Nature Search

Analysis of 14-3-3σ expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma

Dimitri Lodygin
Amir S Yazdi
Heiko Hermeking
Research21 Aug 2003
Oncogene

Volume: 22, P: 5519-5524
Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc

Snehalata A Pawar
Marilyn N Szentirmay
Michèle Sawadogo
Research21 Jun 2004
Oncogene

Volume: 23, P: 6125-6135
Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

The c-MYC oncoprotein has many targets whose actions are not fully understood including TFAP4/AP4. Here, the authors show in a mouse model of inherited colorectal cancer that deletion of AP4 decreased the frequency of c-MYC-driven intestinal adenomas, and reveal Ap4 as a mediator of adenoma initiation and regulator of colonic and intestinal stem cell and Paneth cell homeostasis.

Stephanie Jaeckel
Markus Kaller
Heiko Hermeking
ResearchOpen Access03 Sept 2018
Nature Communications

Volume: 9, P: 1-17
Prostate cancer is characterized by epigenetic silencing of 14-3-3σ expression

Dimitri Lodygin
Joachim Diebold
Heiko Hermeking
Research18 Oct 2004
Oncogene

Volume: 23, P: 9034-9041
MicroRNA-34a regulates cardiac ageing and function

A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.

Reinier A. Boon
Kazuma Iekushi
Stefanie Dimmeler
Research20 Feb 2013
Nature

Volume: 495, P: 107-110
Author Correction: 14-3-3σ is required to prevent mitotic catastrophe after DNA damage

Timothy A. Chan
Heiko Hermeking
Bert Vogelstein
Amendments and Corrections22 Aug 2023
Nature

Volume: 621, P: E28-E29
MicroRNAs in the p53 network: micromanagement of tumour suppression

This Review discusses how microRNAs (miRNAs) are intricately involved in p53 signalling, from the regulation of p53 expression and activity to contributing to various tumour suppressor effector functions of p53. Evidence for the importance of these miRNAs from cancer-specific alterations, and the implications for diagnostics and therapeutics, are also considered.

Heiko Hermeking
Reviews17 Aug 2012
Nature Reviews Cancer

Volume: 12, P: 613-626
14-3-3σ is required to prevent mitotic catastrophe after DNA damage

Timothy A. Chan
Heiko Hermeking
Bert Vogelstein
Research07 Oct 1999
Nature

Volume: 401, P: 616-620
The 14-3-3 cancer connection

Heiko Hermeking
Reviews01 Dec 2003
Nature Reviews Cancer

Volume: 3, P: 931-943
The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

Anne BENZINGER
Grzegorz M POPOWICZ
Heiko HERMEKING
Research01 Apr 2005
Cell Research

Volume: 15, P: 219-227
Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression

Matjaz Rokavec
Markus Kaller
Heiko Hermeking
ResearchOpen Access05 Jul 2017
Scientific Reports

Volume: 7, P: 1-15
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Colibactin-producing pks+ Escherichia coli are frequent constituents of the human intestinal microbiota. Here, the authors show that short exposure of cells to pks+ E. coli induces chromosomal aberrations, genomic instability, and multiple features of transformation reminiscent of colorectal cancer.

Amina Iftekhar
Hilmar Berger
Thomas F. Meyer
ResearchOpen Access12 Feb 2021
Nature Communications

Volume: 12, P: 1-15
Mir34a constrains pancreatic carcinogenesis

Ana Hidalgo-Sastre
Clara Lubeseder-Martellato
Guido von Figura
ResearchOpen Access15 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
The miR-34 family in cancer and apoptosis

H Hermeking
Reviews22 May 2009
Cell Death & Differentiation

Volume: 17, P: 193-199
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer

The clonal architecture of colon cancer and the relevance of tumor cell subpopulations for clonal outgrowth are poorly understood. Here, the authors describe the clonal architecture and dynamics in human colon cancer by using a multicolor lineage tracing approach in colon cancer xenografts.

Sebastian Lamprecht
Eva Marina Schmidt
David Horst
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-9
Myeloid Mir34a suppresses colitis-associated colon cancer: characterization of mediators by single-cell RNA sequencing

Janine König
Matjaz Rokavec
Heiko Hermeking
ResearchOpen Access18 Oct 2024
Cell Death & Differentiation

Volume: 32, P: 225-241
AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation

R Jackstadt
P Jung
H Hermeking
ResearchOpen Access15 Aug 2013
Cell Death & Disease

Volume: 4, P: e775
Analysis of human transcriptomes

Victor E Velculescu
Stephen L Madden
Kenneth W Kinzler
Correspondence01 Dec 1999
Nature Genetics

Volume: 23, P: 387-388
What is left in the 'post-genome' era?

Heiko Hermeking
Books & Arts01 Dec 2001
Nature Cell Biology

Volume: 3, P: E276
Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis

Chunfeng Liu
Matjaz Rokavec
Heiko Hermeking
ResearchOpen Access28 Oct 2023
Cell Death & Disease

Volume: 14, P: 1-15
Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis

Chunfeng Liu
Matjaz Rokavec
Heiko Hermeking
ResearchOpen Access20 May 2023
Cell Death & Differentiation

Volume: 30, P: 1771-1785
CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34

Zekai Huang
Markus Kaller
Heiko Hermeking
ResearchOpen Access24 Jul 2023
Cell Death & Differentiation

Volume: 30, P: 2017-2034
Human Proteinpedia enables sharing of human protein data

Suresh Mathivanan
Mukhtar Ahmed
Akhilesh Pandey
Correspondence01 Feb 2008
Nature Biotechnology

Volume: 26, P: 164-167
Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

Paulette Mhawech
Ana Benz
Juerg Schwaller
Research16 Jul 2004
Modern Pathology

Volume: 18, P: 340-348
In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance

Anna-Katharina Wirth
Lucas Wange
Irmela Jeremias
ResearchOpen Access04 Nov 2022
Leukemia

Volume: 36, P: 2863-2874
The role of epigenetic inactivation of 14-3-3σ in human cancer

Dmitri LODYGIN
Heiko HERMEKING
Reviews01 Apr 2005
Cell Research

Volume: 15, P: 237-246

Search

Analysis of 14-3-3σ expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma

Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

Prostate cancer is characterized by epigenetic silencing of 14-3-3σ expression

MicroRNA-34a regulates cardiac ageing and function

Author Correction: 14-3-3σ is required to prevent mitotic catastrophe after DNA damage

MicroRNAs in the p53 network: micromanagement of tumour suppression

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

The 14-3-3 cancer connection

The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Mir34a constrains pancreatic carcinogenesis

The miR-34 family in cancer and apoptosis

Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer

Myeloid Mir34a suppresses colitis-associated colon cancer: characterization of mediators by single-cell RNA sequencing

AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation

Analysis of human transcriptomes

What is left in the 'post-genome' era?

Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis

Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis

CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34

Human Proteinpedia enables sharing of human protein data

Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance

The role of epigenetic inactivation of 14-3-3σ in human cancer

Search

Quick links

Search

Filter By:

Search

Quick links