TRF2 is a member of the telosome/shelterin complex, which helps maintain telomere integrity. Using an oriented peptide library based on a previously identified TRF2-interaction region to define a consensus sequence for binding, new proteins have been identified as TRF2 interactors and implicated in telomeric functions. This suggests that TRF2 acts as a hub for recruiting different proteins to the telomere via a distinct linear sequence.
- Hyeung Kim
- Ok-Hee Lee
- Zhou Songyang
