

Jennifer Reiter-Purtill
Sanita Ley
Meg H. Zeller
Research17 Jun 2019
International Journal of Obesity

Volume: 44, P: 1467-1478
Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death

Caroline S. Hirst
Lincon A. Stamp
Heather M. Young
ResearchOpen Access30 Nov 2017
Scientific Reports

Volume: 7, P: 1-14
Postnatal intervention for the treatment of FNAIT: a systematic review

Jillian M. Baker
Nadine Shehata
Erica Wood
Reviews10 Apr 2019
Journal of Perinatology

Volume: 39, P: 1329-1339
Multiple mechanisms drive phage infection efficiency in nearly identical hosts

Cristina Howard-Varona
Katherine R. Hargreaves
Matthew B. Sullivan
Research22 Mar 2018
The ISME Journal

Volume: 12, P: 1605-1618
Diversity of Antibiotic Resistance genes and Transfer Elements-Quantitative Monitoring (DARTE-QM): a method for detection of antimicrobial resistance in environmental samples

Smith et al. present DARTE-QM, a highthroughput sequencing method for screening environmental DNA samples for antibiotic resistance genes on a broad scale. This method is demonstrated as effective on soil, manure and livestock fecal samples, as well as a synthetic mock-community reference.

Schuyler D. Smith
Jinlyung Choi
Adina Howe
ResearchOpen Access17 Mar 2022
Communications Biology

Volume: 5, P: 1-9
Maintenance and Representation of Mind Wandering during Resting-State fMRI

Ying-hui Chou
Mark Sundman
Nan-kuei Chen
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Effect of Variation in Diacylglycerol Kinase Eta (DGKH) Gene on Brain Function in a Cohort at Familial Risk of Bipolar Disorder

Heather C Whalley
Martina Papmeyer
Andrew M McIntosh
Research02 Nov 2011
Neuropsychopharmacology

Volume: 37, P: 919-928
Never judge a book by its cover: how NICU evaluators reach conclusions about quality of care

Ravi Dhurjati
Nabeel Wahid
Jochen Profit
Research28 Mar 2018
Journal of Perinatology

Volume: 38, P: 751-758
Shared Molecular Signatures Across Neurodegenerative Diseases and Herpes Virus Infections Highlights Potential Mechanisms for Maladaptive Innate Immune Responses

Ana Caroline Costa Sa
Heather Madsen
James R. Brown
ResearchOpen Access19 Jun 2019
Scientific Reports

Volume: 9, P: 1-16
Ethanol Reduces Neuronal Excitability of Lateral Orbitofrontal Cortex Neurons Via a Glycine Receptor Dependent Mechanism

Kimberly A Badanich
Patrick J Mulholland
John J Woodward
Research11 Jan 2013
Neuropsychopharmacology

Volume: 38, P: 1176-1188
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Associated systemic and ocular disorders in patients with congenital unilateral cataracts: the Infant Aphakia Treatment Study experience

E I Traboulsi
D Vanderveen
Ken Cheng
Research17 Jun 2016
Eye

Volume: 30, P: 1170-1174
A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Lutnick et al. develop a cloud-based deep learning tool for whole slide image segmentation. The authors provide several examples of its application in renal pathology, for segmenting glomeruli, interstitial fibrosis and other features of interest.

Brendon Lutnick
David Manthey
Angela Victoria-Castro
ResearchOpen Access19 Aug 2022
Communications Medicine

Volume: 2, P: 1-15
Angiopoietin-1 protects against endotoxin-induced neonatal lung injury and alveolar simplification in mice

Umar Salimi
Heather L. Menden
Venkatesh Sampath
Research12 May 2021
Pediatric Research

Volume: 91, P: 1405-1415
mGluR8 Modulates Excitatory Transmission in the Bed Nucleus of the Stria Terminalis in a Stress-Dependent Manner

Heather B Gosnell
Yuval Silberman
Danny G Winder
Research30 Mar 2011
Neuropsychopharmacology

Volume: 36, P: 1599-1607
Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data

Andrew S Allen
Samuel F Berkovic
Melodie R Winawer
Research17 May 2017
European Journal of Human Genetics

Volume: 25, P: 894-899
G2A is an oncogenic G protein-coupled receptor

Irene E Zohn
Mark Klinger
Robert J Kay
Research08 Aug 2000
Oncogene

Volume: 19, P: 3866-3877
Associations between serum levels of polybrominated diphenyl ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women

Danielle E Buttke
Amy Wolkin
Marie Lynn Miranda
Research04 Jul 2012
Journal of Exposure Science & Environmental Epidemiology

Volume: 23, P: 176-182
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Zuzana Kos
Elvire Roblin
Zsuzsanna Bago-Horvath
ResearchOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-16
The spino-parabrachio-amygdaloid pathway is critical for the manifestation of chronic pain

Tyler S. Nelson
Heather N. Allen
Research Highlights22 Sept 2023
Neuropsychopharmacology

Volume: 49, P: 491-492
Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil

Heather K Allen
Luke A Moe
Jo Handelsman
Research09 Oct 2008
The ISME Journal

Volume: 3, P: 243-251
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jan Hudeček
Leonie Voorwerk
Zsuzsanna Bago-Horvath
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-8
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Mohamed Amgad
Elisabeth Specht Stovgaard
Zaheed Husain
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-13

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